Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Zubieta, J.-K. Articles by Domino, E. F. Search for Related Content PubMed Citation Articles by Zubieta, J.-K. Articles by Domino, E. F. Nicotine Neurophysiology PET Related Article

Regional Cerebral Blood Flow Responses to Smoking in Tobacco Smokers After Overnight Abstinence

OBJECTIVE: The purpose of the study was to determine the effects of cigarette smoking on brain regional function in a group of chronic smokers by using cerebral blood flow (CBF) measures and positron emission tomography (PET). METHOD: Nineteen tobacco smokers were studied after about 12 hours of smoking abstinence. Regional CBF (rCBF) measures were obtained with PET and [¹⁵O]H₂O in six consecutive scans. Two average-nicotine-yield (1.0 mg) and one denicotinized (0.08 mg) research cigarettes with similar tar yields (9.5 mg and 9.1 mg, respectively) were smoked in a double-blind design, preceded and followed by baseline scans. The rCBF effects of smoking were compared to baseline measures and between cigarettes, as well as to subjective ratings of craving for cigarettes. RESULTS: Smoking the first cigarette of the day resulted in increases in rCBF in the visual cortex and the cerebellum and reductions in the anterior cingulate, the right hippocampus, and the ventral striatum, including the nucleus accumbens. Cigarette craving scores correlated with rCBF changes in the dorsal anterior cingulate and right hippocampus. Less pronounced effects were observed with the second cigarette and the denicotinized cigarette. CONCLUSIONS: Smoking affects rCBF not only in areas of the brain rich in nicotinic cholinergic receptors but also in areas implicated in the rewarding effects of drugs of abuse. Furthermore, craving for a cigarette in chronic smokers was correlated with rCBF in the right hippocampus, an area involved in associating environmental cues with drugs, and in the left dorsal anterior cingulate, an area implicated in drug craving and relapse to drug-seeking behavior.

Related Article:

In This Issue
Am J Psychiatry 2005 162: A56. [Full Text] [PDF]

This article has been cited by other articles:

				M. M. L. de Win, G. Jager, J. Booij, L. Reneman, T. Schilt, C. Lavini, S. D. Olabarriaga, N. F. Ramsey, G. J. d. Heeten, and W. van den Brink Neurotoxic effects of ecstasy on the thalamus The British Journal of Psychiatry, October 1, 2008; 193(4): 289 - 296. [Abstract] [Full Text] [PDF]

				G. E. Swan and C. N. Lessov-Schlaggar The Genetics of Nicotine Addiction: Current Status and Future Directions ASCO Educational Book, January 1, 2008; 2008(1): 70 - 73. [Abstract] [Full Text] [PDF]

				J. Arehart-Treichel Cigarette Addiction Linked To Two Brain Areas Psychiatr News, April 1, 2005; 40(7): 38 - 38. [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 2005 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us