Full Text Full Text (PDF) Correction (v162,p832) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Tregellas, J. R. Articles by Freedman, R. Search for Related Content PubMed Citation Articles by Tregellas, J. R. Articles by Freedman, R. Nicotine fMR Schizophrenia Spectrum Disorders

fMRI of Response to Nicotine During a Smooth Pursuit Eye Movement Task in Schizophrenia

OBJECTIVE: Nicotine temporarily normalizes smooth pursuit eye movement deficits in schizophrenia. This study used functional magnetic resonance imaging (fMRI) to examine changes in brain hemodynamic response associated with nicotine administration during a smooth pursuit eye movement task in subjects with schizophrenia. METHOD: Nine subjects with schizophrenia performed the eye movement task while undergoing fMRI. Subjects then were given nicotine or placebo and repeated the task while being scanned. Subjects repeated the procedure the following week, receiving the counterbalanced condition. RESULTS: Compared with placebo, nicotine was associated with greater activity in the anterior and posterior cingulate gyri, precuneus, and area MT/MST and less activity in the hippocampus and parietal eye fields. CONCLUSIONS: Changes in area MT/MST and the cingulate gyrus are consistent with an improvement in perception and attention to moving stimuli. The most important observed difference between nicotine and placebo—less activation of the hippocampus after nicotine than after placebo administration—is consistent with nicotinic receptor mediation of inhibitory neuronal dysfunction in schizophrenia.

This article has been cited by other articles:

				L. F. Martin, D. B. Davalos, and M. A. Kisley Nicotine enhances automatic temporal processing as measured by the mismatch negativity waveform Nicotine Tob Res, June 1, 2009; 11(6): 698 - 706. [Abstract] [Full Text] [PDF]

				J. J. Prochaska, S. M. Hall, and L. A. Bero Tobacco Use Among Individuals With Schizophrenia: What Role Has the Tobacco Industry Played? Schizophr Bull, December 10, 2007; (2007) sbm117v2. [Abstract] [Full Text] [PDF]

				G. Winterer, F. Musso, A. Konrad, G. Vucurevic, P. Stoeter, T. Sander, and J. Gallinat Association of attentional network function with exon 5 variations of the CHRNA4 gene Hum. Mol. Genet., September 15, 2007; 16(18): 2165 - 2174. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2005 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us