Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Bonne, O. Articles by Charney, D. S. Search for Related Content PubMed Citation Articles by Bonne, O. Articles by Charney, D. S. Neurophysiology Posttraumatic Stress Disorder

No Change in Serotonin Type 1A Receptor Binding in Patients With Posttraumatic Stress Disorder

OBJECTIVE: Serotonin type 1A receptors (5HT1ARs) have been shown to be affected by stress in experimental animals and related to anxiety and depression in humans. In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD). METHOD: Using positron emission tomography and the radioligand [¹⁸F]FCWAY, the authors compared 5HT1AR binding between patients with PTSD and healthy subjects. RESULTS: No significant differences in 5HT1AR distribution volume, binding potential, or tracer delivery were found. CONCLUSIONS: 5HT1AR expression may not be altered in patients with PTSD.

This article has been cited by other articles:

				Y. H. Ryu, J.-S. Liow, S. Zoghbi, M. Fujita, J. Collins, D. Tipre, J. Sangare, J. Hong, V. W. Pike, and R. B. Innis Disulfiram Inhibits Defluorination of 18F-FCWAY, Reduces Bone Radioactivity, and Enhances Visualization of Radioligand Binding to Serotonin 5-HT1A Receptors in Human Brain J. Nucl. Med., July 1, 2007; 48(7): 1154 - 1161. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2005 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us