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Placebo-Controlled Study of Pimozide Augmentation of Fluoxetine in Body Dysmorphic Disorder

OBJECTIVE: Although body dysmorphic disorder often responds to serotonin reuptake inhibitors (SRIs), most patients do not respond or respond only partially. However, placebo-controlled studies of augmentation of SRIs have not been done. Furthermore, although 40%–50% of patients are delusional, studies of antipsychotic medications have not been done. METHOD: Twenty-eight patients with body dysmorphic disorder or its delusional variant participated in an 8-week, placebo-controlled, double-blind, parallel-group study of pimozide augmentation of fluoxetine. RESULTS: Pimozide was not more effective than placebo: two (18.2%) of 11 subjects responded to pimozide and three (17.6%) of 17 subjects responded to placebo. There was no significant effect of baseline delusionality on endpoint severity of body dysmorphic disorder. Delusionality did not decrease significantly more with pimozide than placebo. CONCLUSIONS: Pimozide augmentation of fluoxetine treatment for body dysmorphic disorder was not more effective than placebo, even in more delusional patients. Further studies of augmentation for SRIs are needed.

This article has been cited by other articles:

				K. A. Phillips, E. R. Didie, J. Feusner, and S. Wilhelm Body Dysmorphic Disorder: Treating an Underrecognized Disorder Am J Psychiatry, September 1, 2008; 165(9): 1111 - 1118. [Full Text] [PDF]

				K. A. PHILLIPS Olanzapine Augmentation of Fluoxetine in Body Dysmorphic Disorder Am J Psychiatry, May 1, 2005; 162(5): 1022 - 1023. [Full Text] [PDF]

				K. A. Phillips Clinical Features and Treatment of Body Dysmorphic Disorder Focus, April 1, 2005; 3(2): 179 - 183. [Abstract] [Full Text] [PDF]

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