Am J Psychiatry 162:1969-1971, October 2005
doi: 10.1176/appi.ajp.162.10.1969
© 2005 American Psychiatric Association
Cognitive Control and Semantics in Schizophrenia: An Integrated Approach
Jessica R. Cohen, B.A.,
Brita Elvevåg, Ph.D., and
Terry E. Goldberg, Ph.D.
OBJECTIVE: The authors tested whether decisions about incongruencies in the representation and processing of semantic knowledge, thought to be related to cognitive control, are selectively impaired in schizophrenia. METHOD: Twenty-four patients with schizophrenia and 24 healthy comparison subjects determined the relative size of paired stimuli as they are in the real world. Stimuli were words or images. Real-world "distance" (size difference between stimuli) was manipulated within pairs, as was "congruency" between real-world and presentation size. RESULTS: Although patients were slower overall, both groups exhibited similar effects of "distance" and "congruency"; the task was easier when the real-world size difference between stimuli was greater and when stimuli were congruent in presentation and real-world size. CONCLUSIONS: Some aspects of the representation of semantic knowledge are preserved in schizophrenia, and patients use this information to control cognition in the same manner as healthy individuals.
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C. Opgen-Rhein, A. H. Neuhaus, C. Urbanek, E. Hahn, T. Sander, and M. Dettling
Executive Attention in Schizophrenic Males and the Impact of COMT Val108/158Met Genotype on Performance on the Attention Network Test
Schizophr Bull,
November 1, 2008;
34(6):
1231 - 1239.
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