Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Bearden, C. E. Articles by Simon, T. J. Search for Related Content PubMed Citation Articles by Bearden, C. E. Articles by Simon, T. J. Genetics Cognition

Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome

OBJECTIVE: The 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) is associated with attentional problems and executive dysfunction, and is one of the highest known risk factors for schizophrenia. These behavioral manifestations of 22q11.2 deletion syndrome could result from haploinsufficiency of the catechol O-methyltransferase (COMT) gene, located within the 22q11 region. The goal of the present study was to examine COMT genotype as a predictor of prefrontal cognitive function in patients with 22q11.2 deletion syndrome. METHOD: Patients with confirmed 22q11.2 deletions (N=44) underwent neurocognitive testing following Val¹⁵⁸Met genotyping (Met hemizygous: N=16; Val hemizygous: N=28). RESULTS: Analyses of covariance revealed that Met-hemizygous patients performed significantly better on a composite measure of executive function (comprising set-shifting, verbal fluency, attention, and working memory) than did Val-hemizygous patients. CONCLUSIONS: These data are consistent with those of previous studies in normal individuals, suggesting that a functional genetic polymorphism in the 22q11 region may influence prefrontal cognition in individuals with COMT haploinsufficiency.

This article has been cited by other articles:

				Y. Takarae, L. Schmidt, F. Tassone, and T. J. Simon Catechol-O-methyltransferase polymorphism modulates cognitive control in children with chromosome 22q11.2 deletion syndrome Cogn Affect Behav Neurosci, March 1, 2009; 9(1): 83 - 90. [Abstract] [PDF]

				C. E. Bearden, T. G.M. van Erp, R. A. Dutton, A. D. Lee, T. J. Simon, T. D. Cannon, B. S. Emanuel, D. McDonald-McGinn, E. H. Zackai, and P. M. Thompson Alterations in Midline Cortical Thickness and Gyrification Patterns Mapped in Children with 22q11.2 Deletions Cereb Cortex, January 1, 2009; 19(1): 115 - 126. [Abstract] [Full Text] [PDF]

				H. C. Mefford, A. J. Sharp, C. Baker, A. Itsara, Z. Jiang, K. Buysse, S. Huang, V. K. Maloney, J. A. Crolla, D. Baralle, et al. Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes N. Engl. J. Med., October 16, 2008; 359(16): 1685 - 1699. [Abstract] [Full Text] [PDF]

				E. Tunbridge, C. Weickert, J. Kleinman, M. Herman, J Chen, B. Kolachana, P. Harrison, and D. Weinberger Catechol-o-Methyltransferase Enzyme Activity and Protein Expression in Human Prefrontal Cortex across the Postnatal Lifespan Cereb Cortex, May 1, 2007; 17(5): 1206 - 1212. [Abstract] [Full Text] [PDF]

				G. Raux, E. Bumsel, B. Hecketsweiler, T. van Amelsvoort, J. Zinkstok, S. Manouvrier-Hanu, C. Fantini, G.-M. M. Breviere, G. Di Rosa, G. Pustorino, et al. Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome Hum. Mol. Genet., January 1, 2007; 16(1): 83 - 91. [Abstract] [Full Text] [PDF]

				E. M. Drabant, A. R. Hariri, A. Meyer-Lindenberg, K. E. Munoz, V. S. Mattay, B. S. Kolachana, M. F. Egan, and D. R. Weinberger Catechol O-methyltransferase Val158Met Genotype and Neural Mechanisms Related to Affective Arousal and Regulation Arch Gen Psychiatry, December 1, 2006; 63(12): 1396 - 1406. [Abstract] [Full Text] [PDF]

				B. Glaser, M. Debbane, C. Hinard, M. A. Morris, S. P. Dahoun, S. E. Antonarakis, and S. Eliez No Evidence for an Effect of COMT Val158Met Genotype on Executive Function in Patients With 22q11 Deletion Syndrome Am J Psychiatry, March 1, 2006; 163(3): 537 - 539. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us