Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Onitsuka, T. Articles by McCarley, R. W. Search for Related Content PubMed Citation Articles by Onitsuka, T. Articles by McCarley, R. W. Schizophrenia Spectrum Disorders MRI Other Neuroanatomy

Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in Chronic Schizophrenia: An MRI Study

OBJECTIVE: The middle temporal gyrus and inferior temporal gyrus subserve language and semantic memory processing, visual perception, and multimodal sensory integration. Functional deficits in these cognitive processes have been well documented in patients with schizophrenia. However, there have been few in vivo structural magnetic resonance imaging (MRI) studies of the middle temporal gyrus and inferior temporal gyrus in schizophrenia. METHOD: Middle temporal gyrus and inferior temporal gyrus gray matter volumes were measured in 23 male patients diagnosed with chronic schizophrenia and 28 healthy male subjects by using high-spatial-resolution MRI. For comparison, superior temporal gyrus and fusiform gyrus gray matter volumes were also measured. Correlations between these four regions and clinical symptoms were also investigated. RESULTS: Relative to healthy subjects, the patients with chronic schizophrenia showed gray matter volume reductions in the left middle temporal gyrus (13% difference) and bilateral inferior temporal gyrus (10% difference in both hemispheres). In addition, the patients showed gray matter volume reductions in the left superior temporal gyrus (13% difference) and bilateral fusiform gyrus (10% difference in both hemispheres). More severe hallucinations were significantly correlated with smaller left hemisphere volumes in the superior temporal gyrus and middle temporal gyrus. CONCLUSIONS: These results suggest that patients with schizophrenia evince reduced gray matter volume in the left middle temporal gyrus and bilateral reductions in the inferior temporal gyrus. In conjunction with findings of left superior temporal gyrus reduction and bilateral fusiform gyrus reductions, these data suggest that schizophrenia may be characterized by left hemisphere-selective dorsal pathophysiology and bilateral ventral pathophysiology in temporal lobe gray matter.

This article has been cited by other articles:

				J. H. Yoon, M. J. Minzenberg, S. Ursu, R. Walters, C. Wendelken, J. D. Ragland, and C. S. Carter Association of Dorsolateral Prefrontal Cortex Dysfunction With Disrupted Coordinated Brain Activity in Schizophrenia: Relationship With Impaired Cognition, Behavioral Disorganization, and Global Function Am J Psychiatry, August 1, 2008; 165(8): 1006 - 1014. [Abstract] [Full Text] [PDF]

				M. Noulhiane, P. Piolino, D. Hasboun, S. Clemenceau, M. Baulac, and S. Samson Autobiographical memory after temporal lobe resection: neuropsychological and MRI volumetric findings Brain, December 1, 2007; 130(12): 3184 - 3199. [Abstract] [Full Text] [PDF]

				V. M. Goghari, K. Rehm, C. S. Carter, and A. W. MacDonald III Regionally Specific Cortical Thinning and Gray Matter Abnormalities in the Healthy Relatives of Schizophrenia Patients Cereb Cortex, February 1, 2007; 17(2): 415 - 424. [Abstract] [Full Text] [PDF]

				N. Kuroki, M. E. Shenton, D. F. Salisbury, Y. Hirayasu, T. Onitsuka, H. Ersner, D. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, and R. W. McCarley Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in First-Episode Schizophrenia: An MRI Study Am J Psychiatry, December 1, 2006; 163(12): 2103 - 2110. [Abstract] [Full Text] [PDF]

				P. D. Butler, M. J. Hoptman, J. Nierenberg, J. J. Foxe, D. C. Javitt, and K. O. Lim Visual White Matter Integrity in Schizophrenia Am J Psychiatry, November 1, 2006; 163(11): 2011 - 2013. [Abstract] [Full Text] [PDF]

				M. Mather, K. J. Mitchell, C. L. Raye, D. L. Novak, E. J. Greene, and M. K. Johnson Emotional arousal can impair feature binding in working memory. J. Cogn. Neurosci., April 1, 2006; 18(4): 614 - 625. [Abstract] [Full Text] [PDF]

				H. Gunduz-Bruce, M. McMeniman, D. G. Robinson, M. G. Woerner, J. M. Kane, N. R. Schooler, and J. A. Lieberman Duration of Untreated Psychosis and Time to Treatment Response for Delusions and Hallucinations Am J Psychiatry, October 1, 2005; 162(10): 1966 - 1969. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us