Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Yang, Y. K. Articles by Lee, I H. Search for Related Content PubMed Citation Articles by Yang, Y. K. Articles by Lee, I H. Neurotransmitters Schizophrenia Spectrum Disorders SPECT

Associated Alterations of Striatal Dopamine D₂/D₃ Receptor and Transporter Binding in Drug-Naive Patients With Schizophrenia: A Dual-Isotope SPECT Study

OBJECTIVE: In vivo imaging studies have revealed deregulated presynaptic or postsynaptic function of the midbrain dopaminergic system in patients with schizophrenia. To further delineate the neuropathological involvement of the presynaptic and postsynaptic dopamine neurons in schizophrenia, the authors examined brain D₂-family receptor and dopamine transporter binding simultaneously in patients with drug-naive schizophrenia using the dual-isotope single photon emission computed tomography (SPECT) imaging technique. METHOD: Eleven patients with schizophrenia and 12 healthy comparison subjects were recruited. Striatal dopamine D₂/D₃ receptor was measured with SPECT and [¹²³I]iodobenzamide ([¹²³I]IBZM), while dopamine transporter was measured with SPECT and [^99mTc]TRODAT-1. RESULTS: Striatal D₂/D₃ receptor and dopamine transporter binding were unaltered in these drug-naive patients with schizophrenia. Nonetheless, D₂/D₃ receptor binding measures were positively correlated with dopamine transporter binding measures in these patients but not in the comparison subjects. CONCLUSIONS: The associated presynaptic and postsynaptic disturbances of midbrain dopamine neurons could be clinically relevant in drug-naive patients with schizophrenia.

This article has been cited by other articles:

				S. Nikolaus, C. Antke, K. Kley, M. Beu, A. Wirrwar, and H.-W. Muller Pretreatment with Haloperidol Reduces 123I-FP-CIT Binding to the Dopamine Transporter in the Rat Striatum: An In Vivo Imaging Study with a Dedicated Small-Animal SPECT Camera J. Nucl. Med., July 1, 2009; 50(7): 1147 - 1152. [Abstract] [Full Text] [PDF]

				G. J. E Schmitt, E. M. Meisenzahl, T. Frodl, C. La Fougere, K. Hahn, H- J. Moller, and S. Dresel The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1 J Psychopharmacol, September 1, 2005; 19(5): 488 - 493. [Abstract] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us