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Basal Ganglia High-Energy Phosphate Metabolism in Neuroleptic-Naive Patients With Schizophrenia: A 31-Phosphorus Magnetic Resonance Spectroscopic Study

OBJECTIVE: This study used 31-phosphorus magnetic resonance spectroscopy (³¹P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia. METHOD: Nineteen schizophrenia patients and 31 age- and sex-matched healthy comparison subjects underwent ³¹P MRS. RESULTS: The phosphocreatine/total phosphorus and phosphocreatine/total ATP ratios in both basal ganglia were significantly lower in patients. CONCLUSIONS: Schizophrenia patients showed features of increased metabolism in the basal ganglia consistent with impaired activity of the frontostriatal pathways.

This article has been cited by other articles:

				A. Konrad and G. Winterer Disturbed Structural Connectivity in Schizophrenia Primary Factor in Pathology or Epiphenomenon? Schizophr Bull, January 1, 2008; 34(1): 72 - 92. [Abstract] [Full Text] [PDF]

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