Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Taylor, W. D. Articles by Krishnan, K. R. R. Search for Related Content PubMed Citation Articles by Taylor, W. D. Articles by Krishnan, K. R. R. Neurodegeneration Geriatric Psychiatry Depression MRI

Late-Life Depression and Microstructural Abnormalities in Dorsolateral Prefrontal Cortex White Matter

OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with 16 elderly subjects who were not depressed. Diffusion tensor imaging was used to measure the fractional anisotropy of the white matter in the dorsolateral prefrontal cortex’s superior and middle frontal gyri bilaterally and in the left occipital lobe as a control region. The authors compared results between groups while controlling for age, sex, and comorbid medical disorders. RESULTS: Even after controlling for age, sex, hypertension, and heart disease, the authors found significantly lower fractional anisotropy values in the right superior frontal gyrus white matter of depressed patients than comparison subjects. CONCLUSIONS: Microstructural changes in the white matter of the right superior frontal gyrus are associated with late-life depression. Further work is needed to determine how these changes contribute to depression outcomes.

This article has been cited by other articles:

				H. Johansen-Berg, D. A. Gutman, T. E. J. Behrens, P. M. Matthews, M. F. S. Rushworth, E. Katz, A. M. Lozano, and H. S. Mayberg Anatomical Connectivity of the Subgenual Cingulate Region Targeted with Deep Brain Stimulation for Treatment-Resistant Depression Cereb Cortex, June 1, 2008; 18(6): 1374 - 1383. [Abstract] [Full Text] [PDF]

				F. M. Gunning-Dixon, M. J. Hoptman, K. O. Lim, C. F. Murphy, S. Klimstra, V. Latoussakis, M. Majcher-Tascio, J. Hrabe, B. A. Ardekani, and G. S. Alexopoulos Macromolecular White Matter Abnormalities in Geriatric Depression: A Magnetization Transfer Imaging Study Am J Geriatr Psychiatry, April 1, 2008; 16(4): 255 - 262. [Abstract] [Full Text] [PDF]

				A. Kumar and O. Ajilore Magnetic Resonance Imaging and Late-Life Depression: Potential Biomarkers in the Era of Personalized Medicine Am J Psychiatry, February 1, 2008; 165(2): 166 - 168. [Full Text] [PDF]

				G. S. Alexopoulos, C. F. Murphy, F. M. Gunning-Dixon, V. Latoussakis, D. Kanellopoulos, S. Klimstra, K. O. Lim, and M. J. Hoptman Microstructural White Matter Abnormalities and Remission of Geriatric Depression Am J Psychiatry, February 1, 2008; 165(2): 238 - 244. [Abstract] [Full Text] [PDF]

				S. H. Lisanby Electroconvulsive Therapy for Depression N. Engl. J. Med., November 8, 2007; 357(19): 1939 - 1945. [Full Text] [PDF]

				P. G. P. Nucifora, R. Verma, S.-K. Lee, and E. R. Melhem Diffusion-Tensor MR Imaging and Tractography: Exploring Brain Microstructure and Connectivity Radiology, November 1, 2007; 245(2): 367 - 384. [Abstract] [Full Text] [PDF]

				W. D. Taylor, J. N. Bae, J. R. MacFall, M. E. Payne, J. M. Provenzale, D. C. Steffens, and K. R. R. Krishnan Widespread Effects of Hyperintense Lesions on Cerebral White Matter Structure Am. J. Roentgenol., June 1, 2007; 188(6): 1695 - 1704. [Abstract] [Full Text] [PDF]

				N. Ma, L. Li, N. Shu, J. Liu, G. Gong, Z. He, Z. Li, L. Tan, W. S. Stone, Z. Zhang, et al. White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder Am J Psychiatry, May 1, 2007; 164(5): 823 - 826. [Abstract] [Full Text] [PDF]

				R. Hashimoto, T. Numakawa, T. Ohnishi, E. Kumamaru, Y. Yagasaki, T. Ishimoto, T. Mori, K. Nemoto, N. Adachi, A. Izumi, et al. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling Hum. Mol. Genet., October 15, 2006; 15(20): 3024 - 3033. [Abstract] [Full Text] [PDF]

				M. J. Hoptman, F. M. Gunning-Dixon, C. F. Murphy, K. O. Lim, and G. S. Alexopoulos Structural Neuroimaging Research Methods in Geriatric Depression Am J Geriatr Psychiatry, October 1, 2006; 14(10): 812 - 822. [Abstract] [Full Text] [PDF]

				K Nobuhara, G Okugawa, T Sugimoto, T Minami, C Tamagaki, K Takase, Y Saito, S Sawada, and T Kinoshita Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study J. Neurol. Neurosurg. Psychiatry, January 1, 2006; 77(1): 120 - 122. [Abstract] [Full Text] [PDF]

				D. K. Jones, M. Catani, C. Pierpaoli, S. J. Reeves, S. S. Shergill, M. O'Sullivan, P. Maguire, M. A. Horsfield, A. Simmons, S. C.R. Williams, et al. A Diffusion Tensor Magnetic Resonance Imaging Study of Frontal Cortex Connections in Very-Late-Onset Schizophrenia-Like Psychosis Am J Geriatr Psychiatry, December 1, 2005; 13(12): 1092 - 1099. [Abstract] [Full Text] [PDF]

				D. C. Steffens Research in Geriatric Depression: A Model for Mental Health Research in the 21st Century? Am J Geriatr Psychiatry, October 1, 2005; 13(10): 829 - 833. [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us