Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Wisner, K. L. Articles by Findling, R. L. Search for Related Content PubMed Citation Articles by Wisner, K. L. Articles by Findling, R. L. Gender Depression Antidepressants

Prevention of Postpartum Depression: A Pilot Randomized Clinical Trial

OBJECTIVE: The authors attempted to reduce the rate of postpartum depression in high-risk women and to increase the time to recurrence. METHOD: Nondepressed pregnant women with at least one past episode of postpartum major depression were recruited into a randomized clinical trial. Mothers were assigned randomly to a 17-week trial of sertraline or placebo immediately after birth and assessed for 20 sequential weeks with the Hamilton Rating Scale for Depression. RESULTS: Of 14 subjects who took sertraline, one (7%) suffered a recurrence. Of eight subjects who were assigned to placebo, four (50%) suffered recurrences. This difference was significant. The time to recurrence was significantly longer in the sertraline-treated women than in the placebo-treated women. CONCLUSIONS: Sertraline conferred preventive efficacy for postpartum-onset major depression beyond that of placebo.

This article has been cited by other articles:

				J. L. Payne Antidepressant Use in the Postpartum Period: Practical Considerations Am J Psychiatry, September 1, 2007; 164(9): 1329 - 1332. [Full Text] [PDF]

				P. K. Mallikarjun and F. Oyebode Prevention of postnatal depression The Journal of the Royal Society for the Promotion of Health, September 1, 2005; 125(5): 221 - 226. [Abstract] [PDF]

				Postpartum Depression: Promise of Prevention Journal Watch Psychiatry, October 21, 2004; 2004(1021): 11 - 11. [Full Text]

				Postpartum Depression: Promise of Prevention Journal Watch Women's Health, August 24, 2004; 2004(824): 7 - 7. [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us