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Weight and Leptin Changes Among Risperidone-Treated Youths With Autism: 6-Month Prospective Data

OBJECTIVE: The authors examined the developmental impact and temporal characteristics of risperidone-associated weight change. METHOD: Weight change was measured for 63 children and adolescents with autism treated with risperidone for 6 months. Change in serum leptin levels after 2 months was examined as a predictor of final weight gain in mixed regression models that controlled for site, gender, age, and risperidone dose. RESULTS: Age- and gender-standardized weight increased after 6 months of treatment (gross: mean=5.6 kg [SD=3.9]; standardized: mean=0.6 z [SD=0.5]) and was positively correlated with weight gained after 1 month. Change in leptin levels after 2 months of treatment (mean=–0.3 ng/ml, SD=6.2) (N=48) did not predict final weight gain. CONCLUSIONS: Chronic risperidone exposure in children with autism causes weight gain in excess of developmentally expected norms that follows a curvilinear trajectory and decelerates over time. Serum leptin change does not reliably predict risperidone-associated weight gain.

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				B. Vitiello Risperidone maintenance treatment increases time to symptom recurrence in young people with disruptive behaviour disorders. Evid. Based Ment. Health, November 1, 2006; 9(4): 105 - 105. [Full Text] [PDF]

				Research Units on Pediatric Psychopharmacology Aut Risperidone Treatment of Autistic Disorder: Longer-Term Benefits and Blinded Discontinuation After 6 Months Am J Psychiatry, July 1, 2005; 162(7): 1361 - 1369. [Abstract] [Full Text] [PDF]

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