Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Cohen, H. Articles by Grisaru, N. Search for Related Content PubMed Citation Articles by Cohen, H. Articles by Grisaru, N. Posttraumatic Stress Disorder Other Somatic Therapy

Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in Posttraumatic Stress Disorder: A Double-Blind, Placebo-Controlled Study

OBJECTIVE: The efficacy of repetitive transcranial magnetic stimulation (rTMS) of the right prefrontal cortex was studied in patients with posttraumatic stress disorder (PTSD) under double-blind, placebo-controlled conditions. METHOD: Twenty-four patients with PTSD were randomly assigned to receive rTMS at low frequency (1 Hz) or high frequency (10 Hz) or sham rTMS in a double-blind design. Treatment was administered in 10 daily sessions over 2 weeks. Severity of PTSD, depression, and anxiety were blindly assessed before, during, and after completion of the treatment protocol. RESULTS: The 10 daily treatments of 10-Hz rTMS at 80% motor threshold over the right dorsolateral prefrontal cortex had therapeutic effects on PTSD patients. PTSD core symptoms (reexperiencing, avoidance) markedly improved with this treatment. Moreover, high-frequency rTMS over the right dorsolateral prefrontal cortex alleviated anxiety symptoms in PTSD patients. CONCLUSIONS: This double-blind, controlled trial suggests that in PTSD patients, 10 daily sessions of right dorsolateral prefrontal rTMS at a frequency of 10 Hz have greater therapeutic effects than slow-frequency or sham stimulation.

This article has been cited by other articles:

				H. Ben-Zur and M. Zeidner Threat to Life and Risk-Taking Behaviors: A Review of Empirical Findings and Explanatory Models Personality and Social Psychology Review, May 1, 2009; 13(2): 109 - 128. [Abstract] [PDF]

				F. Schiffer, I. Glass, J. Lord, and M. H. Teicher Prediction of Clinical Outcomes From rTMS in Depressed Patients With Lateral Visual Field Stimulation: A Replication J Neuropsychiatry Clin Neurosci, May 1, 2008; 20(2): 194 - 200. [Abstract] [Full Text] [PDF]

				P. M. Rossini and S. Rossi Transcranial magnetic stimulation: Diagnostic, therapeutic, and research potential Neurology, February 13, 2007; 68(7): 484 - 488. [Abstract] [Full Text] [PDF]

				H. J. GIJSMAN Mania After Transcranial Magnetic Stimulation in PTSD Am J Psychiatry, February 1, 2005; 162(2): 398 - 398. [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us