Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Buchanan, R. W. Articles by Pearlson, G. D. Search for Related Content PubMed Citation Articles by Buchanan, R. W. Articles by Pearlson, G. D. Neurodegeneration Schizophrenia Spectrum Disorders MRI

Morphometric Assessment of the Heteromodal Association Cortex in Schizophrenia

OBJECTIVE: The heteromodal association cortex has been hypothesized to be selectively involved in the pathophysiology of schizophrenia. To test this hypothesis, the authors measured prefrontal, inferior parietal, and superior temporal gyrus volumes and examined the pattern of connections among these regions. METHOD: Forty-four patients with schizophrenia or schizoaffective disorder and 34 healthy comparison subjects were included in the study. A spoiled gradient recall acquisition in the steady-state three-dimensional magnetic resonance imaging sequence was used for morphometric assessment of the heteromodal association cortex. RESULTS: Patients with schizophrenia had significantly smaller inferior prefrontal region volumes and significant reversal of the normal asymmetry of the inferior parietal cortex. No significant group differences were found in superior temporal gyrus volume. The groups differed significantly in the correlation between inferior prefrontal region volumes and angular gyrus volumes. CONCLUSIONS: The results suggest that patients with schizophrenia may be characterized by selective abnormalities of the heteromodal regions involved in the neuroanatomy of language.

This article has been cited by other articles:

				Z. J. Chen, Y. He, P. Rosa-Neto, J. Germann, and A. C. Evans Revealing Modular Architecture of Human Brain Structural Networks by Using Cortical Thickness from MRI Cereb Cortex, February 10, 2008; (2008) bhn003v1. [Abstract] [Full Text] [PDF]

				M. Suzuki, S.-Y. Zhou, T. Takahashi, H. Hagino, Y. Kawasaki, L. Niu, M. Matsui, H. Seto, and M. Kurachi Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis Brain, September 1, 2005; 128(9): 2109 - 2122. [Abstract] [Full Text] [PDF]

				J. Nierenberg, D. F. Salisbury, J. J. Levitt, E. A. David, R. W. McCarley, and M. E. Shenton Reduced Left Angular Gyrus Volume in First-Episode Schizophrenia Am J Psychiatry, August 1, 2005; 162(8): 1539 - 1541. [Abstract] [Full Text] [PDF]

				R. GREEN Heteromodal Association Cortex in Schizophrenia Am J Psychiatry, September 1, 2004; 161(9): 1723 - 1724. [Full Text] [PDF]

				N. Gogtay, J. N. Giedd, L. Lusk, K. M. Hayashi, D. Greenstein, A. C. Vaituzis, T. F. Nugent III, D. H. Herman, L. S. Clasen, A. W. Toga, et al. From the Cover: Dynamic mapping of human cortical development during childhood through early adulthood PNAS, May 25, 2004; 101(21): 8174 - 8179. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us