Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Ballmaier, M. Articles by Kumar, A. Search for Related Content PubMed Citation Articles by Ballmaier, M. Articles by Kumar, A. Depression MRI Neurodegeneration

Anterior Cingulate, Gyrus Rectus, and Orbitofrontal Abnormalities in Elderly Depressed Patients: An MRI-Based Parcellation of the Prefrontal Cortex

OBJECTIVE: To examine structural abnormalities in subregions of the prefrontal cortex in elderly patients with depression, the authors explored differences in gray matter, white matter, and CSF volumes by applying a parcellation method based on magnetic resonance imaging (MRI). METHOD: Twenty-four elderly patients with major depression and 19 group-matched comparison subjects were studied with high-resolution MRI. Cortical surface extraction, tissue segmentation, and cortical parcellation methods were applied to obtain volume measures of gray matter, white matter, and CSF in seven prefrontal subregions: the anterior cingulate, gyrus rectus, orbitofrontal cortex, precentral gyrus, superior frontal cortex, middle frontal cortex, and inferior frontal cortex. RESULTS: Highly significant bilateral volume reductions in gray matter were observed in the anterior cingulate, the gyrus rectus, and the orbitofrontal cortex. Depressed patients also exhibited significant bilateral white matter volume reductions and significant CSF volume increases in the anterior cingulate and the gyrus rectus. Finally, the depressed group showed significant CSF volume reductions in the orbitofrontal cortex relative to the comparison subjects. None of the other regions examined revealed significant structural abnormalities. CONCLUSIONS: The prominent bilateral gray matter deficits in the anterior cingulate and the gyrus rectus as well as the orbitofrontal cortex may reflect disease-specific modifications of elderly depression. The differential pattern of abnormalities detected in the white matter and CSF compartments imply that distinct etiopathological mechanisms might underlie the structural cortical changes in these regions.

This article has been cited by other articles:

				M. B. H. Yap, S. Whittle, M. Yucel, L. Sheeber, C. Pantelis, J. G. Simmons, and N. B. Allen Interaction of Parenting Experiences and Brain Structure in the Prediction of Depressive Symptoms in Adolescents Arch Gen Psychiatry, December 1, 2008; 65(12): 1377 - 1385. [Abstract] [Full Text] [PDF]

				C. A. Smith, G. T. Stebbins, R. E. Bartt, H. A. Kessler, O. M. Adeyemi, E. Martin, R. Bammer, and M. E. Moseley White Matter Anisotropy and Depression Symptoms in Patients with HIV J Neuropsychiatry Clin Neurosci, November 1, 2008; 20(4): 458 - 465. [Abstract] [Full Text] [PDF]

				M. Ballmaier, K. L. Narr, A. W. Toga, V. Elderkin-Thompson, P. M. Thompson, L. Hamilton, E. Haroon, D. Pham, A. Heinz, and A. Kumar Hippocampal Morphology and Distinguishing Late-Onset From Early-Onset Elderly Depression Am J Psychiatry, February 1, 2008; 165(2): 229 - 237. [Abstract] [Full Text] [PDF]

				M. Nakamura, P. G. Nestor, J. J. Levitt, A. S. Cohen, T. Kawashima, M. E. Shenton, and R. W. McCarley Orbitofrontal volume deficit in schizophrenia and thought disorder Brain, January 1, 2008; 131(1): 180 - 195. [Abstract] [Full Text] [PDF]

				J. J. Cerqueira, R. Taipa, H. B. M. Uylings, O. F. X. Almeida, and N. Sousa Specific Configuration of Dendritic Degeneration in Pyramidal Neurons of the Medial Prefrontal Cortex Induced by Differing Corticosteroid Regimens Cereb Cortex, September 1, 2007; 17(9): 1998 - 2006. [Abstract] [Full Text] [PDF]

				N. Ma, L. Li, N. Shu, J. Liu, G. Gong, Z. He, Z. Li, L. Tan, W. S. Stone, Z. Zhang, et al. White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder Am J Psychiatry, May 1, 2007; 164(5): 823 - 826. [Abstract] [Full Text] [PDF]

				Y. YANG, A. RAINE, K. L. NARR, T. LENCZ, L. LaCASSE, P. COLLETTI, and A. W. TOGA Localisation of increased prefrontal white matter in pathological liars The British Journal of Psychiatry, February 1, 2007; 190(2): 174 - 175. [Abstract] [Full Text] [PDF]

				C. I. Wright, D. Williams, E. Feczko, L. F. Barrett, B. C. Dickerson, C. E. Schwartz, and M. M. Wedig Neuroanatomical Correlates of Extraversion and Neuroticism Cereb Cortex, December 1, 2006; 16(12): 1809 - 1819. [Abstract] [Full Text] [PDF]

				R. Hashimoto, T. Numakawa, T. Ohnishi, E. Kumamaru, Y. Yagasaki, T. Ishimoto, T. Mori, K. Nemoto, N. Adachi, A. Izumi, et al. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling Hum. Mol. Genet., October 15, 2006; 15(20): 3024 - 3033. [Abstract] [Full Text] [PDF]

				B. Iordanova, D. Rosenbaum, D. Norman, M. Weiner, and C. Studholme MR Imaging Anatomy in Neurodegeneration: A Robust Volumetric Parcellation Method of the Frontal Lobe Gyri with Quantitative Validation in Patients with Dementia. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1747 - 1754. [Abstract] [Full Text] [PDF]

				S. Cervenka, S. E. Palhagen, R. A. Comley, G. Panagiotidis, Z. Cselenyi, J. C. Matthews, R. Y. Lai, C. Halldin, and L. Farde Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding Brain, August 1, 2006; 129(8): 2017 - 2028. [Abstract] [Full Text] [PDF]

				A. M. J. MacLullich, K. J. Ferguson, J. M. Wardlaw, J. M. Starr, I. J. Deary, and J. R. Seckl Smaller Left Anterior Cingulate Cortex Volumes Are Associated with Impaired Hypothalamic-Pituitary-Adrenal Axis Regulation in Healthy Elderly Men J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1591 - 1594. [Abstract] [Full Text] [PDF]

				D. C. Steffens, E. Otey, G. S. Alexopoulos, M. A. Butters, B. Cuthbert, M. Ganguli, Y. E. Geda, H. C. Hendrie, R. R. Krishnan, A. Kumar, et al. Perspectives on Depression, Mild Cognitive Impairment, and Cognitive Decline Arch Gen Psychiatry, February 1, 2006; 63(2): 130 - 138. [Abstract] [Full Text] [PDF]

				M. A. Rapp, K. Dahlman, M. Sano, H. T. Grossman, V. Haroutunian, and J. M. Gorman Neuropsychological Differences Between Late-Onset and Recurrent Geriatric Major Depression Am J Psychiatry, April 1, 2005; 162(4): 691 - 698. [Abstract] [Full Text] [PDF]

				M. Ballmaier, A. Kumar, P. M. Thompson, K. L. Narr, H. Lavretsky, L. Estanol, H. DeLuca, and A. W. Toga Localizing Gray Matter Deficits in Late-Onset Depression Using Computational Cortical Pattern Matching Methods Am J Psychiatry, November 1, 2004; 161(11): 2091 - 2099. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us