Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Bhagwagar, Z. Articles by Harmer, C. J. Search for Related Content PubMed Citation Articles by Bhagwagar, Z. Articles by Harmer, C. J. Depression Antidepressants

Normalization of Enhanced Fear Recognition by Acute SSRI Treatment in Subjects With a Previous History of Depression

OBJECTIVE: The present study aimed to 1) assess facial expression recognition in subjects with a previous history of major depressive disorder relative to subjects with no history of depression and 2) characterize the effects of acute citalopram infusion on recognition performance for both groups. METHOD: Unmedicated euthymic women with a history of major depression and matched comparison subjects with no history of depression were given a facial expression recognition task following intravenous infusion of saline or citalopram (10 mg) in a double-blind, between-group design. RESULTS: Following saline infusion, subjects with a previous history of depression showed a selectively greater recognition of fear relative to the subjects with no history of depression. The abnormal fear processing observed in the subjects with a previous history of depression was normalized following citalopram infusion, an effect that was opposite to that seen with the subjects with no history of depression. CONCLUSIONS: These results suggest that increased recognition of fear is a trait vulnerability marker for depression and that this is normalized following a single dose of citalopram.

This article has been cited by other articles:

				S. E. Murphy, R. Norbury, U. O'Sullivan, P. J. Cowen, and C. J. Harmer Effect of a single dose of citalopram on amygdala response to emotional faces The British Journal of Psychiatry, June 1, 2009; 194(6): 535 - 540. [Abstract] [Full Text] [PDF]

				W. Merens, L. Booij, P. J. Haffmans, and A. van der Does The effects of experimentally lowered serotonin function on emotional information processing and memory in remitted depressed patients J Psychopharmacol, August 1, 2008; 22(6): 653 - 662. [Abstract] [PDF]

				S. HAFIZI, P. CHANDRA, and J. COWEN Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations The British Journal of Psychiatry, October 1, 2007; 191(4): 282 - 284. [Abstract] [Full Text] [PDF]

				M. J. Taylor, N. Freemantle, J. R. Geddes, and Z. Bhagwagar Early Onset of Selective Serotonin Reuptake Inhibitor Antidepressant Action: Systematic Review and Meta-analysis. Arch Gen Psychiatry, November 1, 2006; 63(11): 1217 - 1223. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us