Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Gaser, C. Articles by Buchsbaum, M. S. Search for Related Content PubMed Citation Articles by Gaser, C. Articles by Buchsbaum, M. S. Schizophrenia Spectrum Disorders Neurodegeneration

Ventricular Enlargement in Schizophrenia Related to Volume Reduction of the Thalamus, Striatum, and Superior Temporal Cortex

OBJECTIVE: Enlargement of the lateral ventricles is among the most frequently reported macroscopic brain structural changes in schizophrenia, although variable in extent and localization. The authors investigated whether ventricular enlargement is related to regionally specific volume loss. METHOD: High-resolution magnetic resonance imaging scans from 39 patients with schizophrenia were analyzed with deformation-based morphometry, a voxel-wise whole brain morphometric technique. RESULTS: Significant negative correlations with the ventricle-brain ratio were found for voxels in the left and right thalamus and posterior putamen and in the left superior temporal gyrus and insula. CONCLUSIONS: Thalamic shrinkage, especially of medial nuclei and the adjacent striatum and insular cortex, appear to be important contributors to ventricular enlargement in schizophrenia.

This article has been cited by other articles:

				M.-S. Koo, C. C. Dickey, H.-J. Park, M. Kubicki, N. Y. Ji, S. Bouix, K. M. Pohl, J. J. Levitt, M. Nakamura, M. E. Shenton, et al. Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder. Arch Gen Psychiatry, October 1, 2006; 63(10): 1090 - 1100. [Abstract] [Full Text] [PDF]

				C. Davatzikos, D. Shen, R. C. Gur, X. Wu, D. Liu, Y. Fan, P. Hughett, B. I. Turetsky, and R. E. Gur Whole-Brain Morphometric Study of Schizophrenia Revealing a Spatially Complex Set of Focal Abnormalities Arch Gen Psychiatry, November 1, 2005; 62(11): 1218 - 1227. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2004 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us