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High Blood Monocyte Counts and Neopterin Levels in Children With Autistic Disorder

OBJECTIVE: Leukocyte counts and plasma neopterin levels were determined in autistic children and matched healthy comparison subjects. METHOD: Blood from 31 autistic children and 28 age- and gender-matched healthy comparison subjects was analyzed for numbers of neutrophils, eosinophils, basophils, lymphocytes, monocytes, and total leukocytes and for plasma neopterin levels. RESULTS: The monocyte count and neopterin level were significantly higher in the autistic children than in the comparison subjects. CONCLUSIONS: These results suggest that the immune system may be activated in some children with autism.

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				P. Ashwood, S. Wills, and J. Van de Water The immune response in autism: a new frontier for autism research J. Leukoc. Biol., July 1, 2006; 80(1): 1 - 15. [Abstract] [Full Text] [PDF]

				T. L. Sweeten, S. L. Bowyer, D. J. Posey, G. M. Halberstadt, and C. J. McDougle Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders Pediatrics, November 1, 2003; 112(5): e420 - 420. [Abstract] [Full Text] [PDF]

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