Am J Psychiatry 160:1041-1052, June 2003
© 2003 American Psychiatric Association
Developmental Neurocircuitry of Motivation in Adolescence: A Critical Period of Addiction Vulnerability
R. Andrew Chambers, M.D.,
Jane R. Taylor, Ph.D., and
Marc N. Potenza, M.D., Ph.D.
OBJECTIVE: Epidemiological studies indicate that experimentation with addictive drugs and onset of addictive disorders is primarily concentrated in adolescence and young adulthood. The authors describe basic and clinical data supporting adolescent neurodevelopment as a biologically critical period of greater vulnerability for experimentation with substances and acquisition of substance use disorders. METHOD: The authors reviewed recent literature regarding neurocircuitry underlying motivation, impulsivity, and addiction, with a focus on studies investigating adolescent neurodevelopment. RESULTS: Adolescent neurodevelopment occurs in brain regions associated with motivation, impulsivity, and addiction. Adolescent impulsivity and/or novelty seeking as a transitional trait behavior can be explained in part by maturational changes in frontal cortical and subcortical monoaminergic systems. These developmental processes may advantageously promote learning drives for adaptation to adult roles but may also confer greater vulnerability to the addictive actions of drugs. CONCLUSIONS: An exploration of developmental changes in neurocircuitry involved in impulse control has significant implications for understanding adolescent behavior, addiction vulnerability, and the prevention of addiction in adolescence and adulthood.
This article has been cited by other articles:
|
|
|
|
 
P. J. Gianaros, S. B. Manuck, L. K. Sheu, D. C. H. Kuan, E. Votruba-Drzal, A. E. Craig, and A. R. Hariri
Parental Education Predicts Corticostriatal Functionality in Adulthood
Cereb Cortex,
September 1, 2010;
(2010)
bhq160v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Asato, R. Terwilliger, J. Woo, and B. Luna
White Matter Development in Adolescence: A DTI Study
Cereb Cortex,
September 1, 2010;
20(9):
2122 - 2131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. King and R. A. Vidourek
Psychosocial Factors Associated With Recent Alcohol Use Among Hispanic Youth
Hispanic Journal of Behavioral Sciences,
August 1, 2010;
32(3):
470 - 485.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. F. Geier, R. Terwilliger, T. Teslovich, K. Velanova, and B. Luna
Immaturities in Reward Processing and Its Influence on Inhibitory Control in Adolescence
Cereb Cortex,
July 1, 2010;
20(7):
1613 - 1629.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. F. Leeman, T. S. Schepis, D. A. Cavallo, A. K. McFetridge, T. B. Liss, and S. Krishnan-Sarin
Nicotine dependence severity as a cross-sectional predictor of alcohol-related problems in a sample of adolescent smokers
Nicotine Tob Res,
May 1, 2010;
12(5):
521 - 524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Committee on Substance Abuse
Alcohol Use by Youth and Adolescents: A Pediatric Concern
Pediatrics,
May 1, 2010;
125(5):
1078 - 1087.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Nasrallah, T. W. H. Yang, and I. L. Bernstein
From the Cover: Long-term risk preference and suboptimal decision making following adolescent alcohol use
PNAS,
October 13, 2009;
106(41):
17600 - 17604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. L. Gourley, A. J. Koleske, and J. R. Taylor
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
PNAS,
September 29, 2009;
106(39):
16859 - 16864.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. P. Van Zundert, E. A. Boogerd, A. A. Vermulst, and R. C. M. E. Engels
Nicotine withdrawal symptoms following a quit attempt: An ecological momentary assessment study among adolescents
Nicotine Tob Res,
June 1, 2009;
11(6):
722 - 729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. M. Aklin, E. T. Moolchan, D. A. Luckenbaugh, and M. Ernst
Early tobacco smoking in adolescents with externalizing disorders: Inferences for reward function
Nicotine Tob Res,
June 1, 2009;
11(6):
750 - 755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. L. Steeves, J. Miyasaki, M. Zurowski, A. E. Lang, G. Pellecchia, T. Van Eimeren, P. Rusjan, S. Houle, and A. P. Strafella
Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
Brain,
May 1, 2009;
132(5):
1376 - 1385.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Cilia, C. Siri, G. Marotta, I. U. Isaias, D. De Gaspari, M. Canesi, G. Pezzoli, and A. Antonini
Functional Abnormalities Underlying Pathological Gambling in Parkinson Disease
Arch Neurol,
December 1, 2008;
65(12):
1604 - 1611.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. N Potenza
The neurobiology of pathological gambling and drug addiction: an overview and new findings
Phil Trans R Soc B,
October 12, 2008;
363(1507):
3181 - 3189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. C. Brenhouse, K. C. Sonntag, and S. L. Andersen
Transient D1 Dopamine Receptor Expression on Prefrontal Cortex Projection Neurons: Relationship to Enhanced Motivational Salience of Drug Cues in Adolescence
J. Neurosci.,
March 5, 2008;
28(10):
2375 - 2382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Leslie MD
Youth substance use and abuse: challenges and strategies for identification and intervention
Can. Med. Assoc. J.,
January 15, 2008;
178(2):
145 - 148.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Johnson, S. Cen, P. Gallaher, P. H. Palmer, L. Xiao, A. Ritt-Olson, and J. B. Unger
Why Smoking Prevention Programs Sometimes Fail. Does Effectiveness Depend on Sociocultural Context and Individual Characteristics?
Cancer Epidemiol. Biomarkers Prev.,
June 1, 2007;
16(6):
1043 - 1049.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. Riggs, K.-L. K. Sakuma, and M. A. Pentz
Preventing Risk for Obesity by Promoting Self-Regulation and Decision-Making Skills: Pilot Results From the PATHWAYS to Health Program (PATHWAYS)
Eval Rev,
June 1, 2007;
31(3):
287 - 310.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Steinberg
Risk Taking in Adolescence: New Perspectives From Brain and Behavioral Science
Current Directions in Psychological Science,
April 1, 2007;
16(2):
55 - 59.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. N. Potenza
To Do or Not To Do? The Complexities of Addiction, Motivation, Self-Control, and Impulsivity
Am J Psychiatry,
January 1, 2007;
164(1):
4 - 6.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Wilens
Attention Deficit Hyperactivity Disorder and Substance Use Disorders
Am J Psychiatry,
December 1, 2006;
163(12):
2059 - 2063.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. E Wainwright and J. Colombo
Nutrition and the development of cognitive functions: interpretation of behavioral studies in animals and human infants.
Am. J. Clinical Nutrition,
November 1, 2006;
84(5):
961 - 970.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. F. Reyna and F. Farley
Risk and Rationality in Adolescent Decision Making: Implications for Theory, Practice, and Public Policy
Psychological Science in the Public Interest,
September 1, 2006;
7(1):
1 - 44.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Wilens and J. Biederman
Alcohol, drugs, and attention-deficit/ hyperactivity disorder: a model for the study of addictions in youth
J Psychopharmacol,
July 1, 2006;
20(4):
580 - 588.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Knoch, L. R. R. Gianotti, A. Pascual-Leone, V. Treyer, M. Regard, M. Hohmann, and P. Brugger
Disruption of right prefrontal cortex by low-frequency repetitive transcranial magnetic stimulation induces risk-taking behavior.
J. Neurosci.,
June 14, 2006;
26(24):
6469 - 6472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Moffitt, A. Caspi, and M. Rutter
Measured Gene-Environment Interactions in Psychopathology: Concepts, Research Strategies, and Implications for Research, Intervention, and Public Understanding of Genetics
Perspectives on Psychological Science,
March 1, 2006;
1(1):
5 - 27.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. Evans, A. D. Lawrence, J. Potts, S. Appel, and A. J. Lees
Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease
Neurology,
November 22, 2005;
65(10):
1570 - 1574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Joffe and for the Committees on Substance Abuse and Adolesce
Response to the American Academy of Pediatrics Report on Legalization of Marijuana: In Reply
Pediatrics,
November 1, 2005;
116(5):
1257 - 1257.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Dawes and B. A. Johnson
PHARMACOTHERAPEUTIC TRIALS IN ADOLESCENT ALCOHOL USE DISORDERS: OPPORTUNITIES AND CHALLENGES
Alcohol Alcohol.,
May 1, 2004;
39(3):
166 - 177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Bjork, B. Knutson, G. W. Fong, D. M. Caggiano, S. M. Bennett, and D. W. Hommer
Incentive-Elicited Brain Activation in Adolescents: Similarities and Differences from Young Adults
J. Neurosci.,
February 25, 2004;
24(8):
1793 - 1802.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 2003
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
