Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Hendrick, V. Articles by Haynes, D. Search for Related Content PubMed Citation Articles by Hendrick, V. Articles by Haynes, D. Gender Depression Antidepressants

Placental Passage of Antidepressant Medications

OBJECTIVE: This study determined the placental transfer of antidepressants and their metabolites. METHOD: A total of 38 pregnant women taking citalopram, fluoxetine, paroxetine, or sertraline participated. Maternal and umbilical cord blood samples were obtained to determine antidepressant and metabolite concentrations. RESULTS: Antidepressant and metabolite concentrations were detectable in 86.8% of umbilical cord samples. The mean ratios of umbilical cord to maternal serum concentrations ranged from 0.29 to 0.89. The lowest ratios were for sertraline and paroxetine; the highest were for citalopram and fluoxetine. Maternal doses of sertraline and fluoxetine correlated with umbilical cord concentrations of these medications. CONCLUSIONS: Umbilical cord concentrations of antidepressants and their metabolites were almost invariably lower than corresponding maternal concentrations. Maternal doses predicted umbilical concentrations of fluoxetine and sertraline. Mean umbilical cord to maternal serum ratios were significantly lower for sertraline than fluoxetine, suggesting that sertraline may produce less fetal medication exposure than fluoxetine near delivery.

This article has been cited by other articles:

				D. J. Newport, M. R. Calamaras, C. L. DeVane, J. Donovan, A. J. Beach, S. Winn, B. T. Knight, B. B. Gibson, A. C. Viguera, M. J. Owens, et al. Atypical Antipsychotic Administration During Late Pregnancy: Placental Passage and Obstetrical Outcomes Am J Psychiatry, August 1, 2007; 164(8): 1214 - 1220. [Abstract] [Full Text] [PDF]

				K. J. Looper Potential Medical and Surgical Complications of Serotonergic Antidepressant Medications Psychosomatics, February 1, 2007; 48(1): 1 - 9. [Abstract] [Full Text] [PDF]

				E. Ferreira, A. M. Carceller, C. Agogue, B. Z. Martin, M. St-Andre, D. Francoeur, and A. Berard Effects of Selective Serotonin Reuptake Inhibitors and Venlafaxine During Pregnancy in Term and Preterm Neonates Pediatrics, January 1, 2007; 119(1): 52 - 59. [Abstract] [Full Text] [PDF]

				L. M. Bodnar, K. R. Sunder, and K. L. Wisner Treatment With Selective Serotonin Reuptake Inhibitors During Pregnancy: Deceleration of Weight Gain Because of Depression or Drug? Am J Psychiatry, June 1, 2006; 163(6): 986 - 991. [Full Text] [PDF]

				R. Levinson-Castiel, P. Merlob, N. Linder, L. Sirota, and G. Klinger Neonatal Abstinence Syndrome After In Utero Exposure to Selective Serotonin Reuptake Inhibitors in Term Infants Arch Pediatr Adolesc Med, February 1, 2006; 160(2): 173 - 176. [Abstract] [Full Text] [PDF]

				A. M. Loughhead, A. D. Fisher, D. J. Newport, J. C. Ritchie, M. J. Owens, C. L. DeVane, and Z. N. Stowe Antidepressants in Amniotic Fluid: Another Route of Fetal Exposure Am J Psychiatry, January 1, 2006; 163(1): 145 - 147. [Abstract] [Full Text] [PDF]

				E. L. Moses-Kolko, D. Bogen, J. Perel, A. Bregar, K. Uhl, B. Levin, and K. L. Wisner Neonatal Signs After Late In Utero Exposure to Serotonin Reuptake Inhibitors: Literature Review and Implications for Clinical Applications JAMA, May 18, 2005; 293(19): 2372 - 2383. [Abstract] [Full Text] [PDF]

				P. Vanhaesebrouck, F. De Bock, A. Zecic, C. De Praeter, K. Smets, K. De Coen, and L. Goossens Phototherapy-Mediated Syndrome of Inappropriate Secretion of Antidiuretic Hormone in an In Utero Selective Serotonin Reuptake Inhibitor-Exposed Newborn Infant Pediatrics, May 1, 2005; 115(5): e508 - e511. [Abstract] [Full Text] [PDF]

				G. Fricchione Generalized Anxiety Disorder N. Engl. J. Med., August 12, 2004; 351(7): 675 - 682. [Full Text] [PDF]

				P. S. Zeskind and L. E. Stephens Maternal Selective Serotonin Reuptake Inhibitor Use During Pregnancy and Newborn Neurobehavior Pediatrics, February 1, 2004; 113(2): 368 - 375. [Abstract] [Full Text] [PDF]

				Antidepressants During Pregnancy: Fetuses Get Less Journal Watch Women's Health, July 9, 2003; 2003(709): 3 - 3. [Full Text]

				J. Rosack Psychiatr News, May 16, 2003; 38(10): 46 - 47. [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 2003 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us