Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Kim, J.-J. Articles by Lee, M. C. Search for Related Content PubMed Citation Articles by Kim, J.-J. Articles by Lee, M. C. Neuropsychology Schizophrenia Spectrum Disorders PET

Functional Disconnection Between the Prefrontal and Parietal Cortices During Working Memory Processing in Schizophrenia: A [¹⁵O]H₂O PET Study

OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. METHOD: [¹⁵O]H₂O positron emission tomography was used to compare regional blood flow changes in 12 schizophrenic and 12 healthy comparison subjects during the n-back sequential-picture working memory task. Interregional correlation was assessed by correlating the regional activation of the lateral prefrontal area with that of other activated areas in each subject group. RESULTS: Dorsolateral prefrontal activation was observed around the right superior frontal sulcus in the healthy subjects, and ventrolateral prefrontal activation below the right inferior frontal sulcus was observed in the schizophrenic patients. Activation in the right lateral prefrontal cortex was significantly correlated with activation in the bilateral inferior parietal region in the healthy subjects but was not correlated with any regional activation in the patients. CONCLUSIONS: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia.

This article has been cited by other articles:

				Y. Liu, M. Liang, Y. Zhou, Y. He, Y. Hao, M. Song, C. Yu, H. Liu, Z. Liu, and T. Jiang Disrupted small-world networks in schizophrenia Brain, April 1, 2008; 131(4): 945 - 961. [Abstract] [Full Text] [PDF]

				H.-Y. Tan, J. H. Callicott, and D. R. Weinberger Dysfunctional and Compensatory Prefrontal Cortical Systems, Genes and the Pathogenesis of Schizophrenia Cereb Cortex, September 1, 2007; 17(suppl_1): i171 - i181. [Abstract] [Full Text] [PDF]

				D. M. Barch and J. G. Csernansky Abnormal Parietal Cortex Activation During Working Memory in Schizophrenia: Verbal Phonological Coding Disturbances Versus Domain-General Executive Dysfunction Am J Psychiatry, July 1, 2007; 164(7): 1090 - 1098. [Abstract] [Full Text] [PDF]

				H.-Y. Tan, S. Sust, J. W. Buckholtz, V. S. Mattay, A. Meyer-Lindenberg, M. F. Egan, D. R. Weinberger, and J. H. Callicott Dysfunctional Prefrontal Regional Specialization and Compensation in Schizophrenia Am J Psychiatry, November 1, 2006; 163(11): 1969 - 1977. [Abstract] [Full Text] [PDF]

				H. C. Whalley, E. Simonotto, I. Marshall, D. G. C. Owens, N. H. Goddard, E. C. Johnstone, and S. M. Lawrie Functional disconnectivity in subjects at high genetic risk of schizophrenia Brain, September 1, 2005; 128(9): 2097 - 2108. [Abstract] [Full Text] [PDF]

				M. Sarter, C. L Nelson, and J. P Bruno Cortical Cholinergic Transmission and Cortical Information Processing in Schizophrenia Schizophr Bull, January 1, 2005; 31(1): 117 - 138. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2003 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us