Am J Psychiatry 160:350-355, February 2003
© 2003 American Psychiatric Association
Fatigue in Obstructive Sleep Apnea: Driven by Depressive Symptoms Instead of Apnea Severity?
Wayne A. Bardwell, Ph.D.,
Polly Moore, Ph.D.,
Sonia Ancoli-Israel, Ph.D., and
Joel E. Dimsdale, M.D.
OBJECTIVE: Obstructive sleep apnea is a common and frequently devastating illness that often includes significant fatigue. Fatigue is also a hallmark depressive symptom. The authors wondered if depressive symptoms in patients with obstructive sleep apnea would account for some of the fatigue beyond that explained by obstructive sleep apnea severity. METHOD: Sixty patients with obstructive sleep apnea—i.e., score  15 on the respiratory disturbance index (mean score=49; range=15–111)—underwent polysomnography and completed the Center for Epidemiological Studies Depression Scale (CES-D Scale), Profile of Mood States (POMS), and Medical Outcomes Study surveys. Data were analyzed by using hierarchical regression, with POMS fatigue score as the dependent variable (step 1, forced entry of apnea severity variables; step 2, forced entry of CES-D Scale score). RESULTS: Whereas score on the respiratory disturbance index and the percent of time oxygen saturation was <90% together accounted for 4.2% of variance in scores on the POMS fatigue scale, the CES-D Scale score accounted for 10 times the variance (i.e., an additional 42.3%) in POMS fatigue scale score. CONCLUSIONS: After obstructive sleep apnea severity was controlled, higher levels of depressive symptoms were dramatically and independently associated with greater levels of fatigue. Assessment and treatment of mood symptoms—not just treatment of the disordered breathing itself—might reduce the fatigue experienced by patients with obstructive sleep apnea.
This article has been cited by other articles:
|
|
|
|
 
R. Nelesen, Y. Dar, K. Thomas, and J. E. Dimsdale
The Relationship Between Fatigue and Cardiac Functioning
Arch Intern Med,
May 12, 2008;
168(9):
943 - 949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Lim, K. S. Thomas, W. A. Bardwell, and J. E. Dimsdale
Which Measures of Obesity Are Related to Depressive Symptoms and in Whom?
Psychosomatics,
February 1, 2008;
49(1):
23 - 28.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Buyse and the participants of working group 2
Treatment effects of sleep apnoea: where are we now?
Eur. Respir. Rev.,
December 1, 2007;
16(106):
146 - 168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. A. Bardwell, L. Natarajan, J. E. Dimsdale, C. L. Rock, J. E. Mortimer, K. Hollenbach, and J. P. Pierce
Objective Cancer-Related Variables Are Not Associated With Depressive Symptoms in Women Treated for Early-Stage Breast Cancer
J. Clin. Oncol.,
June 1, 2006;
24(16):
2420 - 2427.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Schwartz, W. C. Kohler, and G. Karatinos
Symptoms of Depression in Individuals With Obstructive Sleep Apnea May Be Amenable to Treatment With Continuous Positive Airway Pressure
Chest,
September 1, 2005;
128(3):
1304 - 1309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Lim, S. Hong, R. Nelesen, and J. E. Dimsdale
The Association of Obesity, Cytokine Levels, and Depressive Symptoms With Diverse Measures of Fatigue in Healthy Subjects
Arch Intern Med,
April 25, 2005;
165(8):
910 - 915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Wells, R. C. Day, R. M. Carney, K. E. Freedland, and S. P. Duntley
Depression Predicts Self-reported Sleep Quality in Patients With Obstructive Sleep Apnea
Psychosom Med,
September 1, 2004;
66(5):
692 - 697.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 2003
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
