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Reduction of Symptoms by Valacyclovir in Cytomegalovirus-Seropositive Individuals With Schizophrenia

OBJECTIVE: The study was an investigation of the effect of the antiviral medication valacyclovir on the symptoms of outpatients with persistent schizophrenia. METHOD: Oral valacyclovir, 1 g twice daily, was administered to 65 outpatients over 16 weeks along with their usual psychiatric medications. Changes in psychiatric symptoms were measured with the Positive and Negative Syndrome Scale and were tested for correlations with antibodies to potentially neurotropic human herpesviruses, as measured by immunoassay before the start of the therapy. RESULTS: There was a significant improvement in the psychiatric symptoms of individuals who were seropositive for cytomegalovirus. Improvement was not associated with antibodies to other herpesviruses or to a range of demographic and clinical variables. CONCLUSIONS: The replication of cytomegalovirus may contribute to the symptoms of schizophrenia in some individuals.

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				C.J. Carter Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondii Schizophr Bull, June 13, 2008; (2008) sbn054v1. [Abstract] [Full Text] [PDF]

				F. Dickerson, J. Boronow, C. Stallings, A. Origoni, and R. Yolken Toxoplasma gondii in Individuals With Schizophrenia: Association With Clinical and Demographic Factors and With Mortality Schizophr Bull, May 1, 2007; 33(3): 737 - 740. [Abstract] [Full Text] [PDF]

				F. Dickerson, B. Kirkpatrick, J. Boronow, C. Stallings, A. Origoni, and R. Yolken Deficit Schizophrenia: Association With Serum Antibodies to Cytomegalovirus Schizophr Bull, April 1, 2006; 32(2): 396 - 400. [Abstract] [Full Text] [PDF]

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