Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Kalayam, B. Articles by Alexopoulos, G. S. Search for Related Content PubMed Citation Articles by Kalayam, B. Articles by Alexopoulos, G. S. Neurophysiology Geriatric Psychiatry Depression

A Preliminary Study of Left Frontal Region Error Negativity and Symptom Improvement in Geriatric Depression

OBJECTIVE: This study tested the hypothesis that frontal error negative wave amplitude on EEG during Stroop test activation predict change in depressive symptoms in depressed elders. METHOD: Twenty-two older patients with major depression received controlled treatment with citalopram at a target dose of 40 mg/day for 6 weeks. Paramedian error negative waves were recorded during Stroop activation before treatment. RESULTS: Nine subjects who remained symptomatic had larger left frontal error negative waves than the subjects who achieved remission. Left frontal error negative waves were correlated with percent change of depressive symptoms from baseline. Other paramedian error negative waves did not distinguish remitted from unremitted subjects. Left frontal error negative waves were negatively correlated with Mattis Dementia Rating Scale scores for initiation/perseveration; these scores were lower in unremitted than remitted patients. CONCLUSIONS: Increased left frontal error negative waves are associated with limited or slow change in depressive symptoms in elders receiving citalopram.

This article has been cited by other articles:

				A. J. Holmes and D. A. Pizzagalli Spatiotemporal Dynamics of Error Processing Dysfunctions in Major Depressive Disorder Arch Gen Psychiatry, February 1, 2008; 65(2): 179 - 188. [Abstract] [Full Text] [PDF]

				P. H. Chiu and P. J. Deldin Neural Evidence for Enhanced Error Detection in Major Depressive Disorder Am J Psychiatry, April 1, 2007; 164(4): 608 - 616. [Abstract] [Full Text] [PDF]

				S. F. Taylor, E. R. Stern, and W. J. Gehring Neural Systems for Error Monitoring: Recent Findings and Theoretical Perspectives Neuroscientist, April 1, 2007; 13(2): 160 - 172. [Abstract] [PDF]

				J. Mohlman Does Executive Dysfunction Affect Treatment Outcome in Late-Life Mood and Anxiety Disorders? J Geriatr Psychiatry Neurol, June 1, 2005; 18(2): 97 - 108. [Abstract] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2003 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us