Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Peters, J. M. Articles by Frölich, L. Search for Related Content PubMed Citation Articles by Peters, J. M. Articles by Frölich, L. Neurophysiology Geriatric Psychiatry Alzheimer's Disease Cognition

Olfactory Function in Mild Cognitive Impairment and Alzheimer’s Disease: An Investigation Using Psychophysical and Electrophysiological Techniques

OBJECTIVE: To clarify the olfactory deficit hypothesis regarding Alzheimer’s disease, the authors compared olfactory function in patients with Alzheimer’s disease, subjects with mild cognitive impairment, and healthy comparison subjects. METHOD: Olfactory function of 14 patients with mild Alzheimer’s disease, eight subjects with mild cognitive impairment, and eight healthy age-matched comparison subjects was assessed with both psychophysical tests and olfactory event-related potentials. RESULTS: Group comparison of the psychophysical test results showed a significant main effect of diagnosis for odor detection threshold, odor discrimination, and odor identification. These results correlated only partially with those obtained from olfactory event-related potentials. Seven Alzheimer’s disease patients and four with mild cognitive impairment showed no olfactory event-related potentials, suggesting hyposmia, while all comparison subjects had clearly discernible responses. Patients with Alzheimer’s disease were significantly more likely to be nonresponders. In the four Alzheimer’s disease patients and four subjects with mild cognitive impairment who had clear electrophysiological responses, amplitudes and latencies of the various event-related potential components were normal, i.e., similar to those of the comparison subjects, although 12 of the 14 Alzheimer’s disease patients and seven of the eight mildly impaired subjects were classified as functionally anosmic with psychophysical methods. CONCLUSIONS: The electrophysiological results confirm prior findings of olfactory dysfunction in patients with Alzheimer’s disease and preclinical Alzheimer’s disease. Investigations of larger study groups with detailed cognitive examination and postmortem diagnosis may resolve the intriguing possibility of early diagnosis and discrimination of Alzheimer’s disease subtypes through chemosensory event-related potentials in addition to existing biomarkers.

This article has been cited by other articles:

				K. Markovic, U. Reulbach, A. Vassiliadu, J. Lunkenheimer, B. Lunkenheimer, R. Spannenberger, and N. Thuerauf Good News for Elderly Persons: Olfactory Pleasure Increases at Later Stages of the Life Span J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2007; 62(11): 1287 - 1293. [Abstract] [Full Text] [PDF]

				J M Boyce and G R Shone Effects of ageing on smell and taste. Postgrad. Med. J., April 1, 2006; 82(966): 239 - 241. [Abstract] [Full Text] [PDF]

				J. K. Olofsson and S. Nordin Gender Differences in Chemosensory Perception and Event-related Potentials Chem Senses, September 1, 2004; 29(7): 629 - 637. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2003 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us