Am J Psychiatry 160:178-180, January 2003
© 2003 American Psychiatric Association
Validity of the Mood Disorder Questionnaire: A General Population Study
Robert M.A. Hirschfeld, M.D.,
Charles Holzer, Ph.D.,
Joseph R. Calabrese, M.D.,
Myrna Weissman, Ph.D.,
Michael Reed, Ph.D.,
Marilyn Davies, Ph.D.,
Mark A. Frye, M.D.,
Paul Keck, M.D.,
Susan McElroy, M.D.,
Lydia Lewis, B.A.,
Jonathan Tierce, C.Phil.,
Karen D. Wagner, M.D., Ph.D., and
Elizabeth Hazard, Ph.D.
OBJECTIVE: This study tested the validity in the adult general population of the Mood Disorder Questionnaire, a screening instrument for bipolar I and II disorders. The Mood Disorder Questionnaire has been validated in a psychiatric outpatient study group. METHOD: A total of 711 subjects (stratified by Mood Disorder Questionnaire score) were randomly selected from a group of 85,358 adult respondents in a nationwide epidemiological general population sample that was balanced for key demographic variables. Of these, 695 subjects received a telephone interview involving an abbreviated version of the Structured Clinical Interview for DSM-IV. RESULTS: A sensitivity of 0.281 and a specificity of 0.972 were obtained for the Mood Disorder Questionnaire. CONCLUSIONS: The Mood Disorder Questionnaire is a useful screening instrument for bipolar I and II disorders in the community. The operating characteristics of the Mood Disorder Questionnaire in the general population differ substantially from its characteristics in outpatient psychiatric settings.
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