Temporal Lobe Abnormalities in First-Episode Psychosis

doi:10.1176/appi.ajp.159.7.1232



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	Neurophysiology
	Schizophrenia Spectrum Disorders
	MRI

Am J Psychiatry 159:1232-1235, July 2002
© 2002 American Psychiatric Association

Brief Report

Temporal Lobe Abnormalities in First-Episode Psychosis

Alex Sumich, M.A., Xavier A. Chitnis, M.Sc., Dominic G. Fannon, M.R.C.Psych., Séamus O’Ceallaigh, M.R.C.Psych., Victor C. Doku, M.R.C.Psych., Abi Falrowicz, B.Sc., Nicolette Marshall, M.Sc., Vallakalil M. Matthew, M.B., B.S., M.R.C.Psych., Mark Potter, M.R.C.Psych., and Tonmoy Sharma, M.Sc., M.R.C.Psych.

OBJECTIVE: The nature and time course of temporal lobe abnormalitiesin psychotic illness remain controversial. Confounds includedisease chronicity, gender, and handedness. The present studyinvestigated temporal substructures in right-handed male patientsexperiencing their first episode of psychotic illness. METHOD:Magnetic resonance imaging scans were obtained for 25 minimallytreated patients experiencing their first psychotic episodeand 16 healthy comparison subjects. Group differences in volumesof the hippocampus, amygdala, planum temporale, and Heschl’sgyrus were tested. RESULTS: The patients had smaller bilateralhippocampal and left planum temporale volumes than the comparisonsubjects. Paranoid and nonparanoid patients differed in leftamygdala volume. CONCLUSIONS: The authors conclude that bilateralhippocampal and left planum temporale abnormalities are presentnear the onset of psychosis.

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