Am J Psychiatry 159:1080-1092, July 2002
© 2002 American Psychiatric Association
Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review
Mary Cannon, M.D., Ph.D., M.R.C.Psych.,
Peter B. Jones, M.D., Ph.D., M.R.C. Psych., and
Robin M. Murray, M.D., D.Sc., F.R.C.Psych.
OBJECTIVE: This paper reviews the literature on obstetric complications as a risk factor for schizophrenia. The authors trace the evolution of this literature through different methods and carry out a quantitative review of the results from prospective, population-based studies. METHOD: Relevant papers were identified by a MEDLINE search, by examination of reference lists of published papers, and through personal contact with researchers in the field. Studies were grouped in chronological order according to common themes or methods. Meta-analytic techniques were used to summarize the findings of prospective population-based studies. RESULTS: The meta-analytic synthesis of the prospective population-based studies revealed that three groups of complications were significantly associated with schizophrenia: 1) complications of pregnancy (bleeding, diabetes, rhesus incompatibility, preeclampsia); 2) abnormal fetal growth and development: (low birthweight, congenital malformations, reduced head circumference), and 3) complications of delivery (uterine atony, asphyxia, emergency Cesarean section). Pooled estimates of effect sizes were generally less than 2. CONCLUSIONS: Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness. Lack of statistical power to measure small and interactive effects and lack of detailed information about the prenatal period are major problems with current approaches. A combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations.
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65(10):
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|
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|
|
|
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(2008)
sbn084v1.
[Abstract]
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|
|
|
|
|
|
|
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34(4):
774 - 790.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Hill, M. S. H. Harris, E. S. Herbener, M. Pavuluri, and J. A. Sweeney
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34(4):
743 - 759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. MacCabe
Population-based Cohort Studies on Premorbid Cognitive Function in Schizophrenia
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June 27, 2008;
(2008)
mxn007v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R Zubrick
Maternal affective or substance disorders are risk factors for subsequent pregnancy loss
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February 1, 2008;
11(1):
29 - 29.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Juvonen, A. Reunanen, J. Haukka, M. Muhonen, J. Suvisaari, R. Arajarvi, T. Partonen, and J. Lonnqvist
Incidence of Schizophrenia in a Nationwide Cohort of Patients With Type 1 Diabetes Mellitus
Arch Gen Psychiatry,
August 1, 2007;
64(8):
894 - 899.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Zammit, S. Lewis, D. Gunnell, and G. D. Smith
Schizophrenia and Neural Tube Defects: Comparisons From an Epidemiological Perspective
Schizophr Bull,
July 1, 2007;
33(4):
853 - 858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Dutta, T. Greene, J. Addington, K. McKenzie, M. Phillips, and R. M. Murray
Biological, Life Course, and Cross-Cultural Studies All point Toward the Value of Dimensional and Developmental Ratings in the Classification of Psychosis
Schizophr Bull,
July 1, 2007;
33(4):
868 - 876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Farooqi, B. Hagglof, G. Sedin, L. Gothefors, and F. Serenius
Mental Health and Social Competencies of 10- to 12-Year-Old Children Born at 23 to 25 Weeks of Gestation in the 1990s: A Swedish National Prospective Follow-up Study
Pediatrics,
July 1, 2007;
120(1):
118 - 133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. N. Greenley, H. G. Taylor, D. Drotar, and N. M. Minich
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J. Pediatr. Psychol.,
May 1, 2007;
32(4):
453 - 462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Clarke, M. Cannon, M. W Hogg, M. N. Marks, S. Conroy, S. J. Pawlby, A. Greenough, and K. Nicolaides
Foetal brain development in offspring of women with psychosis
The British Journal of Psychiatry,
May 1, 2007;
190(5):
445 - 446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Ettinger, M. Picchioni, S. Landau, K. Matsumoto, N. E. van Haren, N. Marshall, M.-H. Hall, K. Schulze, T. Toulopoulou, N. Davies, et al.
Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia
Arch Gen Psychiatry,
April 1, 2007;
64(4):
401 - 409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kolevzon, R. Gross, and A. Reichenberg
Prenatal and Perinatal Risk Factors for Autism: A Review and Integration of Findings
Arch Pediatr Adolesc Med,
April 1, 2007;
161(4):
326 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Alati, D. A. Lawlor, A. A. Mamun, G. M. Williams, J. M. Najman, M. O'Callaghan, and W. Bor
Is There a Fetal Origin of Depression? Evidence from the Mater University Study of Pregnancy and Its Outcomes
Am. J. Epidemiol.,
March 1, 2007;
165(5):
575 - 582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. McGrath
The Surprisingly Rich Contours of Schizophrenia Epidemiology
Arch Gen Psychiatry,
January 1, 2007;
64(1):
14 - 16.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Brown, T. Bottiglieri, C. A. Schaefer, C. P. Quesenberry Jr, L. Liu, M. Bresnahan, and E. S. Susser
Elevated Prenatal Homocysteine Levels as a Risk Factor for Schizophrenia
Arch Gen Psychiatry,
January 1, 2007;
64(1):
31 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. T. Webb, K. M. Abel, A. R. Pickles, L. Appleby, S. A. King-Hele, and P. B. Mortensen
Mortality Risk Among Offspring of Psychiatric Inpatients: A Population-Based Follow-Up to Early Adulthood
Am J Psychiatry,
December 1, 2006;
163(12):
2170 - 2177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Rasmussen
Paternal age, size at birth, and size in young adulthood - risk factors for schizophrenia
Eur. J. Endocrinol.,
November 1, 2006;
155(suppl_1):
S65 - S69.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Scott, Y. McNeill, J. Cavanagh, M. Cannon, and R. Murray
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The British Journal of Psychiatry,
July 1, 2006;
189(1):
3 - 11.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Wiles, T. J. Peters, J. Heron, D. Gunnell, A. Emond, G. Lewis, and for the ALSPAC Study Team
Fetal Growth and Childhood Behavioral Problems: Results from the ALSPAC Cohort
Am. J. Epidemiol.,
May 1, 2006;
163(9):
829 - 837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Clarke, M. Harley, and M. Cannon
The Role of Obstetric Events in Schizophrenia
Schizophr Bull,
January 1, 2006;
32(1):
3 - 8.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. K. E. Magnusson, F. Rasmussen, D. A. Lawlor, P. Tynelius, and D. Gunnell
Association of Body Mass Index with Suicide Mortality: A Prospective Cohort Study of More than One Million Men
Am. J. Epidemiol.,
January 1, 2006;
163(1):
1 - 8.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-i. Shukunami, K. Nishijima, M. Shukunami, F. Kotsuji, M. Isohanni, and K. Moilanen
Is gestational week at birth a predictor of schizophrenia? * Authors' reply
The British Journal of Psychiatry,
December 1, 2005;
187(6):
589 - 589.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Alati, J. M. Najman, S. A. Kinner, A. A. Mamun, G. M. Williams, M. O'Callaghan, and W. Bor
Early Predictors of Adult Drinking: A Birth Cohort Study
Am. J. Epidemiol.,
December 1, 2005;
162(11):
1098 - 1107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gunnell and G. Lewis
Studying suicide from the life course perspective: implications for prevention
The British Journal of Psychiatry,
September 1, 2005;
187(3):
206 - 208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. St Clair, M. Xu, P. Wang, Y. Yu, Y. Fang, F. Zhang, X. Zheng, N. Gu, G. Feng, P. Sham, et al.
Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961
JAMA,
August 3, 2005;
294(5):
557 - 562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. ISOHANNI, E. LAURONEN, K. MOILANEN, I. ISOHANNI, L. KEMPPAINEN, H. KOPONEN, J. MIETTUNEN, P. MAKI, S. RASANEN, J. VEIJOLA, et al.
Predictors of schizophrenia: Evidence from the Northern Finland 1966 Birth Cohort and other sources
The British Journal of Psychiatry,
August 1, 2005;
187(48):
s4 - s7.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. WILES, T. J. PETERS, D. A. LEON, and G. LEWIS
Birth weight and psychological distress at age 45-51 years: Results from the Aberdeen Children of the 1950s cohort study
The British Journal of Psychiatry,
July 1, 2005;
187(1):
21 - 28.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Maki, J. Veijola, P. B. Jones, G. K. Murray, H. Koponen, P. Tienari, J. Miettunen, P. Tanskanen, K.-E. Wahlberg, J. Koskinen, et al.
Predictors of schizophrenia--a review
Br. Med. Bull.,
June 9, 2005;
73-74(1):
1 - 15.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Webb, K. Abel, A. Pickles, and L. Appleby
Mortality in Offspring of Parents With Psychotic Disorders: A Critical Review and Meta-Analysis
Am J Psychiatry,
June 1, 2005;
162(6):
1045 - 1056.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kumar and F. Regan
Management of pregnancies with RhD alloimmunisation
BMJ,
May 28, 2005;
330(7502):
1255 - 1258.
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. O'keane and J. Scott
From 'obstetric complications' to a maternal-foetal origin hypothesis of mood disorder
The British Journal of Psychiatry,
May 1, 2005;
186(5):
367 - 368.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A S David and M Prince
Psychosis following head injury: a critical review
J. Neurol. Neurosurg. Psychiatry,
March 1, 2005;
76(suppl_1):
i53 - i60.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Cantor-Graae and J.-P. Selten
Schizophrenia and Migration: A Meta-Analysis and Review
Am J Psychiatry,
January 1, 2005;
162(1):
12 - 24.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. V. Jablensky, V. Morgan, S. R. Zubrick, C. Bower, and L.-A. Yellachich
Pregnancy, Delivery, and Neonatal Complications in a Population Cohort of Women With Schizophrenia and Major Affective Disorders
Am J Psychiatry,
January 1, 2005;
162(1):
79 - 91.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hack, E. A. Youngstrom, L. Cartar, M. Schluchter, H. G. Taylor, D. Flannery, N. Klein, and E. Borawski
Behavioral Outcomes and Evidence of Psychopathology Among Very Low Birth Weight Infants at Age 20 Years
Pediatrics,
October 1, 2004;
114(4):
932 - 940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Brown, M. D. Begg, S. Gravenstein, C. A. Schaefer, R. J. Wyatt, M. Bresnahan, V. P. Babulas, and E. S. Susser
Serologic Evidence of Prenatal Influenza in the Etiology of Schizophrenia
Arch Gen Psychiatry,
August 1, 2004;
61(8):
774 - 780.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. F. Sullivan, K. S. Kendler, and M. C. Neale
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Arch Gen Psychiatry,
December 1, 2003;
60(12):
1187 - 1192.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gunnell, F. Rasmussen, D. Fouskakis, P. Tynelius, and G. Harrison
Patterns of Fetal and Childhood Growth and the Development of Psychosis in Young Males: A Cohort Study
Am. J. Epidemiol.,
August 15, 2003;
158(4):
291 - 300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. McGrath
Invited Commentary: Gaining Traction on the Epidemiologic Landscape of Schizophrenia
Am. J. Epidemiol.,
August 15, 2003;
158(4):
301 - 304.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. PRETI
Fetal Hypoxia, Genetic Risk, and Schizophrenia
Am J Psychiatry,
June 1, 2003;
160(6):
1186 - 1186.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.J. CROW
Obstetric Complications and Schizophrenia
Am J Psychiatry,
May 1, 2003;
160(5):
1011 - 1012.
[Full Text]
|
|
|
|
|
|
|
S. Miyamoto, A. S. LaMantia, G. E. Duncan, P. Sullivan, J. H. Gilmore, and J. A. Lieberman
Recent Advances in the Neurobiology of Schizophrenia
Mol. Interv.,
February 1, 2003;
3(1):
27 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
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