Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Strakowski, S. M. Articles by Adler, C. M. Search for Related Content PubMed Citation Articles by Strakowski, S. M. Articles by Adler, C. M. Bipolar Disorder MRI

Ventricular and Periventricular Structural Volumes in First- Versus Multiple-Episode Bipolar Disorder

OBJECTIVE: Ventriculomegaly has been reported in bipolar disorder, although whether it occurs at illness onset or progresses during the course of the disorder is unknown. In addition, it is unknown whether ventriculomegaly in bipolar disorder reflects acquired volume loss or underdevelopment of periventricular structures. METHOD: Magnetic resonance imaging was used to measure the volumes of the lateral and third ventricles and periventricular structures (caudate, putamen, thalamus, hippocampus). Patients with DSM-IV bipolar disorder, 18 who were having a first episode and 17 with multiple episodes, were compared with 32 healthy subjects. RESULTS: The lateral ventricles were significantly larger in the patients with multiple-episode bipolar disorder than in the first-episode patients or the healthy subjects, even after periventricular and total cerebral volumes were taken into account. Having larger lateral ventricles was associated with a higher number of prior manic episodes. The multiple-episode patients had a smaller total cerebral volume than the healthy subjects but not the first-episode patients. The putamen was significantly larger in the first-episode patients (and nearly so in the multiple-episode patients) than in the healthy subjects, although there was no difference between patient groups. CONCLUSIONS: Lateral ventriculomegaly was greater in bipolar disorder patients who had had repeated manic episodes, but it does not appear to be secondary to small critical periventricular structures. A larger than normal striatum, which has been reported in previous studies, was observed in first-episode patients. These results support the importance of prospectively studying neuroanatomic changes in bipolar disorder.

This article has been cited by other articles:

				M. J. Kempton, J. R. Geddes, U. Ettinger, S. C. R. Williams, and P. M. Grasby Meta-analysis, Database, and Meta-regression of 98 Structural Imaging Studies in Bipolar Disorder Arch Gen Psychiatry, September 1, 2008; 65(9): 1017 - 1032. [Abstract] [Full Text] [PDF]

				J. Hwang, I. K. Lyoo, S. R. Dager, S. D. Friedman, J. S. Oh, J. Y. Lee, S. J. Kim, D. L. Dunner, and P. F. Renshaw Basal Ganglia Shape Alterations in Bipolar Disorder Am J Psychiatry, February 1, 2006; 163(2): 276 - 285. [Abstract] [Full Text] [PDF]

				S. M. Strakowski, C. M. Adler, S. K. Holland, N. P. Mills, M. P. DelBello, and J. C. Eliassen Abnormal fMRI Brain Activation in Euthymic Bipolar Disorder Patients During a Counting Stroop Interference Task Am J Psychiatry, September 1, 2005; 162(9): 1697 - 1705. [Abstract] [Full Text] [PDF]

				N. P. Mills, M. P. DelBello, C. M. Adler, and S. M. Strakowski MRI Analysis of Cerebellar Vermal Abnormalities in Bipolar Disorder Am J Psychiatry, August 1, 2005; 162(8): 1530 - 1533. [Abstract] [Full Text] [PDF]

				C. McDonald, E. T. Bullmore, P. C. Sham, X. Chitnis, H. Wickham, E. Bramon, and R. M. Murray Association of Genetic Risks for Schizophrenia and Bipolar Disorder With Specific and Generic Brain Structural Endophenotypes Arch Gen Psychiatry, October 1, 2004; 61(10): 974 - 984. [Abstract] [Full Text] [PDF]

				K. Kasai, M. E. Shenton, D. F. Salisbury, T. Onitsuka, S. K. Toner, D. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, and R. W. McCarley Differences and Similarities in Insular and Temporal Pole MRI Gray Matter Volume Abnormalities in First-Episode Schizophrenia and Affective Psychosis Arch Gen Psychiatry, November 1, 2003; 60(11): 1069 - 1077. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2002 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us