Am J Psychiatry 159:1783-1785, October 2002
© 2002 American Psychiatric Association
No Association Between Obsessive-Compulsive Disorder and the 5-HT1Dß Receptor Gene
Daniela Di Bella, M.D., Ph.D.,
Maria Cristina Cavallini, M.D., and
Laura Bellodi, M.D.
OBJECTIVE: Serotonin abnormalities may be involved in the etiopathogenesis of obsessive-compulsive disorder (OCD). The silent G-to-C substitution at nucleotide 861 of the coding region of the 5-HT1Dß receptor gene may be associated with liability to OCD. The aim of this study was to investigate this association in an Italian OCD study group. METHOD: Genotyping for 5-HT1Dß was performed for 79 nuclear families of probands with OCD. The transmission/disequilibrium test was used to determine transmission of the alleles from parents to offspring. RESULTS: Of the 79 families, 48 were informative for the analysis, i.e., both parents were genotyped for 5-HT1Dß, and at least one parent was heterozygous. No preferential transmission of either allele of the 5-HT1Dß gene was observed. CONCLUSIONS: These data do not support a role for the 5-HT1Dß receptor gene in conferring susceptibility to OCD.
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J. J. Hudziak, C. E. M. van Beijsterveldt, R. R. Althoff, C. Stanger, D. C. Rettew, E. C. Nelson, R. D. Todd, M. Bartels, and D. I. Boomsma
Genetic and Environmental Contributions to the Child Behavior Checklist Obsessive-Compulsive Scale: A Cross-cultural Twin Study
Arch Gen Psychiatry,
June 1, 2004;
61(6):
608 - 616.
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