The American Journal of Psychiatry
Journal Home Search Current Issue Past Issues Subscribe All APPI Journals Help Contact Us
 
Quicksearch
Advanced Search
Or Search All APPI Journals
This Article
* Full Text
* Full Text (PDF)
* Alert me when this article is cited
* Alert me if a correction is posted
* Citation Map
Services
* Email this article to a Colleague
* Similar articles in this journal
* Similar articles in PubMed
* Alert me to new issues of the journal
* Add to My Articles & Searches
* Download to citation manager
* reprints & permissions
Citing Articles
* Citing Articles via HighWire
* Citing Articles via Google Scholar
Google Scholar
* Articles by Carter, C. S.
* Articles by Stenger, V. A.
* Search for Related Content
PubMed
* PubMed Citation
* Articles by Carter, C. S.
* Articles by Stenger, V. A.
Related Collections
* Neurophysiology
* Schizophrenia Spectrum Disorders
* Other Neuroimaging
Am J Psychiatry 158:1423-1428, September 2001
© 2001 American Psychiatric Association

Article

Anterior Cingulate Cortex Activity and Impaired Self-Monitoring of Performance in Patients With Schizophrenia: An Event-Related fMRI Study

Cameron S. Carter, M.D., Angus W. MacDonald, III, M.S., Laura L. Ross, B.A., and V. Andrew Stenger, Ph.D.

OBJECTIVE: The authors examined brain activity associated with the internal monitoring of performance to test the hypothesis that error-related activity in the anterior cingulate cortex is impaired in patients with schizophrenia. METHOD: Seventeen patients with schizophrenia and 16 healthy comparison subjects underwent event-related functional magnetic resonance imaging during a continuous performance task; stimulus degradation was used to increase error rates. RESULTS: Comparison subjects, but not schizophrenic patients, showed error-related activity in the anterior cingulate cortex, and this difference in brain activity was significantly different across the two groups. Patients also showed less slowing of reaction time after error commission. CONCLUSIONS: Lower error-related activity in the anterior cingulate cortex and less performance adjustment after error commission are consistent with the hypothesis that disturbances in anterior cingulate cortex function are related to a specific alteration in an evaluative component of executive functioning—the internal monitoring of performance.




This article has been cited by other articles:


Home page
 NeurologyHome page
C. E. Krueger, A. C. Bird, M. E. Growdon, J. Y. Jang, B. L. Miller, and J. H. Kramer
Conflict monitoring in early frontotemporal dementia
Neurology, August 4, 2009; 73(5): 349 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
M. J. Minzenberg, A. R. Laird, S. Thelen, C. S. Carter, and D. C. Glahn
Meta-analysis of 41 Functional Neuroimaging Studies of Executive Function in Schizophrenia
Arch Gen Psychiatry, August 1, 2009; 66(8): 811 - 822.
[Abstract] [Full Text] [PDF]

Home page
 Psychiatr. Serv.Home page
G. Aubin, E. Stip, I. Gelinas, C. Rainville, and C. Chapparo
Daily Functioning and Information-Processing Skills Among Persons With Schizophrenia
Psychiatr Serv, June 1, 2009; 60(6): 817 - 822.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
A. L. Goldman, L. Pezawas, V. S. Mattay, B. Fischl, B. A. Verchinski, Q. Chen, D. R. Weinberger, and A. Meyer-Lindenberg
Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of Heritability
Arch Gen Psychiatry, May 1, 2009; 66(5): 467 - 477.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
G. Barbalat, V. Chambon, N. Franck, E. Koechlin, and C. Farrer
Organization of Cognitive Control Within the Lateral Prefrontal Cortex in Schizophrenia
Arch Gen Psychiatry, April 1, 2009; 66(4): 377 - 386.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
R. A. Morey, T. V. Mitchell, S. Inan, J. A. Lieberman, and A. Belger
Neural Correlates of Automatic and Controlled Auditory Processing in Schizophrenia
J Neuropsychiatry Clin Neurosci, November 1, 2008; 20(4): 419 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Vinogradov, T. L. Luks, B. J. Schulman, and G. V. Simpson
Deficit in a Neural Correlate of Reality Monitoring in Schizophrenia Patients
Cereb Cortex, November 1, 2008; 18(11): 2532 - 2539.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
H. Garavan, J. N Kaufman, and R. Hester
Acute effects of cocaine on the neurobiology of cognitive control
Phil Trans R Soc B, October 12, 2008; 363(1507): 3267 - 3276.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
J. M. Gold, J. A. Waltz, K. J. Prentice, S. E. Morris, and E. A. Heerey
Reward Processing in Schizophrenia: A Deficit in the Representation of Value
Schizophr Bull, September 1, 2008; 34(5): 835 - 847.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. N. Thakkar, F. E. Polli, R. M. Joseph, D. S. Tuch, N. Hadjikhani, J. J.S. Barton, and D. S. Manoach
Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD)
Brain, September 1, 2008; 131(9): 2464 - 2478.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
A. B. Hains and A. F.T. Arnsten
Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness
Learn. Mem., August 6, 2008; 15(8): 551 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
R. Hester, N. Barre, K. Murphy, T. J. Silk, and J. B. Mattingley
Human Medial Frontal Cortex Activity Predicts Learning from Errors
Cereb Cortex, August 1, 2008; 18(8): 1933 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J. L. Paxton, D. M. Barch, C. A. Racine, and T. S. Braver
Cognitive Control, Goal Maintenance, and Prefrontal Function in Healthy Aging
Cereb Cortex, May 1, 2008; 18(5): 1010 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
T. Hashimoto, H. H. Bazmi, K. Mirnics, Q. Wu, A. R. Sampson, and D. A. Lewis
Conserved Regional Patterns of GABA-Related Transcript Expression in the Neocortex of Subjects With Schizophrenia
Am J Psychiatry, April 1, 2008; 165(4): 479 - 489.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. E. Polli, J. J. S. Barton, K. N. Thakkar, D. N. Greve, D. C. Goff, S. L. Rauch, and D. S. Manoach
Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia
Brain, April 1, 2008; 131(4): 971 - 986.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. L. Grady, H. Yu, and C. Alain
Age-Related Differences in Brain Activity Underlying Working Memory for Spatial and Nonspatial Auditory Information
Cereb Cortex, January 1, 2008; 18(1): 189 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Soc Cogn Affect NeurosciHome page
M. L. Keightley, K. S. Chiew, G. Winocur, and C. L. Grady
Age-related differences in brain activity underlying identification of emotional expressions in faces
Soc Cogn Affect Neurosci, December 1, 2007; 2(4): 292 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
D. M. Barch and J. G. Csernansky
Abnormal Parietal Cortex Activation During Working Memory in Schizophrenia: Verbal Phonological Coding Disturbances Versus Domain-General Executive Dysfunction
Am J Psychiatry, July 1, 2007; 164(7): 1090 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
P. ALLEN, E. AMARO, C. H. Y. FU, S. C. R. WILLIAMS, M. J. BRAMMER, L. C. JOHNS, and P. K. McGUIRE
Neural correlates of the misattribution of speech in schizophrenia
The British Journal of Psychiatry, February 1, 2007; 190(2): 162 - 169.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
B. E. Snitz, A. MacDonald III, J. D. Cohen, R. Y. Cho, T. Becker, and C. S. Carter
Lateral and Medial Hypofrontality in First-Episode Schizophrenia: Functional Activity in a Medication-Naive State and Effects of Short-Term Atypical Antipsychotic Treatment
Am J Psychiatry, December 1, 2005; 162(12): 2322 - 2329.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
G. D. Honey, E. Pomarol-Clotet, P. R. Corlett, R. A. E. Honey, P. J. Mckenna, E. T. Bullmore, and P. C. Fletcher
Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
Brain, November 1, 2005; 128(11): 2597 - 2611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. G. Kerns, J. D. Cohen, A. W. MacDonald III, M. K. Johnson, V. A. Stenger, H. Aizenstein, and C. S. Carter
Decreased Conflict- and Error-Related Activity in the Anterior Cingulate Cortex in Subjects With Schizophrenia
Am J Psychiatry, October 1, 2005; 162(10): 1833 - 1839.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
H.-Y. Tan, W.-C. Choo, C. S.L. Fones, and M. W.L. Chee
fMRI Study of Maintenance and Manipulation Processes Within Working Memory in First-Episode Schizophrenia
Am J Psychiatry, October 1, 2005; 162(10): 1849 - 1858.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. Kopelman, N. C. Andreasen, and P. Nopoulos
Morphology of the Anterior Cingulate Gyrus in Patients With Schizophrenia: Relationship to Typical Neuroleptic Exposure
Am J Psychiatry, October 1, 2005; 162(10): 1872 - 1878.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
D. M Barch
The Relationships Among Cognition, Motivation, and Emotion in Schizophrenia: How Much and How Little We Know
Schizophr Bull, October 1, 2005; 31(4): 875 - 881.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
C. H.Y. Fu, J. Suckling, S. C.R. Williams, C. M. Andrew, G. N. Vythelingum, and P. K. McGuire
Effects of Psychotic State and Task Demand on Prefrontal Function in Schizophrenia: An fMRI Study of Overt Verbal Fluency
Am J Psychiatry, March 1, 2005; 162(3): 485 - 494.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
R. A. Morey, S. Inan, T. V. Mitchell, D. O. Perkins, J. A. Lieberman, and A. Belger
Imaging Frontostriatal Function in Ultra-High-Risk, Early, and Chronic Schizophrenia During Executive Processing
Arch Gen Psychiatry, March 1, 2005; 62(3): 254 - 262.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
R. Hester, C. Fassbender, and H. Garavan
Individual Differences in Error Processing: A Review and Reanalysis of Three Event-related fMRI Studies Using the GO/NOGO Task
Cereb Cortex, September 1, 2004; 14(9): 986 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
T.-U. W. Woo, J. P. Walsh, and F. M. Benes
Density of Glutamic Acid Decarboxylase 67 Messenger RNA-Containing Neurons That Express the N-Methyl-D-Aspartate Receptor Subunit NR2A in the Anterior Cingulate Cortex in Schizophrenia and Bipolar Disorder
Arch Gen Psychiatry, July 1, 2004; 61(7): 649 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
S. Heckers, A. P. Weiss, T. Deckersbach, D. C. Goff, R. J. Morecraft, and G. Bush
Anterior Cingulate Cortex Activation During Cognitive Interference in Schizophrenia
Am J Psychiatry, April 1, 2004; 161(4): 707 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
J. M. Ford, M. Gray, S. L. Whitfield, A. U. Turken, G. Glover, W. O. Faustman, and D. H. Mathalon
Acquiring and Inhibiting Prepotent Responses in Schizophrenia: Event-Related Brain Potentials and Functional Magnetic Resonance Imaging
Arch Gen Psychiatry, February 1, 2004; 61(2): 119 - 129.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Dehaene, E. Artiges, L. Naccache, C. Martelli, A. Viard, F. Schurhoff, C. Recasens, M. L. P. Martinot, M. Leboyer, and J.-L. Martinot
Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: The role of the anterior cingulate
PNAS, November 11, 2003; 100(23): 13722 - 13727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. U. Turken, P. Vuilleumier, D. H. Mathalon, D. Swick, and J. M. Ford
Are Impairments of Action Monitoring and Executive Control True Dissociative Dysfunctions in Patients With Schizophrenia?
Am J Psychiatry, October 1, 2003; 160(10): 1881 - 1883.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. R. Laurens, E. T. C. Ngan, A. T. Bates, K. A. Kiehl, and P. F. Liddle
Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia
Brain, March 1, 2003; 126(3): 610 - 622.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
S. Miyamoto, A. S. LaMantia, G. E. Duncan, P. Sullivan, J. H. Gilmore, and J. A. Lieberman
Recent Advances in the Neurobiology of Schizophrenia
Mol. Interv., February 1, 2003; 3(1): 27 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. Alain, H. E. McNeely, Y. He, B. K. Christensen, and R. West
Neurophysiological Evidence of Error-monitoring Deficits in Patients with Schizophrenia
Cereb Cortex, August 1, 2002; 12(8): 840 - 846.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G D Honey, P C Fletcher, and E T Bullmore
Functional brain mapping of psychopathology
J. Neurol. Neurosurg. Psychiatry, April 1, 2002; 72(4): 432 - 439.
[Abstract] [Full Text] [PDF]

Home page
 JWatch PsychiatryHome page
Impaired Self-Monitoring in Schizophrenia: An Anterior Cingulate Connection?
Journal Watch Psychiatry, October 18, 2001; 2001(1018): 8 - 8.
[Full Text]


Get information about faster international access.

Privacy Policy

Copyright © 2001 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us

American Psychiatric Publishing, Inc. American Psychiatric Association
1000 Wilson Boulevard, Suite 1825, Arlington, VA 22209-3901 * 800-368-5777 * appi at psych.org