Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Tauscher, J. Articles by Kapur, S. Search for Related Content PubMed Citation Articles by Tauscher, J. Articles by Kapur, S. Neurophysiology Miscellaneous Childhood Disorders PET

Inverse Relationship Between Serotonin 5-HT_1A Receptor Binding and Anxiety: A [¹¹C]WAY-100635 PET Investigation in Healthy Volunteers

OBJECTIVE: The authors investigated the relationship between anxiety—a facet of the Revised NEO Personality Inventory dimension of neuroticism—and serotonin 5-HT_1A receptor binding potential. METHOD: Positron emission tomography with [¹¹C]WAY-100635 was used to estimate regional 5-HT_1A binding potential in 19 healthy volunteers who completed the Revised NEO Personality Inventory. Correlation coefficients were calculated to determine the degree of association between 5-HT_1A binding potential and personality inventory measures. RESULTS: There was a significant negative correlation between 5-HT_1A binding potential and anxiety in four regions: the dorsolateral prefrontal cortex, anterior cingulate cortex, parietal cortex, and occipital cortex. CONCLUSIONS: The inverse relationship between 5-HT_1A receptor binding potential and anxiety is consistent with 1) animal models that have shown higher anxiety in mice lacking 5-HT_1A receptors and 2) clinical trial data that have demonstrated antianxiety properties of partial 5-HT_1A agonists.

This article has been cited by other articles:

				N. M. Goodfellow, M. Benekareddy, V. A. Vaidya, and E. K. Lambe Layer II/III of the Prefrontal Cortex: Inhibition by the Serotonin 5-HT1A Receptor in Development and Stress J. Neurosci., August 12, 2009; 29(32): 10094 - 10103. [Abstract] [Full Text] [PDF]

				W.-D. Heiss and K. Herholz Brain Receptor Imaging J. Nucl. Med., February 1, 2006; 47(2): 302 - 312. [Abstract] [Full Text] [PDF]

				U. F. Bailer, G. K. Frank, S. E. Henry, J. C. Price, C. C. Meltzer, L. Weissfeld, C. A. Mathis, W. C. Drevets, A. Wagner, J. Hoge, et al. Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635 Arch Gen Psychiatry, September 1, 2005; 62(9): 1032 - 1041. [Abstract] [Full Text] [PDF]

				R. V. Parsey, M.-J. Belanger, G. M. Sullivan, N. R. Simpson, M. G. Stabin, R. Van Heertum, and J. J. Mann Biodistribution and Radiation Dosimetry of 11C-WAY100,635 in Humans J. Nucl. Med., April 1, 2005; 46(4): 614 - 619. [Abstract] [Full Text] [PDF]

				S. P. David, N. V. Murthy, E. A. Rabiner, M. R. Munafo, E. C. Johnstone, R. Jacob, R. T. Walton, and P. M. Grasby A Functional Genetic Variation of the Serotonin (5-HT) Transporter Affects 5-HT1A Receptor Binding in Humans J. Neurosci., March 9, 2005; 25(10): 2586 - 2590. [Abstract] [Full Text] [PDF]

				O. Bonne, E. Bain, A. Neumeister, A. C. Nugent, M. Vythilingam, R. E. Carson, D. A. Luckenbaugh, W. Eckelman, P. Herscovitch, W. C. Drevets, et al. No Change in Serotonin Type 1A Receptor Binding in Patients With Posttraumatic Stress Disorder Am J Psychiatry, February 1, 2005; 162(2): 383 - 385. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2001 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us