Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Matsumoto, H. Articles by Frangou, S. Search for Related Content PubMed Citation Articles by Matsumoto, H. Articles by Frangou, S. Child/Adolescent Psychiatry Schizophrenia Spectrum Disorders MRI Neurodegeneration

Superior Temporal Gyrus Abnormalities in Early-Onset Schizophrenia: Similarities and Differences With Adult-Onset Schizophrenia

OBJECTIVE: The superior temporal gyrus is associated with developmental mechanisms of brain lateralization and the pathogenesis of language-related schizophrenic symptoms. It therefore lends itself to investigation of developmental deviance in the early onset of schizophrenia. METHOD: Using stereological methods, the authors obtained bilateral measurements of the superior temporal gyrus (total, gray matter, and white matter volumes) from 40 adolescents with recent-onset schizophrenia and an equal number of matched healthy volunteers. Symptoms were rated by using the Positive and Negative Syndrome Scale. RESULTS: The total and gray matter volume of the right superior temporal gyrus was significantly lower in patients with early-onset schizophrenia than in the healthy volunteers, even after differences in whole brain volume were controlled. Bilateral superior temporal gyrus volumes were positively correlated with the age at onset of psychosis, while severity of thought disorder and hallucinations were inversely related to right superior temporal gyrus volume. CONCLUSIONS: In patients with early-onset schizophrenia, the predominantly right-sided volumetric abnormalities found in the superior temporal gyrus may reflect a particularly early neurodevelopmental disruption. The relationship between language-related symptoms and superior temporal gyrus volume is similar to that seen in adult-onset cases but not as lateralized.

This article has been cited by other articles:

				N. Gogtay Cortical Brain Development in Schizophrenia: Insights From Neuroimaging Studies in Childhood-Onset Schizophrenia Schizophr Bull, January 1, 2008; 34(1): 30 - 36. [Abstract] [Full Text] [PDF]

				R. G. STEEN, C. MULL, R. MCCLURE, R. M. HAMER, and J. A. LIEBERMAN Brain volume in first-episode schizophrenia: Systematic review and meta-analysis of magnetic resonance imaging studies The British Journal of Psychiatry, June 1, 2006; 188(6): 510 - 518. [Abstract] [Full Text] [PDF]

				R. Honea, T. J. Crow, D. Passingham, and C. E. Mackay Regional Deficits in Brain Volume in Schizophrenia: A Meta-Analysis of Voxel-Based Morphometry Studies Am J Psychiatry, December 1, 2005; 162(12): 2233 - 2245. [Abstract] [Full Text] [PDF]

				S. L. COLLINSON, C. E. MACKAY, A. C. JAMES, D. J. QUESTED, T. PHILLIPS, N. ROBERTS, and T. J. CROW Brain volume, asymmetry and intellectual impairment in relation to sex in early-onset schizophrenia The British Journal of Psychiatry, August 1, 2003; 183(2): 114 - 120. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2001 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us