Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Kopala, L. C. Articles by Honer, W. G. Search for Related Content PubMed Citation Articles by Kopala, L. C. Articles by Honer, W. G. Neurophysiology Schizophrenia Spectrum Disorders Genetics Other Research Techniques

Impaired Olfactory Identification in Relatives of Patients With Familial Schizophrenia

OBJECTIVE: Impaired olfactory identification ability has previously been demonstrated in patients with schizophrenia. This study assessed olfactory function in psychotic and nonpsychotic members of multigenerational families with familial schizophrenia to determine whether deficits were present in both groups. METHOD: The University of Pennsylvania Smell Identification Test was administered birhinally to three groups of subjects aged less than 65 years: 19 psychotic and 27 nonpsychotic members of families with familial schizophrenia and 43 age- and sex-matched healthy volunteers. RESULTS: Nonpsychotic family members had significantly higher mean University of Pennsylvania Smell Identification Test scores than psychotic family members but were impaired relative to the healthy volunteer group. These group differences could not be accounted for by age, sex, or smoking habit. Fifty-eight percent of the psychotic and 34% of the nonpsychotic family members performed in the microsmic (impaired) range, compared to 9% of the healthy volunteers. CONCLUSIONS: Impaired olfactory deficits may aggregate in families with schizophrenia and may be indicative of a genetic predisposition to psychosis.

This article has been cited by other articles:

				B.-A. Nguyen-Khoa, E. L. Goehring Jr, R. M. Vendiola, J. C. Pezzullo, and J. K. Jones Epidemiologic Study of Smell Disturbance in 2 Medical Insurance Claims Populations Arch Otolaryngol Head Neck Surg, August 1, 2007; 133(8): 748 - 757. [Abstract] [Full Text] [PDF]

				D. R. Roalf, B. I. Turetsky, K. Owzar, C. C. Balderston, S. C. Johnson, C. M. Brensinger, R. E. Gur, S. J. Siegel, and P. J. Moberg Unirhinal Olfactory Function in Schizophrenia Patients and First-Degree Relatives J Neuropsychiatry Clin Neurosci, August 1, 2006; 18(3): 389 - 396. [Abstract] [Full Text] [PDF]

				P. J. Moberg, S. E. Arnold, D. R. Roalf, C. C. Balderston, J. Abbazia, C. G. Kohler, R. E. Gur, and B. I. Turetsky Apolipoprotein E Genotype and Odor Identification in Schizophrenia J Neuropsychiatry Clin Neurosci, May 1, 2006; 18(2): 231 - 233. [Abstract] [Full Text] [PDF]

				C. I Rupp, W. W. Fleischhacker, G. Kemmler, H. Oberbauer, A. W Scholtz, C. Wanko, and H. Hinterhuber Various Bilateral Olfactory Deficits in Male Patients With Schizophrenia Schizophr Bull, January 1, 2005; 31(1): 155 - 165. [Abstract] [Full Text] [PDF]

				W. J. Brewer, S. J. Wood, P. D. McGorry, S. M. Francey, L. J. Phillips, A. R. Yung, V. Anderson, D. L. Copolov, B. Singh, D. Velakoulis, et al. Impairment of Olfactory Identification Ability in Individuals at Ultra-High Risk for Psychosis Who Later Develop Schizophrenia Am J Psychiatry, October 1, 2003; 160(10): 1790 - 1794. [Abstract] [Full Text] [PDF]

				D. Malaspina and E. Coleman Olfaction and Social Drive in Schizophrenia Arch Gen Psychiatry, June 1, 2003; 60(6): 578 - 584. [Abstract] [Full Text] [PDF]

				F. J. Kier and V. Molinari "Do-It-Yourself" Dementia Testing: Issues Regarding an Alzheimer's Home Screening Test Gerontologist, June 1, 2003; 43(3): 295 - 301. [Abstract] [Full Text] [PDF]

				B. I. Turetsky, P. J. Moberg, S. E. Arnold, R. L. Doty, and R. E. Gur Low Olfactory Bulb Volume in First-Degree Relatives of Patients With Schizophrenia Am J Psychiatry, April 1, 2003; 160(4): 703 - 708. [Abstract] [Full Text] [PDF]

				J. Arehart-Treichel Reduced Smell Activity May Point To Schizophrenia Predisposition Psychiatr News, August 17, 2001; 36(16): 18 - 18. [Full Text]

Get information about faster international access.

Privacy Policy

Copyright © 2001 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us