Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Nurnberger, J. I. Articles by Reich, W. Search for Related Content PubMed Citation Articles by Nurnberger, J. I., Jr. Articles by Reich, W. Depression Alcohol Genetics

Evidence for a Locus on Chromosome 1 That Influences Vulnerability to Alcoholism and Affective Disorder

OBJECTIVE: Depression (major depression or depressive syndrome) is more prevalent in alcoholic than in nonalcoholic subjects in families with multiple members with alcoholism studied as part of the Collaborative Study on the Genetics of Alcoholism (National Institute on Alcohol Abuse and Alcoholism). First-degree relatives of probands with comorbid alcoholism and depression have a higher prevalence of both disorders than relatives of probands with alcoholism alone, and both groups have a higher prevalence than the relatives of comparison subjects selected without regard to psychopathology. Data from the collaborative study were used to test three phenotypes (comorbid alcoholism and depression, alcoholism or depression, and depression) for genetic linkage. METHOD: Genome-wide sibling-pair linkage analyses were performed with the phenotypes comorbid alcoholism and depression, alcoholism or depression, and depression (major depression or depressive syndrome). Analyses were performed in two data sets (initial and replication data sets) from subject groups ascertained with identical criteria, as well as in the combined data set. RESULTS: Peak lod scores on chromosome 1 (near 120 centimorgan) for the alcoholism or depression phenotype were 5.12, 1.52, and 4.66 in the initial, replication, and combined data sets, respectively. The corresponding lod scores on chromosome 2 were 2.79, 0.20, and 3.26; on chromosome 6, they were 3.39, 0.00, and 0.92; and on chromosome 16, they were 3.13, 0.00, and 2.06. Lod scores on chromosome 2 for the comorbid alcoholism and depression phenotype in the three data sets were 0.00, 4.12, and 2.16, respectively. CONCLUSIONS: The results suggest that a gene or genes on chromosome 1 may predispose some individuals to alcoholism and others to depression (which may be alcohol induced). Loci on other chromosomes may also be of interest.

This article has been cited by other articles:

				S. Cohen-Woods, D. Gaysina, N. Craddock, A. Farmer, J. Gray, C. Gunasinghe, F. Hoda, L. Jones, J. Knight, A. Korszun, et al. Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder Hum. Mol. Genet., April 15, 2009; 18(8): 1504 - 1509. [Abstract] [Full Text] [PDF]

				D. M. Fergusson, J. M. Boden, and L. J. Horwood Tests of Causal Links Between Alcohol Abuse or Dependence and Major Depression Arch Gen Psychiatry, March 1, 2009; 66(3): 260 - 266. [Abstract] [Full Text] [PDF]

				A. SZCZEPANKIEWICZ, M. DMITRZAK-WEGLARZ, M. SKIBINSKA, A. SLOPIEN, A. LESZCZYNSKA-RODZIEWICZ, P. CZERSKI, and J. HAUSER STUDY OF DOPAMINE RECEPTORS GENES POLYMORPHISMS IN BIPOLAR PATIENTS WITH COMORBID ALCOHOL ABUSE Alcohol Alcohol., March 1, 2007; 42(2): 70 - 74. [Abstract] [Full Text] [PDF]

				D. Goldman, G. Oroszi, and F. Ducci The Genetics of Addictions: Uncovering the Genes Focus, August 1, 2006; 4(3): 401. [Abstract] [Full Text] [PDF]

				P. McGuffin, J. Knight, G. Breen, S. Brewster, P. R. Boyd, N. Craddock, M. Gill, A. Korszun, W. Maier, L. Middleton, et al. Whole genome linkage scan of recurrent depressive disorder from the depression network study Hum. Mol. Genet., November 15, 2005; 14(22): 3337 - 3345. [Abstract] [Full Text] [PDF]

				D. S. Hasin, R. D. Goodwin, F. S. Stinson, and B. F. Grant Epidemiology of Major Depressive Disorder: Results From the National Epidemiologic Survey on Alcoholism and Related Conditions Arch Gen Psychiatry, October 1, 2005; 62(10): 1097 - 1106. [Abstract] [Full Text] [PDF]

				X. Luo, H. R. Kranzler, L. Zuo, S. Wang, H. P. Blumberg, and J. Gelernter CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study Hum. Mol. Genet., August 15, 2005; 14(16): 2421 - 2434. [Abstract] [Full Text] [PDF]

				A.-M. Bao, A. Hestiantoro, E. J. W. Van Someren, D. F. Swaab, and J.-N. Zhou Colocalization of corticotropin-releasing hormone and oestrogen receptor-{alpha} in the paraventricular nucleus of the hypothalamus in mood disorders Brain, June 1, 2005; 128(6): 1301 - 1313. [Abstract] [Full Text] [PDF]

				J. I. Nurnberger Jr, R. Wiegand, K. Bucholz, S. O'Connor, E. T. Meyer, T. Reich, J. Rice, M. Schuckit, L. King, T. Petti, et al. A Family Study of Alcohol Dependence: Coaggregation of Multiple Disorders in Relatives of Alcohol-Dependent Probands Arch Gen Psychiatry, December 1, 2004; 61(12): 1246 - 1256. [Abstract] [Full Text] [PDF]

				M. W. Nash, P. Huezo-Diaz, R. J. Williamson, A. Sterne, S. Purcell, F. Hoda, S. S. Cherny, G. R. Abecasis, M. Prince, J. A. Gray, et al. Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships Hum. Mol. Genet., October 1, 2004; 13(19): 2173 - 2182. [Abstract] [Full Text] [PDF]

				J. C. Wang, A. L. Hinrichs, H. Stock, J. Budde, R. Allen, S. Bertelsen, J. M. Kwon, W. Wu, D. M. Dick, J. Rice, et al. Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome Hum. Mol. Genet., September 1, 2004; 13(17): 1903 - 1911. [Abstract] [Full Text] [PDF]

				T. Liang, J. Spence, L. Liu, W. N. Strother, H. W. Chang, J. A. Ellison, L. Lumeng, T.-K. Li, T. Foroud, and L. G. Carr alpha -Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats PNAS, April 15, 2003; 100(8): 4690 - 4695. [Abstract] [Full Text] [PDF]

				A. A. Bachmanov, D. R. Reed, X. Li, S. Li, G. K. Beauchamp, and M. G. Tordoff Voluntary Ethanol Consumption by Mice: Genome-Wide Analysis of Quantitative Trait Loci and Their Interactions in a C57BL/6ByJ x 129P3/J F2 Intercross Genome Res., August 1, 2002; 12(8): 1257 - 1268. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2001 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us