Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Martinot, M.-L. P. Articles by Martinot, J.-L. Search for Related Content PubMed Citation Articles by Martinot, M.-L. P. Articles by Martinot, J.-L. Neurotransmitters Symptoms/Dimensions PET

Decreased Presynaptic Dopamine Function in the Left Caudate of Depressed Patients With Affective Flattening and Psychomotor Retardation

OBJECTIVE: The study assessed striatal presynaptic dopamine function in patients with different subtypes of depression. METHOD: Magnetic resonance imaging and positron emission tomography with [¹⁸F]fluorodopa ([¹⁸F]DOPA) were used to compare six depressed patients with marked affective flattening and psychomotor retardation, six depressed patients with marked impulsivity and anxiety, and 10 healthy comparison subjects. Depressed patient groups were matched for severity of depression. RESULTS: [¹⁸F]DOPA uptake K_i values in the left caudate were significantly lower in patients with psychomotor retardation than in patients with high impulsivity and in comparison subjects. CONCLUSIONS: These results suggest that left caudate dopamine function differs between depressed patients with psychomotor retardation and those with impulsivity and provide direct evidence of a link between dopamine hypofunction and psychomotor retardation in depression.

This article has been cited by other articles:

				O. D. HOWES, A. J. MONTGOMERY, M. ASSELIN, R. M. MURRAY, P. M. GRASBY, and P. K. McGUIRE Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis The British Journal of Psychiatry, December 1, 2007; 191(51): s13 - s18. [Abstract] [Full Text] [PDF]

				B. W. Dunlop and C. B. Nemeroff The Role of Dopamine in the Pathophysiology of Depression Arch Gen Psychiatry, March 1, 2007; 64(3): 327 - 337. [Full Text] [PDF]

				B. P. Taylor, G. E. Bruder, J. W. Stewart, P. J. McGrath, J. Halperin, H. Ehrlichman, and F. M. Quitkin Psychomotor Slowing as a Predictor of Fluoxetine Nonresponse in Depressed Outpatients Am J Psychiatry, January 1, 2006; 163(1): 73 - 78. [Abstract] [Full Text] [PDF]

				M. J. Millan, M. Brocco, M. Papp, F. Serres, C. D. La Rochelle, T. Sharp, J.-L. Peglion, and A. Dekeyne S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 936 - 950. [Abstract] [Full Text] [PDF]

				L. K. Tremblay, C. A. Naranjo, L. Cardenas, N. Herrmann, and U. E. Busto Probing Brain Reward System Function in Major Depressive Disorder: Altered Response to Dextroamphetamine Arch Gen Psychiatry, May 1, 2002; 59(5): 409 - 416. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2001 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us