Am J Psychiatry 158:1884-1890, November 2001
© 2001 American Psychiatric Association
Deficient Inhibition as a Marker for Familial ADHD
Jennifer Crosbie, M.A., and
Russell Schachar, M.D., F.R.C.P.C.
OBJECTIVE: The authors investigated whether deficient inhibitory control, as measured by the stop-signal paradigm, delineates a familial subgroup of attention deficit hyperactivity disorder (ADHD). METHOD: Subjects were 54 ADHD children defined as having poor or good inhibition (on the basis of stop-signal paradigm performance) and 26 healthy comparison children. Family history of ADHD and measures of neurobiological and psychosocial risk were compared among the three groups. RESULTS: ADHD was significantly more prevalent in the families of the children with ADHD who exhibited poor inhibition (48.1%) than in the families of those exhibiting good inhibition (18.5%) or in the families of healthy comparison children (7.7%). No differences in neurobiological or psychosocial risk were found for the three groups. CONCLUSIONS: Deficient inhibition delineates a familial subtype of ADHD. Psychosocial and neurobiological factors did not account for inclusion in the good inhibition group and did not act conjointly with inhibition to increase the risk for ADHD in the poor inhibition group. This study demonstrates that cognitive measures such as a laboratory measure of inhibition can serve as phenotype markers for genetic analyses.
This article has been cited by other articles:
|
|
|
|
 
C.-s. R. Li, H. H.-A. Chao, and T.-W. Lee
Neural Correlates of Speeded as Compared with Delayed Responses in a Stop Signal Task: An Indirect Analog of Risk Taking and Association with an Anxiety Trait
Cereb Cortex,
August 4, 2008;
(2008)
bhn132v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Menzies, S. Achard, S. R. Chamberlain, N. Fineberg, C.-H. Chen, N. del Campo, B. J. Sahakian, T. W. Robbins, and E. Bullmore
Neurocognitive endophenotypes of obsessive-compulsive disorder
Brain,
December 1, 2007;
130(12):
3223 - 3236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Aron, S. Durston, D. M. Eagle, G. D. Logan, C. M. Stinear, and V. Stuphorn
Converging Evidence for a Fronto-Basal-Ganglia Network for Inhibitory Control of Action and Cognition
J. Neurosci.,
October 31, 2007;
27(44):
11860 - 11864.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Gualtieri and L. G. Johnson
Efficient Allocation of Attentional Resources in Patients With ADHD: Maturational Changes From Age 10 to 29.
J Atten Disord,
February 1, 2006;
9(3):
534 - 542.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. V. Faraone and J. Biederman
What Is the Prevalence of Adult ADHD? Results of a Population Screen of 966 Adults
J Atten Disord,
November 1, 2005;
9(2):
384 - 391.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. J. Schachar, J. Crosbie, C. L. Barr, T. J. Ornstein, J. Kennedy, M. Malone, W. Roberts, A. Ickowicz, R. Tannock, S. Chen, et al.
Inhibition of Motor Responses in Siblings Concordant and Discordant for Attention Deficit Hyperactivity Disorder
Am J Psychiatry,
June 1, 2005;
162(6):
1076 - 1082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Langley, L. Marshall, M. van den Bree, H. Thomas, M. Owen, M. O'Donovan, and A. Thapar
Association of the Dopamine D4 Receptor Gene 7-Repeat Allele With Neuropsychological Test Performance of Children With ADHD
Am J Psychiatry,
January 1, 2004;
161(1):
133 - 138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. C. Schweinsburg, O. M. Alhassoon, M. J. Taylor, R. Gonzalez, J. S. Videen, G. G. Brown, T. L. Patterson, and I. Grant
Effects of Alcoholism and Gender on Brain Metabolism
Am J Psychiatry,
June 1, 2003;
160(6):
1180 - 1183.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 2001
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
