Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Jacobsen, L. K. Articles by Innis, R. B. Search for Related Content PubMed Citation Articles by Jacobsen, L. K. Articles by Innis, R. B. Neurotransmitters Cocaine

Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients

OBJECTIVE: Recent work has underscored the role of serotonergic neurotransmission in chronic neural adaptations to cocaine dependence. The authors tested for evidence of serotonergic dysfunction during acute abstinence from cocaine, a period of high risk for relapse in cocaine dependence.METHOD: Binding availability of dopamine transporters and serotonin transporters was measured in 15 cocaine-dependent subjects during acute abstinence and in 37 healthy comparison subjects by using [¹²³I]ß-CIT and single photon emission computed tomography.RESULTS: Significant increases in diencephalic and brainstem serotonin transporter binding (16.7% and 31.6%, respectively) were observed in cocaine-dependent subjects. Brainstem serotonin transporter binding was significantly inversely correlated with age across diagnostic groups.CONCLUSIONS: These findings provide further evidence of serotonergic dysfunction during acute abstinence from chronic cocaine use. Age-related decline in brainstem serotonin transporter binding may underlie the poor response to selective serotonin reuptake inhibitor antidepressants seen in some elderly depressed patients.

This article has been cited by other articles:

				Y. Sekine, Y. Ouchi, N. Takei, E. Yoshikawa, K. Nakamura, M. Futatsubashi, H. Okada, Y. Minabe, K. Suzuki, Y. Iwata, et al. Brain Serotonin Transporter Density and Aggression in Abstinent Methamphetamine Abusers Arch Gen Psychiatry, January 1, 2006; 63(1): 90 - 100. [Abstract] [Full Text] [PDF]

				M. J. Kreek, G. Bart, C. Lilly, K. S. Laforge, and D. A. Nielsen Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments Pharmacol. Rev., March 1, 2005; 57(1): 1 - 26. [Abstract] [Full Text] [PDF]

				R. Buchert, R. Thomasius, F. Wilke, K. Petersen, B. Nebeling, J. Obrocki, O. Schulze, U. Schmidt, and M. Clausen A Voxel-Based PET Investigation of the Long-Term Effects of "Ecstasy" Consumption on Brain Serotonin Transporters Am J Psychiatry, July 1, 2004; 161(7): 1181 - 1189. [Abstract] [Full Text] [PDF]

				R. Buchert, R. Thomasius, B. Nebeling, K. Petersen, J. Obrocki, L. Jenicke, F. Wilke, L. Wartberg, P. Zapletalova, and M. Clausen Long-Term Effects of "Ecstasy" Use on Serotonin Transporters of the Brain Investigated by PET J. Nucl. Med., March 1, 2003; 44(3): 375 - 384. [Abstract] [Full Text] [PDF]

				L. R. McMahon, M. Filip, and K. A. Cunningham Differential Regulation of the Mesoaccumbens Circuit by Serotonin 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors J. Neurosci., October 1, 2001; 21(19): 7781 - 7787. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2000 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us