Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by de Haan, L. Articles by Booij, J. Search for Related Content PubMed Citation Articles by de Haan, L. Articles by Booij, J. Neurotransmitters Schizophrenia Spectrum Disorders Antidepressants

Subjective Experience and Striatal Dopamine D₂ Receptor Occupancy in Patients With Schizophrenia Stabilized by Olanzapine or Risperidone

OBJECTIVE: The authors’ goal was to study the relationship between subjective experience during treatment with olanzapine or risperidone and dopamine D₂ receptor occupancy in stabilized patients with schizophrenia.METHOD: Subjective experience, psychopathology, and extrapyramidal symptoms were assessed, and D₂ receptor occupancy was determined with [¹²³I]iodobenzamide single photon emission computed tomography, in 22 patients whose schizophrenia was stabilized by olanzapine or risperidone.RESULTS: Subjective experience, depression, and negative symptoms were related to dopamine D₂ receptor occupancy, but extrapyramidal symptoms were not.CONCLUSIONS: These results provide preliminary evidence that negative subjective experience is related to high D₂ receptor occupancy. Longitudinal study is required because this relationship may have implications for dosing strategies.

This article has been cited by other articles:

				R. Mizrahi, P. Rusjan, O. Agid, A. Graff, D. C. Mamo, R. B. Zipursky, and S. Kapur Adverse Subjective Experience With Antipsychotics and Its Relationship to Striatal and Extrastriatal D2 Receptors: a PET Study in Schizophrenia Am J Psychiatry, April 1, 2007; 164(4): 630 - 637. [Abstract] [Full Text] [PDF]

				C. Mohr, P. S. Sandor, T. Landis, M. Fathi, and P. Brugger Blinking and schizotypal thinking J Psychopharmacol, September 1, 2005; 19(5): 513 - 520. [Abstract] [PDF]

				L. de HAAN, J. LAVALAYE, J. BOOIJ, and D. LINSZEN Comfort, Self-Confidence, Safety, and Dopamine D2 Receptor Occupancy by Antipsychotics Am J Psychiatry, August 1, 2005; 162(8): 1544 - 1545. [Full Text] [PDF]

				L. de Haan, M. van Bruggen, J. Lavalaye, J. Booij, P. M.A.J. Dingemans, and D. Linszen Subjective Experience and D2 Receptor Occupancy in Patients With Recent-Onset Schizophrenia Treated With Low-Dose Olanzapine or Haloperidol: A Randomized, Double-Blind Study Am J Psychiatry, February 1, 2003; 160(2): 303 - 309. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2000 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us