Am J Psychiatry 157:635-637, April 2000
© 2000 American Psychiatric Association
Age-Related Cognitive Deficits Mediated by Changes in the Striatal Dopamine System
Lars Bäckman, Ph.D.,
Nathalie Ginovart, Ph.D.,
Roger A. Dixon, Ph.D.,
Tarja-Brita Robins Wahlin, M.Sc.,
Åke Wahlin, Ph.D.,
Christer Halldin, M.D., Ph.D., and
Lars Farde, M.D., Ph.D.
OBJECTIVE: The study examined the influence of losses in dopaminergic function on age-related cognitive deficits. METHOD: Eleven healthy subjects (21–68 years of age) completed a set of cognitive tasks used to assess perceptual speed and episodic memory. D2 receptor binding was measured in the caudate and the putamen by using positron emission tomography. RESULTS: A gradual age-related deterioration was found for all cognitive tasks and for D2 binding in both striatal structures. Statistical control of D2 binding eliminated the age-related cognitive variation, whereas residual effects of D2 binding were seen after the analysis controlled for age. CONCLUSIONS: D2 receptor binding is a more important factor than chronological age in accounting for variation in cognitive performance across the adult lifespan. Changes in dopaminergic neurotransmission play an important role in aging-related cognitive decline.
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