Am J Psychiatry 157:409-415, March 2000
© 2000 American Psychiatric Association
Children and Adolescents With Velocardiofacial Syndrome: A Volumetric MRI Study
Stephan Eliez, M.D.,
J. Eric Schmitt, B.S.,
Christopher D. White, B.A., and
Allan L. Reiss, M.D.
OBJECTIVE: Velocardiofacial syndrome is a common genetic condition often accompanied by mild cognitive impairment. Children and adolescents with velocardiofacial syndrome also are at greater risk for developing serious neuropsychiatric disorders in adulthood, particularly schizophrenia-like disorders. The purpose of this preliminary study was to 1) elucidate through brain imaging the neurobiological basis of cognitive and neuropsychiatric problems in velocardiofacial syndrome, and 2) consider the association between variations in neuroanatomy in velocardiofacial syndrome subjects and the associated neurobehavioral phenotype. METHOD: Fifteen children and adolescents with velocardiofacial syndrome were matched by age and gender with 15 comparison subjects. High-resolution magnetic resonance imaging scans were analyzed to provide quantitative measures of specified brain tissues and regions. Rater-blind morphometric analyses were conducted to examine tissue volumes of the four lobes and the cerebellum. RESULTS: Total brain volume was approximately 11% smaller in the children with velocardiofacial syndrome. Gray matter volume was reduced to a lesser extent (7.5%) than white matter volume (16.3%). Multivariate analyses of variance indicated a distinct pattern of regional morphological variation among the children with velocardiofacial syndrome. Specifically, frontal lobe tissue tended to be enlarged relative to the overall reduction in brain volume. Normal symmetry of parietal lobe tissue observed in the comparison group was not evident in the velocardiofacial syndrome group. This loss of symmetry was attributable to a significant reduction of gray matter in the left parietal lobe. CONCLUSIONS: Aberrant brain morphology is associated with velocardiofacial syndrome. These changes are potentially related to the language and learning deficits associated with the syndrome and may provide clues about neurodevelopmental pathways associated with schizophrenia.
This article has been cited by other articles:
|
|
|
|
 
C. E. Bearden, T. G.M. van Erp, R. A. Dutton, H. Tran, L. Zimmermann, D. Sun, J. A. Geaga, T. J. Simon, D. C. Glahn, T. D. Cannon, et al.
Mapping Cortical Thickness in Children with 22q11.2 Deletions
Cereb Cortex,
August 1, 2007;
17(8):
1889 - 1898.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Campbell, E. Daly, F. Toal, A. Stevens, R. Azuma, M. Catani, V. Ng, T. van Amelsvoort, X. Chitnis, W. Cutter, et al.
Brain and behaviour in children with 22q11.2 deletion syndrome: a volumetric and voxel-based morphometry MRI study
Brain,
May 1, 2006;
129(5):
1218 - 1228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Harris
22q11 Deletion Syndrome and Forensic Research: Can We Go There?
J Am Acad Psychiatry Law,
March 1, 2005;
33(1):
106 - 111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. van Amelsvoort, E. Daly, J. Henry, D. Robertson, V. Ng, M. Owen, K. C. Murphy, and D. G. M. Murphy
Brain Anatomy in Adults With Velocardiofacial Syndrome With and Without Schizophrenia: Preliminary Results of a Structural Magnetic Resonance Imaging Study
Arch Gen Psychiatry,
November 1, 2004;
61(11):
1085 - 1096.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. R. Kates, C. P. Burnette, B. A. Bessette, B. S. Folley, L. Strunge, E. W. Jabs, and G. D. Pearlson
Frontal and Caudate Alterations in Velocardiofacial Syndrome (Deletion at Chromosome 22q11.2)
J Child Neurol,
May 1, 2004;
19(5):
337 - 342.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. Barnea-Goraly, V. Menon, B. Krasnow, A. Ko, A. Reiss, and S. Eliez
Investigation of White Matter Structure in Velocardiofacial Syndrome: A Diffusion Tensor Imaging Study
Am J Psychiatry,
October 1, 2003;
160(10):
1863 - 1869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. van Amelsvoort, K. C. Murphy, and D. G. M. Murphy
Chromosome 22qII deletion and brain tissue composition
The British Journal of Psychiatry,
December 1, 2001;
179(6):
559 - 559.
[Full Text]
|
|
|
|
|
|
|
S. Eliez and C. M. Blasey
Chromosome 22q11 deletion and brain structure
The British Journal of Psychiatry,
September 1, 2001;
179(3):
270 - 270.
[Full Text]
|
|
|
|
|
|
|
S. Eliez, C. M. Blasey, E. J. Schmitt, C. D. White, D. Hu, and A. L. Reiss
Velocardiofacial Syndrome: Are Structural Changes in the Temporal and Mesial Temporal Regions Related to Schizophrenia?
Am J Psychiatry,
March 1, 2001;
158(3):
447 - 453.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Eliez, S. E. Antonarakis, M. A. Morris, S. P. Dahoun, and A. L. Reiss
Parental Origin of the Deletion 22q11.2 and Brain Development in Velocardiofacial Syndrome: A Preliminary Study
Arch Gen Psychiatry,
January 1, 2001;
58(1):
64 - 68.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
MRI Shows Aberrant Brain Morphology in Velocardiofacial Syndrome
Journal Watch Psychiatry,
April 1, 2000;
2000(401):
6 - 6.
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 2000
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
