Am J Psychiatry 157:1789-1798, November 2000
© 2000 American Psychiatric Association
Cue-Induced Cocaine Craving: Neuroanatomical Specificity for Drug Users and Drug Stimuli
Hugh Garavan, Ph.D.,
John Pankiewicz, M.D.,
Alan Bloom, Ph.D.,
Jung-Ki Cho, M.D.,
Lori Sperry, M.A.,
Thomas J. Ross, Ph.D.,
Betty Jo Salmeron, M.D.,
Robert Risinger, M.D.,
Dan Kelley, B.S., and
Elliot A. Stein, Ph.D.
OBJECTIVE: Cocaine-related cues have been hypothesized to perpetuate drug abuse by inducing a craving response that prompts drug-seeking behavior. However, the mechanisms, underlying neuroanatomy, and specificity of this neuroanatomy are not yet fully understood. METHOD: To address these issues, experienced cocaine users (N=17) and comparison subjects (N=14) underwent functional magnetic resonance imaging while viewing three separate films that portrayed 1 ) individuals smoking crack cocaine, 2) outdoor nature scenes, and 3) explicit sexual content. Candidate craving sites were identified as those that showed significant activation in the cocaine users when viewing the cocaine film. These sites were then required to show significantly greater activation when contrasted with comparison subjects viewing the cocaine film (population specificity) and cocaine users viewing the nature film (content specificity). RESULTS: Brain regions that satisfied these criteria were largely left lateralized and included the frontal lobe (medial and middle frontal gyri, bilateral inferior frontal gyrus), parietal lobe (bilateral inferior parietal lobule), insula, and limbic lobe (anterior and posterior cingulate gyrus). Of the 13 regions identified as putative craving sites, just three (anterior cingulate, right inferior parietal lobule, and the caudate/lateral dorsal nucleus) showed significantly greater activation during the cocaine film than during the sex film in the cocaine users, which suggests that cocaine cues activated similar neuroanatomical substrates as naturally evocative stimuli in the cocaine users. Finally, contrary to the effects of the cocaine film, cocaine users showed a smaller response than the comparison subjects to the sex film. CONCLUSIONS: These data suggest that cocaine craving is not associated with a dedicated and unique neuroanatomical circuitry; instead, unique to the cocaine user is the ability of learned, drug-related cues to produce brain activation comparable to that seen with nondrug evocative stimuli in healthy comparison subjects.
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[Abstract]
[Full Text]
[PDF]
|
|
|
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28(5):
1198 - 1207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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15(2):
88 - 92.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. OLAUSSON, J. D. JENTSCH, D. D. KRUEGER, N. C. TRONSON, A. C. NAIRN, and J. R. TAYLOR
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Ann. N.Y. Acad. Sci.,
December 1, 2007;
1121(1):
610 - 638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. EVERITT, D. M. HUTCHESON, K. D. ERSCHE, Y. PELLOUX, J. W. DALLEY, and T. W. ROBBINS
The Orbital Prefrontal Cortex and Drug Addiction in Laboratory Animals and Humans
Ann. N.Y. Acad. Sci.,
December 1, 2007;
1121(1):
576 - 597.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Contreras, F. Ceric, and F. Torrealba
Inactivation of the Interoceptive Insula Disrupts Drug Craving and Malaise Induced by Lithium
Science,
October 26, 2007;
318(5850):
655 - 658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-S. Park, J.-H. Sohn, J.-A Suk, S.-H. Kim, S. Sohn, and R. Sparacio
Brain substrates of craving to alcohol cues in subjects with alcohol use disorder
Alcohol Alcohol.,
September 1, 2007;
42(5):
417 - 422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Boileau, A. Dagher, M. Leyton, K. Welfeld, L. Booij, M. Diksic, and C. Benkelfat
Conditioned Dopamine Release in Humans: A Positron Emission Tomography [11C]Raclopride Study with Amphetamine
J. Neurosci.,
April 11, 2007;
27(15):
3998 - 4003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. H. Naqvi, D. Rudrauf, H. Damasio, and A. Bechara
Damage to the Insula Disrupts Addiction to Cigarette Smoking
Science,
January 26, 2007;
315(5811):
531 - 534.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Z. Goldstein, N. Alia-Klein, D. Tomasi, L. Zhang, L. A. Cottone, T. Maloney, F. Telang, E. C. Caparelli, L. Chang, T. Ernst, et al.
Is Decreased Prefrontal Cortical Sensitivity to Monetary Reward Associated With Impaired Motivation and Self-Control in Cocaine Addiction?
Am J Psychiatry,
January 1, 2007;
164(1):
43 - 51.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Kalivas and N. D. Volkow
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Focus,
January 1, 2007;
5(2):
208 - 219.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Boileau, A. Dagher, M. Leyton, R. N. Gunn, G. B. Baker, M. Diksic, and C. Benkelfat
Modeling Sensitization to Stimulants in Humans: An [11C]Raclopride/Positron Emission Tomography Study in Healthy Men
Arch Gen Psychiatry,
December 1, 2006;
63(12):
1386 - 1395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Weinstein and W. M. Cox
Cognitive processing of drug-related stimuli: the role of memory and attention
J Psychopharmacol,
November 1, 2006;
20(6):
850 - 859.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. D. Volkow, G.-J. Wang, F. Telang, J. S. Fowler, J. Logan, A.-R. Childress, M. Jayne, Y. Ma, and C. Wong
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction.
J. Neurosci.,
June 14, 2006;
26(24):
6583 - 6588.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. C. Lee, A. L. Milton, and B. J. Everitt
Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation.
J. Neurosci.,
May 31, 2006;
26(22):
5881 - 5887.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Fuchs, R. K. Branham, and R. E. See
Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen.
J. Neurosci.,
March 29, 2006;
26(13):
3584 - 3588.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. M. J. Vanderschuren, P. Di Ciano, and B. J. Everitt
Involvement of the Dorsal Striatum in Cue-Controlled Cocaine Seeking
J. Neurosci.,
September 21, 2005;
25(38):
8665 - 8670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Dom, B. Sabbe, W. Hulstijn, and W. van den Brink
Substance use disorders and the orbitofrontal cortex: Systematic review of behavioural decision-making and neuroimaging studies
The British Journal of Psychiatry,
September 1, 2005;
187(3):
209 - 220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Kalivas and N. D. Volkow
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162(8):
1403 - 1413.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bencherif, A. S. Guarda, C. Colantuoni, H. T. Ravert, R. F. Dannals, and J. J. Frost
Regional {micro}-Opioid Receptor Binding in Insular Cortex Is Decreased in Bulimia Nervosa and Correlates Inversely with Fasting Behavior
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August 1, 2005;
46(8):
1349 - 1351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aron, H. Fisher, D. J. Mashek, G. Strong, H. Li, and L. L. Brown
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J Neurophysiol,
July 1, 2005;
94(1):
327 - 337.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. D. Volkow, G.-J. Wang, Y. Ma, J. S. Fowler, C. Wong, Y.-S. Ding, R. Hitzemann, J. M. Swanson, and P. Kalivas
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J. Neurosci.,
April 13, 2005;
25(15):
3932 - 3939.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-K. Zubieta, M. M. Heitzeg, Y. Xu, R. A. Koeppe, L. Ni, S. Guthrie, and E. F. Domino
Regional Cerebral Blood Flow Responses to Smoking in Tobacco Smokers After Overnight Abstinence
Am J Psychiatry,
March 1, 2005;
162(3):
567 - 577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Hester and H. Garavan
Executive Dysfunction in Cocaine Addiction: Evidence for Discordant Frontal, Cingulate, and Cerebellar Activity
J. Neurosci.,
December 8, 2004;
24(49):
11017 - 11022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Heinz, T. Siessmeier, J. Wrase, D. Hermann, S. Klein, S. M. Grusser-Sinopoli, H. Flor, D. F. Braus, H. G. Buchholz, G. Grunder, et al.
Correlation Between Dopamine D2 Receptors in the Ventral Striatum and Central Processing of Alcohol Cues and Craving
Am J Psychiatry,
October 1, 2004;
161(10):
1783 - 1789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. Thompson, K. M. Hayashi, S. L. Simon, J. A. Geaga, M. S. Hong, Y. Sui, J. Y. Lee, A. W. Toga, W. Ling, and E. D. London
Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine
J. Neurosci.,
June 30, 2004;
24(26):
6028 - 6036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. McFarland, S. B. Davidge, C. C. Lapish, and P. W. Kalivas
Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior
J. Neurosci.,
February 18, 2004;
24(7):
1551 - 1560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Kilts, R. E. Gross, T. D. Ely, and K. P.G. Drexler
The Neural Correlates of Cue-Induced Craving in Cocaine-Dependent Women
Am J Psychiatry,
February 1, 2004;
161(2):
233 - 241.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. London, S. L. Simon, S. M. Berman, M. A. Mandelkern, A. M. Lichtman, J. Bramen, A. K. Shinn, K. Miotto, J. Learn, Y. Dong, et al.
Mood Disturbances and Regional Cerebral Metabolic Abnormalities in Recently Abstinent Methamphetamine Abusers
Arch Gen Psychiatry,
January 1, 2004;
61(1):
73 - 84.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Siebert, H. J. Markowitsch, and P. Bartel
Amygdala, affect and cognition: evidence from 10 patients with Urbach-Wiethe disease
Brain,
December 1, 2003;
126(12):
2627 - 2637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. DACKIS and C. O'BRIEN
Glutamatergic Agents for Cocaine Dependence
Ann. N.Y. Acad. Sci.,
November 1, 2003;
1003(1):
328 - 345.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Carelli, J. G. Williams, and J. A. Hollander
Basolateral Amygdala Neurons Encode Cocaine Self-Administration and Cocaine-Associated Cues
J. Neurosci.,
September 10, 2003;
23(23):
8204 - 8211.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Susan. F. Tapert, E. H. Cheung, G. G. Brown, L. R. Frank, M. P. Paulus, A. D. Schweinsburg, M. J. Meloy, and S. A. Brown
Neural Response to Alcohol Stimuli in Adolescents With Alcohol Use Disorder
Arch Gen Psychiatry,
July 1, 2003;
60(7):
727 - 735.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. SEE, R. A. FUCHS, C. C. LEDFORD, and J. McLAUGHLIN
Drug Addiction, Relapse, and the Amygdala
Ann. N.Y. Acad. Sci.,
April 1, 2003;
985(1):
294 - 307.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A R Lingford-Hughes, S J C Davies, S McIver, T M Williams, M R C Daglish, and D J Nutt
Addiction: Imaging in clinical neuroscience
Br. Med. Bull.,
March 1, 2003;
65(1):
209 - 222.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. Kalivas
Predisposition to Addiction: Pharmacokinetics, Pharmacodynamics, and Brain Circuitry
Am J Psychiatry,
January 1, 2003;
160(1):
1 - 2.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Carelli
The nucleus accumbens and reward: neurophysiological investigations in behaving animals.
Behav Cogn Neurosci Rev,
December 1, 2002;
1(4):
281 - 296.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. L. Brody, M. A. Mandelkern, E. D. London, A. R. Childress, G. S. Lee, R. G. Bota, M. L. Ho, S. Saxena, L. R. Baxter Jr, D. Madsen, et al.
Brain Metabolic Changes During Cigarette Craving
Arch Gen Psychiatry,
December 1, 2002;
59(12):
1162 - 1172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Z. Goldstein and N. D. Volkow
Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
Am J Psychiatry,
October 1, 2002;
159(10):
1642 - 1652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Porrino, D. Lyons, M. D. Miller, H. R. Smith, D. P. Friedman, J. B. Daunais, and M. A. Nader
Metabolic Mapping of the Effects of Cocaine during the Initial Phases of Self-Administration in the Nonhuman Primate
J. Neurosci.,
September 1, 2002;
22(17):
7687 - 7694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Due, S. A. Huettel, W. G. Hall, and D. C. Rubin
Activation in Mesolimbic and Visuospatial Neural Circuits Elicited by Smoking Cues: Evidence From Functional Magnetic Resonance Imaging
Am J Psychiatry,
June 1, 2002;
159(6):
954 - 960.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. WEISS, R. CICCOCIOPPO, L. H. PARSONS, S. KATNER, X. LIU, E. P. ZORRILLA, G. R. VALDEZ, O. BEN-SHAHAR, S. ANGELETTI, and R. R. RICHTER
Compulsive Drug-Seeking Behavior and Relapse: Neuroadaptation, Stress, and Conditioning Factors
Ann. N.Y. Acad. Sci.,
June 1, 2001;
937(1):
1 - 26.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. H. Gawin
The Scientific Exegesis of Desire: Neuroimaging Crack Craving
Arch Gen Psychiatry,
April 1, 2001;
58(4):
342 - 344.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ciccocioppo, P. P. Sanna, and F. Weiss
Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: Reversal by D1 antagonists
PNAS,
February 13, 2001;
98(4):
1976 - 1981.
[Abstract]
[Full Text]
[PDF]
|
|
|
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