Meta-Analysis of Regional Brain Volumes in Schizophrenia

doi:10.1176/appi.ajp.157.1.16



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	Neurophysiology
	Schizophrenia Spectrum Disorders
	MRI

Am J Psychiatry 157:16-25, January 2000
© 2000 American Psychiatric Association

Special Article

Meta-Analysis of Regional Brain Volumes in Schizophrenia

Ian C. Wright, M.R.C.P., M.R.C.Psych., Sophia Rabe-Hesketh, B.Sc., Ph.D., Peter W.R. Woodruff, Ph.D., M.R.C.Psych., Anthony S. David, M.D., F.R.C.Psych., Robin M. Murray, D.Sc., F.R.C.Psych., and Edward T. Bullmore, Ph.D., M.R.C.Psych.

OBJECTIVE: The authors’ goal was to determine whetherpatients with schizophrenia differ from comparison subjectsin regional brain volumes and whether these differences aresimilar in male and female subjects. METHOD: They conducteda systematic search for structural magnetic resonance imaging(MRI) studies of patients with schizophrenia that reported volumemeasurements of selected cortical, subcortical, and ventricularregions in relation to comparison groups. They carried out ameta-analysis of the volumes of these regions in the patientswith schizophrenia and the comparison subjects using a randomeffects model; they also used random effects regression analysisto examine the influence of gender on effect sizes. RESULTS:Fifty-eight studies were identified as suitable for analysis;these studies included 1,588 independent patients with schizophrenia.Assuming a volume of 100% in the comparison group, they foundthat the mean cerebral volume of the subjects with schizophreniawas smaller (98%), but the mean total ventricular volume ofthe subjects with schizophrenia was greater (126%). Relativeto the cerebral volume differences, the regional volumes ofthe subjects with schizophrenia were 94% in the left and rightamygdala, 94% in the left and 95% in the right hippocampus/amygdala,and 93% in the left and 95% in the right parahippocampus. Relativeto the global ventricular system differences, the largest differencesin ventricular subdivisions were in the right and left bodyof the lateral ventricle, where the volumes of schizophrenicsubjects were 116% and 116%, respectively. For most regions,effect size was not significantly related to gender. CONCLUSIONS:Regional structural differences in patients with schizophreniainclude bilaterally reduced volume of medial temporal lobe structures.There is a need for greater integration of results from structuralMRI studies to avoid redundant research activity.

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J. HALL, J. M. HARRIS, R. SPRENGELMEYER, A. SPRENGELMEYER, A. W. YOUNG, I. M. SANTOS, E. C. JOHNSTONE, and S. M. LAWRIE
Social cognition and face processing in schizophrenia
The British Journal of Psychiatry, August 1, 2004; 185(2): 169 - 170.
[Abstract] [Full Text] [PDF]

A. C. James, S. James, D. M. Smith, and A. Javaloyes
Cerebellar, Prefrontal Cortex, and Thalamic Volumes Over Two Time Points in Adolescent-Onset Schizophrenia
Am J Psychiatry, June 1, 2004; 161(6): 1023 - 1029.
[Abstract] [Full Text] [PDF]

A. K. Stark, H. B.M. Uylings, E. Sanz-Arigita, and B. Pakkenberg
Glial Cell Loss in the Anterior Cingulate Cortex, a Subregion of the Prefrontal Cortex, in Subjects With Schizophrenia
Am J Psychiatry, May 1, 2004; 161(5): 882 - 888.
[Abstract] [Full Text] [PDF]

S. Zammit, P. Allebeck, A. S. David, C. Dalman, T. Hemmingsson, I. Lundberg, and G. Lewis
A Longitudinal Study of Premorbid IQ Score and Risk of Developing Schizophrenia, Bipolar Disorder, Severe Depression, and Other Nonaffective Psychoses
Arch Gen Psychiatry, April 1, 2004; 61(4): 354 - 360.
[Abstract] [Full Text] [PDF]

L. J. Siever and K. L. Davis
The Pathophysiology of Schizophrenia Disorders: Perspectives From the Spectrum
Am J Psychiatry, March 1, 2004; 161(3): 398 - 413.
[Abstract] [Full Text] [PDF]

O. van der Stelt, J. Frye, J. A. Lieberman, and A. Belger
Impaired P3 Generation Reflects High-Level and Progressive Neurocognitive Dysfunction in Schizophrenia
Arch Gen Psychiatry, March 1, 2004; 61(3): 237 - 248.
[Abstract] [Full Text] [PDF]

C. Gaser, I. Nenadic, B. R. Buchsbaum, E. A. Hazlett, and M. S. Buchsbaum
Ventricular Enlargement in Schizophrenia Related to Volume Reduction of the Thalamus, Striatum, and Superior Temporal Cortex
Am J Psychiatry, January 1, 2004; 161(1): 154 - 156.
[Abstract] [Full Text] [PDF]

C. Gaser, I. Nenadic, H.-P. Volz, C. Buchel, and H. Sauer
Neuroanatomy of 'Hearing Voices': A Frontotemporal Brain Structural Abnormality Associated with Auditory Hallucinations in Schizophrenia
Cereb Cortex, January 1, 2004; 14(1): 91 - 96.
[Abstract] [Full Text] [PDF]

S. A. Mitelman, L. Shihabuddin, A. M. Brickman, E. A. Hazlett, and M. S. Buchsbaum
MRI Assessment of Gray and White Matter Distribution in Brodmann's Areas of the Cortex in Patients With Schizophrenia With Good and Poor Outcomes
Am J Psychiatry, December 1, 2003; 160(12): 2154 - 2168.
[Abstract] [Full Text] [PDF]

K. L. Narr, T. Sharma, R. P. Woods, P. M. Thompson, E. R. Sowell, D. Rex, S. Kim, D. Asuncion, S. Jang, J. Mazziotta, et al.
Increases in Regional Subarachnoid CSF Without Apparent Cortical Gray Matter Deficits in Schizophrenia: Modulating Effects of Sex and Age
Am J Psychiatry, December 1, 2003; 160(12): 2169 - 2180.
[Abstract] [Full Text] [PDF]

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