The American Journal of Psychiatry
Journal Home Search Current Issue Past Issues Subscribe All APPI Journals Help Contact Us
 
Quicksearch
Advanced Search
Or Search All APPI Journals
This Article
* Full Text
* Full Text (PDF)
* Alert me when this article is cited
* Alert me if a correction is posted
* Citation Map
Services
* Email this article to a Colleague
* Similar articles in this journal
* Similar articles in PubMed
* Alert me to new issues of the journal
* Add to My Articles & Searches
* Download to citation manager
* reprints & permissions
Citing Articles
* Citing Articles via HighWire
* Citing Articles via Google Scholar
Google Scholar
* Articles by Young, L. T.
* Articles by Patelis-Siotis, I.
* Search for Related Content
PubMed
* PubMed Citation
* Articles by Young, L. T.
* Articles by Patelis-Siotis, I.
Related Collections
* Bipolar Disorder
* Antidepressants
* Lithium
Am J Psychiatry 157:124-126, January 2000
© 2000 American Psychiatric Association

Brief Report

Double-Blind Comparison of Addition of a Second Mood Stabilizer Versus an Antidepressant to an Initial Mood Stabilizer for Treatment of Patients With Bipolar Depression

L. Trevor Young, M.D., Ph.D., Russell T. Joffe, M.D., Janine C. Robb, B.Sc.N., Glenda M. MacQueen, M.D., Ph.D., Michael Marriott, Ph.D., and Irene Patelis-Siotis, M.D.

OBJECTIVE: This study’s purpose was to clarify the appropriate treatment of bipolar depression by comparing the addition of an antidepressant versus a second mood stabilizer for inpatients being treated with lithium carbonate or divalproex sodium. METHOD: Twenty-seven patients were randomly assigned to groups that received double-blind treatment with paroxetine or a second mood stabilizer (lithium carbonate or divalproex sodium) for 6 weeks. RESULTS: Both groups showed significant improvement in depressive symptoms during the 6-week trial. There were significantly more noncompleters in the group being treated with the two mood stabilizers than in the group being treated with a mood stabilizer and paroxetine. CONCLUSIONS: Both treatments appeared to be effective; however, the addition of an antidepressant may have greater clinical utility in the treatment of bipolar depression.




This article has been cited by other articles:


Home page
 Am. J. PsychiatryHome page
M. A. Frye, G. Helleman, S. L. McElroy, L. L. Altshuler, D. O. Black, P. E. Keck Jr., W. A. Nolen, R. Kupka, G. S. Leverich, H. Grunze, et al.
Correlates of Treatment-Emergent Mania Associated With Antidepressant Treatment in Bipolar Depression
Am J Psychiatry, February 1, 2009; 166(2): 164 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. F. Goldberg, R. H. Perlis, C. L. Bowden, M. E. Thase, D. J. Miklowitz, L. B. Marangell, J. R. Calabrese, A. A. Nierenberg, and G. S. Sachs
Manic Symptoms During Depressive Episodes in 1,380 Patients With Bipolar Disorder: Findings From the STEP-BD
Am J Psychiatry, February 1, 2009; 166(2): 173 - 181.
[Abstract] [Full Text] [PDF]

Home page
 The Obstetrician and GynaecologistHome page
J. Studd
Postnatal affective disorders. Part 1: an introduction: Maternal depression: risk factors and treatment options during pregnancy
Obstet Gynaecol (Lond), October 1, 2008; 10(4): 276 - 277.
[Full Text] [PDF]

Home page
 J PsychopharmacolHome page
J. Goldberg
On being bipolar without being bipolar
J Psychopharmacol, June 1, 2008; 22(4): 402 - 403.
[PDF]

Home page
 Am. J. PsychiatryHome page
J. F. Goldberg, R. H. Perlis, S. N. Ghaemi, J. R. Calabrese, C. L. Bowden, S. Wisniewski, D. J. Miklowitz, G. S. Sachs, and M. E. Thase
Adjunctive Antidepressant Use and Symptomatic Recovery Among Bipolar Depressed Patients With Concomitant Manic Symptoms: Findings From the STEP-BD
Am J Psychiatry, September 1, 2007; 164(9): 1348 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
R. H. Belmaker
Modafinil Add-On in the Treatment of Bipolar Depression
Am J Psychiatry, August 1, 2007; 164(8): 1143 - 1145.
[Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
M. A. Frye, H. Grunze, T. Suppes, S. L. McElroy, P. E. Keck Jr., J. Walden, G. S. Leverich, L. L. Altshuler, S. Nakelsky, S. Hwang, et al.
A Placebo-Controlled Evaluation of Adjunctive Modafinil in the Treatment of Bipolar Depression
Am J Psychiatry, August 1, 2007; 164(8): 1242 - 1249.
[Abstract] [Full Text] [PDF]

Home page
 APPI Online CMEHome page
References
PsychiatryOnline CME, May 1, 2007; 2007(1): 2 - 2.
[Full Text]

Home page
 NEJMHome page
R.H. Belmaker
Treatment of Bipolar Depression
N. Engl. J. Med., April 26, 2007; 356(17): 1771 - 1773.
[Full Text] [PDF]

Home page
 FocusHome page
G. S. Leverich, L. L. Altshuler, M. A. Frye, T. Suppes, S. L. McElroy, P. E. Keck Jr., R. W. Kupka, K. D. Denicoff, W. A. Nolen, H. Grunze, et al.
Risk of Switch in Mood Polarity to Hypomania or Mania in Patients With Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers
Focus, January 1, 2007; 5(1): 98 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
R. M. Post, L. L. Altshuler, G. S. Leverich, M. A. Frye, W. A. Nolen, R. W. Kupka, T. Suppes, S. McElroy, P. E. Keck, K. D. Denicoff, et al.
Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline
The British Journal of Psychiatry, August 1, 2006; 189(2): 124 - 131.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. A. Nierenberg, M. J. Ostacher, J. R. Calabrese, T. A. Ketter, L. B. Marangell, D. J. Miklowitz, S. Miyahara, M. S. Bauer, M. E. Thase, S. R. Wisniewski, et al.
Treatment-Resistant Bipolar Depression: A STEP-BD Equipoise Randomized Effectiveness Trial of Antidepressant Augmentation With Lamotrigine, Inositol, or Risperidone
Am J Psychiatry, February 1, 2006; 163(2): 210 - 216.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
G. S. Leverich, L. L. Altshuler, M. A. Frye, T. Suppes, S. L. McElroy, P. E. Keck Jr., R. W. Kupka, K. D. Denicoff, W. A. Nolen, H. Grunze, et al.
Risk of Switch in Mood Polarity to Hypomania or Mania in Patients With Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers
Am J Psychiatry, February 1, 2006; 163(2): 232 - 239.
[Abstract] [Full Text] [PDF]

Home page
 Adv. Psychiatr. Treat.Home page
S. Frangou
Advancing the pharmacological treatment of bipolar depression
Advan. Psychiatr. Treat., January 1, 2005; 11(1): 28 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
H. J. Gijsman, J. R. Geddes, J. M. Rendell, W. A. Nolen, and G. M. Goodwin
Antidepressants for Bipolar Depression: A Systematic Review of Randomized, Controlled Trials
Am J Psychiatry, September 1, 2004; 161(9): 1537 - 1547.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. F. Goldberg, K. E. Burdick, and C. J. Endick
Preliminary Randomized, Double-Blind, Placebo-Controlled Trial of Pramipexole Added to Mood Stabilizers for Treatment-Resistant Bipolar Depression
Am J Psychiatry, March 1, 2004; 161(3): 564 - 566.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
L. Altshuler, T. Suppes, D. Black, W. A. Nolen, P. E. Keck Jr., M. A. Frye, S. McElroy, R. Kupka, H. Grunze, J. Walden, et al.
Impact of Antidepressant Discontinuation After Acute Bipolar Depression Remission on Rates of Depressive Relapse at 1-Year Follow-Up
Am J Psychiatry, July 1, 2003; 160(7): 1252 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 FocusHome page
J. W. Jefferson
Bipolar Disorders: A Brief Guide to Diagnosis and Treatment
Focus, January 1, 2003; 1(1): 7 - 14.
[Full Text] [PDF]

Home page
 FocusHome page
Bibliography for Bipolar Disorder
Focus, January 1, 2003; 1(1): 32 - 33.
[Full Text] [PDF]

Home page
 FocusHome page
R. M.A. Hirschfeld, C. L. Bowden, M. J. Gitlin, P. E. Keck, R. H. Perlis, T. Suppes, M. E. Thase, and K. D. Wagner
Practice Guideline for the Treatment of Patients With Bipolar Disorder (Revision)
Focus, January 1, 2003; 1(1): 64 - 110.
[Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. F. GOLDBERG
Spontaneous Depression Versus Biphasic Cycling
Am J Psychiatry, February 1, 2001; 158(2): 325 - 326.
[Full Text]

Home page
 JAMAHome page
G. S. Sachs
A 25-Year-Old Woman With Bipolar Disorder
JAMA, January 24, 2001; 285(4): 454 - 462.
[Full Text] [PDF]


Get information about faster international access.

Privacy Policy

Copyright © 2000 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us

American Psychiatric Publishing, Inc. American Psychiatric Association
1000 Wilson Boulevard, Suite 1825, Arlington, VA 22209-3901 * 800-368-5777 * appi at psych.org