Am J Psychiatry 156:1046-1051, July 1999
© 1999 American Psychiatric Association
Normalization of Information Processing Deficits in Schizophrenia With Clozapine
Veena Kumari, Ph.D.,
William Soni, M.B., B.S., M.Sc., and
Tonmoy Sharma, M.Sc., M.R.C.Psych.
OBJECTIVE: The authors tested the hypothesis that the use of an atypical drug, clozapine, for patients with schizophrenia is related to less impairment in information processing deficits (assessed by prepulse inhibition of the startle response) than is the use of typical antipsychotics. METHOD: Two groups of schizophrenic patients—receiving either clozapine or a range of typical antipsychotics—were tested for prepulse inhibition (a reduction in response to a startling stimulus, if preceded briefly by a weak, nonstartling stimulus; measured at prepulse-to-pulse intervals of 30 msec, 60 msec, and 120 msec) of the acoustic startle response and compared with a group of healthy volunteers. RESULTS: Patients receiving typical antipsychotics showed less prepulse inhibition with 30-msec and 60-msec prepulse trials than did comparison subjects. Clozapine-treated patients showed normal levels of prepulse inhibition. CONCLUSIONS: Clozapine is superior to typical antipsychotics in normalizing prepulse inhibition, presumably because of its pharmacological effects on prefrontal regions of the brain or its effects on a broader range of neuroreceptors.
This article has been cited by other articles:
|
|
|
|
 
P. A. Csomor, B. K. Yee, J. Feldon, A. Theodoridou, E. Studerus, and F. X. Vollenweider
Impaired Prepulse Inhibition and Prepulse-Elicited Reactivity but Intact Reflex Circuit Excitability in Unmedicated Schizophrenia Patients: a Comparison With Healthy Subjects and Medicated Schizophrenia Patients
Schizophr Bull,
January 1, 2009;
35(1):
244 - 255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Greenwood, D. L. Braff, G. A. Light, K. S. Cadenhead, M. E. Calkins, D. J. Dobie, R. Freedman, M. F. Green, R. E. Gur, R. C. Gur, et al.
Initial Heritability Analyses of Endophenotypic Measures for Schizophrenia: The Consortium on the Genetics of Schizophrenia
Arch Gen Psychiatry,
November 1, 2007;
64(11):
1242 - 1250.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. A. Burgess and M. Granato
Sensorimotor Gating in Larval Zebrafish
J. Neurosci.,
May 2, 2007;
27(18):
4984 - 4994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Hong, A. Summerfelt, I. Wonodi, H. Adami, R. W. Buchanan, and G. K. Thaker
Independent Domains of Inhibitory Gating in Schizophrenia and the Effect of Stimulus Interval
Am J Psychiatry,
January 1, 2007;
164(1):
61 - 65.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. I. Turetsky, M. E. Calkins, G. A. Light, A. Olincy, A. D. Radant, and N. R. Swerdlow
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Schizophr Bull,
January 1, 2007;
33(1):
69 - 94.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. Swerdlow, G. A. Light, K. S. Cadenhead, J. Sprock, M. H. Hsieh, and D. L. Braff
Startle Gating Deficits in a Large Cohort of Patients With Schizophrenia: Relationship to Medications, Symptoms, Neurocognition, and Level of Function
Arch Gen Psychiatry,
December 1, 2006;
63(12):
1325 - 1335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Petryshen, A. Kirby, R. P. Hammer Jr., S. Purcell, S. B. O'Leary, J. B. Singer, A. E. Hill, J. H. Nadeau, M. J. Daly, and P. Sklar
Two Quantitative Trait Loci for Prepulse Inhibition of Startle Identified on Mouse Chromosome 16 Using Chromosome Substitution Strains
Genetics,
December 1, 2005;
171(4):
1895 - 1904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J Hagan and D. N C Jones
Predicting Drug Efficacy for Cognitive Deficits in Schizophrenia
Schizophr Bull,
October 1, 2005;
31(4):
830 - 853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. K. Jones, E. L. Eberle, D. B. Shaw, D. L. McKinzie, and H. E. Shannon
Pharmacologic Interactions between the Muscarinic Cholinergic and Dopaminergic Systems in the Modulation of Prepulse Inhibition in Rats
J. Pharmacol. Exp. Ther.,
March 1, 2005;
312(3):
1055 - 1063.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Aasen, L. Kolli, and V. Kumari
Sex effects in prepulse inhibition and facilitation of the acoustic startle response: implications for pharmacological and treatment studies
J Psychopharmacol,
January 1, 2005;
19(1):
39 - 45.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. Oranje, C. C. Gispen-de Wied, H. G. M. Westenberg, C. Kemner, M. N. Verbaten, and R. S. Kahn
Increasing Dopaminergic Activity: Effects of L-Dopa and Bromocriptine on Human Sensory Gating
J Psychopharmacol,
September 1, 2004;
18(3):
388 - 394.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. L. Barrett, R. Bell, D. Watson, and D. J. King
Effects of Amisulpride, Risperidone and Chlorpromazine on Auditory and Visual Latent Inhibition, Prepulse Inhibition, Executive Function and Eye Movements in Healthy Volunteers
J Psychopharmacol,
June 1, 2004;
18(2):
156 - 172.
[Abstract]
[PDF]
|
|
|
|
|
|
|
V. Kumari, E. Zachariah, A. Galea, H. C. Jones, M. Das, R. Mehrotra, D. Taylor, and T. Sharma
Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study
J Psychopharmacol,
January 1, 2003;
17(1):
89 - 95.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Myles-Worsley
P50 Sensory Gating in Multiplex Schizophrenia Families From a Pacific Island Isolate
Am J Psychiatry,
December 1, 2002;
159(12):
2007 - 2012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Perry, D. Feifel, A. Minassian, I. Bhattacharjie, and D. L. Braff
Information Processing Deficits in Acutely Psychotic Schizophrenia Patients Medicated and Unmedicated at the Time of Admission
Am J Psychiatry,
August 1, 2002;
159(8):
1375 - 1381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Graham, R. W. Langley, A. M. B. Verduzco, C. M. Bradshaw, and E. Szabadi
Effects of ketanserin and haloperidol on prepulse inhibition of the acoustic startle (eyeblink) response and the N1/P2 auditory evoked response in man
J Psychopharmacol,
January 1, 2002;
16(1):
15 - 22.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. B. Binder, B. Kinkead, M. J. Owens, and C. B. Nemeroff
Neurotensin and Dopamine Interactions
Pharmacol. Rev.,
December 1, 2001;
53(4):
453 - 486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Graham, R. W. Langley, C. M. Bradshaw, and E. Szabadi
Effects of haloperidol and clozapine on prepulse inhibition of the acoustic startle response and the N1/P2 auditory evoked potential in man
J Psychopharmacol,
July 1, 2001;
15(4):
243 - 250.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. B. Binder, B. Kinkead, M. J. Owens, C. D. Kilts, and C. B. Nemeroff
Enhanced Neurotensin Neurotransmission Is Involved in the Clinically Relevant Behavioral Effects of Antipsychotic Drugs: Evidence from Animal Models of Sensorimotor Gating
J. Neurosci.,
January 15, 2001;
21(2):
601 - 608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Reavill, S. G. Taylor, M. D. Wood, T. Ashmeade, N. E. Austin, K. Y. Avenell, I. Boyfield, C. L. Branch, J. Cilia, M. C. Coldwell, et al.
Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A
J. Pharmacol. Exp. Ther.,
September 1, 2000;
294(3):
1154 - 1165.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
V. Kumari, W. Soni, V. M. Mathew, and T. Sharma
Prepulse Inhibition of the Startle Response in Men With Schizophrenia: Effects of Age of Onset of Illness, Symptoms, and Medication
Arch Gen Psychiatry,
June 1, 2000;
57(6):
609 - 614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. Swerdlow, Z. A. Martinez, F. M. Hanlon, A. Platten, M. Farid, P. Auerbach, D. L. Braff, and M. A. Geyer
Toward Understanding the Biology of a Complex Phenotype: Rat Strain and Substrain Differences in the Sensorimotor Gating-Disruptive Effects of Dopamine Agonists
J. Neurosci.,
June 1, 2000;
20(11):
4325 - 4336.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1999
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
