Am J Psychiatry 156:946-948, June 1999
© 1999 American Psychiatric Association
Double-Blind Controlled Investigation of Transcranial Magnetic Stimulation for the Treatment of Resistant Major Depression
Colleen Loo, F.R.A.N.Z.C.P.,
Philip Mitchell, M.D., F.R.A.N.Z.C.P., F.R.C.Psych.,
Perminder Sachdev, Ph.D., M.D., F.R.A.N.Z.C.P.,
Benjamin McDarmont, B.Sc.(Psych.),
Gordon Parker, Ph.D., M.D., D.Sc., F.R.A.N.Z.C.P., and
Simon Gandevia, Ph.D., D.Sc., F.R.A.C.P.
OBJECTIVE: The efficacy and safety of left prefrontal repetitive transcranial magnetic stimulation (rTMS) for treating resistant major depression were examined in a double-blind, controlled study. METHOD: Eighteen medication-resistant depressed subjects were randomly assigned to 2 weeks of real or sham rTMS, then permitted up to 4 weeks of real rTMS. Effects on mood, neuropsychological function, EEG, and hearing were assessed. RESULTS: The groups receiving real and sham rTMS improved in mood significantly over the 2-week double-blind period, but there was no significant difference between groups. CONCLUSIONS: Repetitive transcranial magnetic stimulation did not provide significantly greater improvement than did sham treatment. A 4-week course of rTMS, as administered in this study, was safe.
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