Am J Psychiatry 156:675-682, May 1999
© 1999 American Psychiatric Association
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Helen S. Mayberg, M.D.,
Mario Liotti, M.D., Ph.D.,
Stephen K. Brannan, M.D.,
Scott McGinnis, B.S.,
Roderick K. Mahurin, Ph.D.,
Paul A. Jerabek, Ph.D.,
J. Arturo Silva, M.D.,
Janet L. Tekell, M.D.,
Charles C. Martin, Ph.D.,
Jack L. Lancaster, Ph.D., and
Peter T. Fox, M.D.
OBJECTIVE: Theories of human behavior from Plato to Freud have repeatedly emphasized links between emotion and reason, a relationship now commonly attributed to pathways connecting phylogenetically "old" and "new" brain regions. Expanding on this theory, this study examined functional interactions between specific limbic and neocortical regions accompanying normal and disease-associated shifts in negative mood state. METHOD: Regions of concordant functional change accompanying provocation of transient sadness in healthy volunteers and resolution of chronic dysphoric symptoms in depressed patients were examined with two positron emission tomography techniques: [15O]water and [18F]fluorodeoxyglucose, respectively. RESULTS: With sadness, increases in limbic-paralimbic blood flow (subgenual cingulate, anterior insula) and decreases in neocortical regions (right dorsolateral prefrontal, inferior parietal) were identified. With recovery from depression, the reverse pattern, involving the same regions, was seen—limbic metabolic decreases and neocortical increases. A significant inverse correlation between subgenual cingulate and right dorsolateral prefrontal activity was also demonstrated in both conditions. CONCLUSIONS: Reciprocal changes involving subgenual cingulate and right prefrontal cortex occur with both transient and chronic changes in negative mood. The presence and maintenance of functional reciprocity between these regions with shifts in mood in either direction suggests that these regional interactions are obligatory and probably mediate the well-recognized relationships between mood and attention seen in both normal and pathological conditions. The bidirectional nature of this limbic-cortical reciprocity provides additional evidence of potential mechanisms mediating cognitive ("top-down"), pharmacological (mixed), and surgical ("bottom-up") treatments of mood disorders such as depression.
This article has been cited by other articles:
|
|
|
|
 
S. J. Tye, M. A. Frye, and K. H. Lee
Disrupting Disordered Neurocircuitry: Treating Refractory Psychiatric Illness With Neuromodulation
Mayo Clin. Proc.,
June 1, 2009;
84(6):
522 - 532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bar
The proactive brain: memory for predictions
Phil Trans R Soc B,
May 12, 2009;
364(1521):
1235 - 1243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. B. Nemeroff, J. D. Bremner, E. B. Foa, H. S. Mayberg, C. S. North, and M. B. Stein
Posttraumatic Stress Disorder: A State-of-the-Science Review
Focus,
April 1, 2009;
7(2):
254 - 273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Binder, R. H. Desai, W. W. Graves, and L. L. Conant
Where Is the Semantic System? A Critical Review and Meta-Analysis of 120 Functional Neuroimaging Studies
Cereb Cortex,
March 27, 2009;
(2009)
bhp055v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Desseilles, E. Balteau, V. Sterpenich, T. T. Dang-Vu, A. Darsaud, G. Vandewalle, G. Albouy, E. Salmon, F. Peters, C. Schmidt, et al.
Abnormal Neural Filtering of Irrelevant Visual Information in Depression
J. Neurosci.,
February 4, 2009;
29(5):
1395 - 1403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Van Oudenhove, J Vandenberghe, B Geeraerts, R Vos, P Persoons, B Fischler, K Demyttenaere, and J Tack
Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation?
Gut,
December 1, 2008;
57(12):
1666 - 1673.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Koenigs, E. D. Huey, M. Calamia, V. Raymont, D. Tranel, and J. Grafman
Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression
J. Neurosci.,
November 19, 2008;
28(47):
12341 - 12348.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. A. Strigo, A. N. Simmons, S. C. Matthews, A. D. Craig, and M. P. Paulus
Association of Major Depressive Disorder With Altered Functional Brain Response During Anticipation and Processing of Heat Pain
Arch Gen Psychiatry,
November 1, 2008;
65(11):
1275 - 1284.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lothe, A. Didelot, A. Hammers, N. Costes, M. Saoud, F. Gilliam, and P. Ryvlin
Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study
Brain,
October 1, 2008;
131(10):
2765 - 2782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Noel, P. Quinette, B. Guillery-Girard, J. Dayan, P. Piolino, S. Marquis, V. de la Sayette, F. Viader, B. Desgranges, and F. Eustache
Psychopathological factors, memory disorders and transient global amnesia
The British Journal of Psychiatry,
August 1, 2008;
193(2):
145 - 151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Neimat, C. Hamani, P. Giacobbe, H. Merskey, S. H. Kennedy, H. S. Mayberg, and A. M. Lozano
Neural Stimulation Successfully Treats Depression in Patients With Prior Ablative Cingulotomy
Am J Psychiatry,
June 1, 2008;
165(6):
687 - 693.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Johansen-Berg, D. A. Gutman, T. E. J. Behrens, P. M. Matthews, M. F. S. Rushworth, E. Katz, A. M. Lozano, and H. S. Mayberg
Anatomical Connectivity of the Subgenual Cingulate Region Targeted with Deep Brain Stimulation for Treatment-Resistant Depression
Cereb Cortex,
June 1, 2008;
18(6):
1374 - 1383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S. Alexopoulos, C. F. Murphy, F. M. Gunning-Dixon, V. Latoussakis, D. Kanellopoulos, S. Klimstra, K. O. Lim, and M. J. Hoptman
Microstructural White Matter Abnormalities and Remission of Geriatric Depression
Am J Psychiatry,
February 1, 2008;
165(2):
238 - 244.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Holmes and D. A. Pizzagalli
Spatiotemporal Dynamics of Error Processing Dysfunctions in Major Depressive Disorder
Arch Gen Psychiatry,
February 1, 2008;
65(2):
179 - 188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kito, K. Fujita, and Y. Koga
Changes in Regional Cerebral Blood Flow After Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex in Treatment-Resistant Depression
J Neuropsychiatry Clin Neurosci,
February 1, 2008;
20(1):
74 - 80.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. B. Nemeroff
Recent Findings in the Pathophysiology of Depression
Focus,
January 1, 2008;
6(1):
3 - 14.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Bibliography for Major Depressive Disorder and Suicide
Focus,
January 1, 2008;
6(1):
58 - 62.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. S. Mayberg, A. M. Lozano, V. Voon, H. E. McNeely, D. Seminowicz, C. Hamani, J. M. Schwalb, and S. H. Kennedy
Deep Brain Stimulation for Treatment-Resistant Depression
Focus,
January 1, 2008;
6(1):
143 - 154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-K. Chen, K. M. Johnston, M. Petrides, and A. Ptito
Neural Substrates of Symptoms of Depression Following Concussion in Male Athletes With Persisting Postconcussion Symptoms
Arch Gen Psychiatry,
January 1, 2008;
65(1):
81 - 89.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Silbersweig, J. F Clarkin, M. Goldstein, O. F. Kernberg, O. Tuescher, K. N. Levy, G. Brendel, H. Pan, M. Beutel, M. T. Pavony, et al.
Failure of Frontolimbic Inhibitory Function in the Context of Negative Emotion in Borderline Personality Disorder
Am J Psychiatry,
December 1, 2007;
164(12):
1832 - 1841.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Hammoud, J. M. Hoffman, and M. G. Pomper
Molecular Neuroimaging: From Conventional to Emerging Techniques
Radiology,
October 1, 2007;
245(1):
21 - 42.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Oatley
On the definition and function of emotions
Social Science Information,
September 1, 2007;
46(3):
415 - 419.
[PDF]
|
|
|
|
|
|
|
Y. Moriguchi, J. Decety, T. Ohnishi, M. Maeda, T. Mori, K. Nemoto, H. Matsuda, and G. Komaki
Empathy and Judging Other's Pain: An fMRI Study of Alexithymia
Cereb Cortex,
September 1, 2007;
17(9):
2223 - 2234.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Airan, L. A. Meltzer, M. Roy, Y. Gong, H. Chen, and K. Deisseroth
High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression
Science,
August 10, 2007;
317(5839):
819 - 823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Liberzon, A. P. King, J. C. Britton, K. L. Phan, J. L. Abelson, and S. F. Taylor
Paralimbic and Medial Prefrontal Cortical Involvement in Neuroendocrine Responses to Traumatic Stimuli
Am J Psychiatry,
August 1, 2007;
164(8):
1250 - 1258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Anand, Y. Li, Y. Wang, K. Gardner, and M. J. Lowe
Reciprocal Effects of Antidepressant Treatment on Activity and Connectivity of the Mood Regulating Circuit: An fMRI Study
J Neuropsychiatry Clin Neurosci,
August 1, 2007;
19(3):
274 - 282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Yulug, M. Bakar, I. Karapolat, O. Guzel, and W. R. Schabitz
Topiramate Improves Glucose Metabolism in Choreatic and Depressive Patient: PET Findings
J Neuropsychiatry Clin Neurosci,
August 1, 2007;
19(3):
346 - 347.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Nutt, K. Demyttenaere, Z. Janka, T. Aarre, M. Bourin, P. L. Canonico, J. L. Carrasco, and S. Stahl
The other face of depression, reduced positive affect: the role of catecholamines in causation and cure
J Psychopharmacol,
July 1, 2007;
21(5):
461 - 471.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Mallet, M. Schupbach, K. N'Diaye, P. Remy, E. Bardinet, V. Czernecki, M.-L. Welter, A. Pelissolo, M. Ruberg, Y. Agid, et al.
Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior
PNAS,
June 19, 2007;
104(25):
10661 - 10666.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Kimberley and S. M Lewis
Understanding Neuroimaging
Physical Therapy,
June 1, 2007;
87(6):
670 - 683.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Kennedy, J. Z. Konarski, Z. V. Segal, M. A. Lau, P. J. Bieling, R. S. McIntyre, and H. S. Mayberg
Differences in Brain Glucose Metabolism Between Responders to CBT and Venlafaxine in a 16-Week Randomized Controlled Trial
Am J Psychiatry,
May 1, 2007;
164(5):
778 - 788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Ma, L. Li, N. Shu, J. Liu, G. Gong, Z. He, Z. Li, L. Tan, W. S. Stone, Z. Zhang, et al.
White Matter Abnormalities in First-Episode, Treatment-Naive Young Adults With Major Depressive Disorder
Am J Psychiatry,
May 1, 2007;
164(5):
823 - 826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Mizrahi, P. Rusjan, O. Agid, A. Graff, D. C. Mamo, R. B. Zipursky, and S. Kapur
Adverse Subjective Experience With Antipsychotics and Its Relationship to Striatal and Extrastriatal D2 Receptors: a PET Study in Schizophrenia
Am J Psychiatry,
April 1, 2007;
164(4):
630 - 637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Benedetti, A. Bernasconi, V. Blasi, M. Cadioli, C. Colombo, A. Falini, C. Lorenzi, D. Radaelli, G. Scotti, and E. Smeraldi
Neural and Genetic Correlates of Antidepressant Response to Sleep Deprivation: A Functional Magnetic Resonance Imaging Study of Moral Valence Decision in Bipolar Depression
Arch Gen Psychiatry,
February 1, 2007;
64(2):
179 - 187.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. N. Baliki, D. R. Chialvo, P. Y. Geha, R. M. Levy, R. N. Harden, T. B. Parrish, and A. V. Apkarian
Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back Pain.
J. Neurosci.,
November 22, 2006;
26(47):
12165 - 12173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Kennedy, R. A. Koeppe, E. A. Young, and J.-K. Zubieta
Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women.
Arch Gen Psychiatry,
November 1, 2006;
63(11):
1199 - 1208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-W. Lee, O. Josephs, R. J. Dolan, and H. D. Critchley
Imitating expressions: emotion-specific neural substrates in facial mimicry
Soc Cogn Affect Neurosci,
September 1, 2006;
1(2):
122 - 135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Hunter, A. F. Leuchter, M. L. Morgan, and I. A. Cook
Changes in Brain Function (Quantitative EEG Cordance) During Placebo Lead-In and Treatment Outcomes in Clinical Trials for Major Depression
Am J Psychiatry,
August 1, 2006;
163(8):
1426 - 1432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Y. Joe, T. Tielmann, J. Bucerius, M. J. Reinhardt, H. Palmedo, W. Maier, H.-J. Biersack, and A. Zobel
Response-Dependent Differences in Regional Cerebral Blood Flow Changes with Citalopram in Treatment of Major Depression
J. Nucl. Med.,
August 1, 2006;
47(8):
1319 - 1325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. T. Gualtieri, L. G. Johnson, and K. B. Benedict
Neurocognition in Depression: Patients on and Off Medication Versus Healthy Comparison Subjects
J Neuropsychiatry Clin Neurosci,
May 1, 2006;
18(2):
217 - 225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. F. Taylor, B. Martis, K. D. Fitzgerald, R. C. Welsh, J. L. Abelson, I. Liberzon, J. A. Himle, and W. J. Gehring
Medial Frontal Cortex Activity and Loss-Related Responses to Errors
J. Neurosci.,
April 12, 2006;
26(15):
4063 - 4070.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dolcos and G. McCarthy
Brain Systems Mediating Cognitive Interference by Emotional Distraction
J. Neurosci.,
February 15, 2006;
26(7):
2072 - 2079.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kruger, M. Alda, L. T. Young, K. Goldapple, S. Parikh, and H. S. Mayberg
Risk and Resilience Markers in Bipolar Disorder: Brain Responses to Emotional Challenge in Bipolar Patients and Their Healthy Siblings
Am J Psychiatry,
February 1, 2006;
163(2):
257 - 264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Rosen, S. C. Allison, G. F. Schauer, M. L. Gorno-Tempini, M. W. Weiner, and B. L. Miller
Neuroanatomical correlates of behavioural disorders in dementia
Brain,
November 1, 2005;
128(11):
2612 - 2625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-I. Ito and A. D. Craig
Vagal-Evoked Activity in the Parafascicular Nucleus of the Primate Thalamus
J Neurophysiol,
October 1, 2005;
94(4):
2976 - 2982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Strakowski, C. M. Adler, S. K. Holland, N. P. Mills, M. P. DelBello, and J. C. Eliassen
Abnormal fMRI Brain Activation in Euthymic Bipolar Disorder Patients During a Counting Stroop Interference Task
Am J Psychiatry,
September 1, 2005;
162(9):
1697 - 1705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Coryell, P. Nopoulos, W. Drevets, T. Wilson, and N. C. Andreasen
Subgenual Prefrontal Cortex Volumes in Major Depressive Disorder and Schizophrenia: Diagnostic Specificity and Prognostic Implications
Am J Psychiatry,
September 1, 2005;
162(9):
1706 - 1712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Bremner, N. Fani, A. Ashraf, J. R. Votaw, M. E. Brummer, T. Cummins, V. Vaccarino, M. M. Goodman, L. Reed, S. Siddiq, et al.
Functional Brain Imaging Alterations in Acne Patients Treated With Isotretinoin
Am J Psychiatry,
May 1, 2005;
162(5):
983 - 991.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V Morgan, D Pickens, S Gautam, R Kessler, and H Mertz
Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome
Gut,
May 1, 2005;
54(5):
601 - 607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Etkin, C. Pittenger, H. J. Polan, and E. R. Kandel
Toward a Neurobiology of Psychotherapy: Basic Science and Clinical Applications
J Neuropsychiatry Clin Neurosci,
May 1, 2005;
17(2):
145 - 158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Nofzinger, D. J. Buysse, A. Germain, J. C. Price, C. C. Meltzer, J. M. Miewald, and D. J. Kupfer
Alterations in Regional Cerebral Glucose Metabolism Across Waking and Non-Rapid Eye Movement Sleep in Depression
Arch Gen Psychiatry,
April 1, 2005;
62(4):
387 - 396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Milak, R. V. Parsey, J. Keilp, M. A. Oquendo, K. M. Malone, and J. J. Mann
Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder
Arch Gen Psychiatry,
April 1, 2005;
62(4):
397 - 408.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Najib, J. P. Lorberbaum, S. Kose, D. E. Bohning, and M. S. George
Regional Brain Activity in Women Grieving a Romantic Relationship Breakup
Am J Psychiatry,
December 1, 2004;
161(12):
2245 - 2256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Kan, M Mimura, K Kamijima, and M Kawamura
Recognition of emotion from moving facial and prosodic stimuli in depressed patients
J. Neurol. Neurosurg. Psychiatry,
December 1, 2004;
75(12):
1667 - 1671.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. E. Ottowitz, D. D. Dougherty, A. Sirota, R. Niaura, S. L. Rauch, and W. A. Brown
Neural and Endocrine Correlates of Sadness In Women: Implications for Neural Network Regulation of HPA Activity
J Neuropsychiatry Clin Neurosci,
November 1, 2004;
16(4):
446 - 455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Weikop, J. Kehr, and J. Scheel-Kruger
The Role of {alpha}1- and {alpha}2-Adrenoreceptors on Venlafaxineinduced Elevation of Extracellular Serotonin, Noradrenaline and Dopamine Levels in the Rat Prefrontal Cortex and Hippocampus
J Psychopharmacol,
September 1, 2004;
18(3):
395 - 403.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. H. Y. Fu, S. C. R. Williams, A. J. Cleare, M. J. Brammer, N. D. Walsh, J. Kim, C. M. Andrew, E. M. Pich, P. M. Williams, L. J. Reed, et al.
Attenuation of the Neural Response to Sad Faces in Major Depression by Antidepressant Treatment: A Prospective, Event-Related Functional Magnetic Resonance Imaging Study
Arch Gen Psychiatry,
September 1, 2004;
61(9):
877 - 889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Chang, N. E. Adleman, K. Dienes, D. I. Simeonova, V. Menon, and A. Reiss
Anomalous Prefrontal-Subcortical Activation in Familial Pediatric Bipolar Disorder: A Functional Magnetic Resonance Imaging Investigation
Arch Gen Psychiatry,
August 1, 2004;
61(8):
781 - 792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Vlassenko, Y. I. Sheline, K. Fischer, and M. A. Mintun
Cerebral Perfusion Response to Successful Treatment of Depression With Different Serotoninergic Agents
J Neuropsychiatry Clin Neurosci,
August 1, 2004;
16(3):
360 - 363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Young, L. A. Holcomb, U. Yazdani, P. B. Hicks, and D. C. German
Elevated Neuron Number in the Limbic Thalamus in Major Depression
Am J Psychiatry,
July 1, 2004;
161(7):
1270 - 1277.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. D. Taylor, J. R. MacFall, M. E. Payne, D. R. McQuoid, J. M. Provenzale, D. C. Steffens, and K. R. R. Krishnan
Late-Life Depression and Microstructural Abnormalities in Dorsolateral Prefrontal Cortex White Matter
Am J Psychiatry,
July 1, 2004;
161(7):
1293 - 1296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Rosa-Neto, M. Diksic, H. Okazawa, M. Leyton, N. Ghadirian, S. Mzengeza, A. Nakai, G. Debonnel, P. Blier, and C. Benkelfat
Measurement of Brain Regional {alpha}-[11C]Methyl-L-Tryptophan Trapping as a Measure of Serotonin Synthesis in Medication-Free Patients With Major Depression
Arch Gen Psychiatry,
June 1, 2004;
61(6):
556 - 563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Mataix-Cols, S. Wooderson, N. Lawrence, M. J. Brammer, A. Speckens, and M. L. Phillips
Distinct Neural Correlates of Washing, Checking, and Hoarding Symptom Dimensions in Obsessive-compulsive Disorder
Arch Gen Psychiatry,
June 1, 2004;
61(6):
564 - 576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Carbon, S. Su, V. Dhawan, D. Raymond, S. Bressman, and D. Eidelberg
Regional metabolism in primary torsion dystonia: Effects of penetrance and genotype
Neurology,
April 27, 2004;
62(8):
1384 - 1390.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Heckers, A. P. Weiss, T. Deckersbach, D. C. Goff, R. J. Morecraft, and G. Bush
Anterior Cingulate Cortex Activation During Cognitive Interference in Schizophrenia
Am J Psychiatry,
April 1, 2004;
161(4):
707 - 715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Richell and M. Anderson
Reproducibility of Negative Mood Induction: a Self-Referent Plus Musical Mood Induction Procedure and a Controllable/Uncontrollable Stress Paradigm
J Psychopharmacol,
March 1, 2004;
18(1):
94 - 101.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. D. Kilts, R. E. Gross, T. D. Ely, and K. P.G. Drexler
The Neural Correlates of Cue-Induced Craving in Cocaine-Dependent Women
Am J Psychiatry,
February 1, 2004;
161(2):
233 - 241.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Jorge, R. G. Robinson, D. Moser, A. Tateno, B. Crespo-Facorro, and S. Arndt
Major Depression Following Traumatic Brain Injury
Arch Gen Psychiatry,
January 1, 2004;
61(1):
42 - 50.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Fossati, S. J. Hevenor, S. J. Graham, C. Grady, M. L. Keightley, F. Craik, and H. Mayberg
In Search of the Emotional Self: An fMRI Study Using Positive and Negative Emotional Words
Am J Psychiatry,
November 1, 2003;
160(11):
1938 - 1945.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Surguladze, P. Keedwell, and M. Phillips
Neural systems underlying affective disorders
Advan. Psychiatr. Treat.,
November 1, 2003;
9(6):
446 - 455.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-K. Zubieta, T. A. Ketter, J. A. Bueller, Y. Xu, M. R. Kilbourn, E. A. Young, and R. A. Koeppe
Regulation of Human Affective Responses by Anterior Cingulate and Limbic {micro}-Opioid Neurotransmission
Arch Gen Psychiatry,
November 1, 2003;
60(11):
1145 - 1153.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Paradiso, N. C. Andreasen, B. Crespo-Facorro, D. S. O'Leary, G. L. Watkins, L. L. Boles Ponto, and R. D. Hichwa
Emotions in Unmedicated Patients With Schizophrenia During Evaluation With Positron Emission Tomography
Am J Psychiatry,
October 1, 2003;
160(10):
1775 - 1783.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Luu and M. I. Posner
Anterior cingulate cortex regulation of sympathetic activity
Brain,
October 1, 2003;
126(10):
2119 - 2120.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Shumake and F. Gonzalez-Lima
Brain Systems Underlying Susceptibility to Helplessness and Depression
Behav Cogn Neurosci Rev,
September 1, 2003;
2(3):
198 - 221.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. E. Beutel, E. Stern, and D. A. Silbersweig
The Emerging Dialogue Between Psychoanalysis and Neuroscience: Neuroimaging Perspectives
J Am Psychoanal Assoc,
September 1, 2003;
51(3):
773 - 801.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. N. Potenza, M. A. Steinberg, P. Skudlarski, R. K. Fulbright, C. M. Lacadie, M. K. Wilber, B. J. Rounsaville, J. C. Gore, and B. E. Wexler
Gambling Urges in Pathological Gambling: A Functional Magnetic Resonance Imaging Study
Arch Gen Psychiatry,
August 1, 2003;
60(8):
828 - 836.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Bremner, M. Vythilingam, C. K. Ng, E. Vermetten, A. Nazeer, D. A. Oren, R. M. Berman, and D. S. Charney
Regional Brain Metabolic Correlates of {alpha}-Methylparatyrosine-Induced Depressive Symptoms: Implications for the Neural Circuitry of Depression
JAMA,
June 18, 2003;
289(23):
3125 - 3134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ernst, A. S. Kimes, E. D. London, J. A. Matochik, D. Eldreth, S. Tata, C. Contoreggi, M. Leff, and K. Bolla
Neural Substrates of Decision Making in Adults With Attention Deficit Hyperactivity Disorder
Am J Psychiatry,
June 1, 2003;
160(6):
1061 - 1070.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. S Mayberg
Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
Br. Med. Bull.,
March 1, 2003;
65(1):
193 - 207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Phillips, L. J. Gregory, S. Cullen, S. Cohen, V. Ng, C. Andrew, V. Giampietro, E. Bullmore, F. Zelaya, E. Amaro, et al.
The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation
Brain,
March 1, 2003;
126(3):
669 - 684.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Paradiso, R. G. Robinson, L. L. Boles Ponto, G. L. Watkins, and R. D. Hichwa
Regional Cerebral Blood Flow Changes During Visually Induced Subjective Sadness in Healthy Elderly Persons
J Neuropsychiatry Clin Neurosci,
February 1, 2003;
15(1):
35 - 44.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Davidson, W. Irwin, M. J. Anderle, and N. H. Kalin
The Neural Substrates of Affective Processing in Depressed Patients Treated With Venlafaxine
Am J Psychiatry,
January 1, 2003;
160(1):
64 - 75.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Kegeles, K. M. Malone, M. Slifstein, S. P. Ellis, E. Xanthopoulos, J. G. Keilp, C. Campbell, M. Oquendo, R. L. Van Heertum, and J. J. Mann
Response of Cortical Metabolic Deficits to Serotonergic Challenge in Familial Mood Disorders
Am J Psychiatry,
January 1, 2003;
160(1):
76 - 82.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Posener, L. Wang, J. L. Price, M. H. Gado, M. A. Province, M. I. Miller, C. M. Babb, and J. G. Csernansky
High-Dimensional Mapping of the Hippocampus in Depression
Am J Psychiatry,
January 1, 2003;
160(1):
83 - 89.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Black, T. Hershey, J. M. Koller, T. O. Videen, M. A. Mintun, J. L. Price, and J. S. Perlmutter
A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist
PNAS,
December 24, 2002;
99(26):
17113 - 17118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Powazki and D. Walsh
Family distress in palliative medicine: A pilot study of the Family APGAR Scale
American Journal of Hospice and Palliative Medicine,
November 1, 2002;
19(6):
392 - 396.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. Saletu, P. Anderer, C. Di Padova, A. Assandri, and G. M. Saletu-Zyhlarz
Electrophysiological neuroimaging of the central effects of S-adenosyl-L-methionine by mapping of electroencephalograms and event-related potentials and low-resolution brain electromagnetic tomography
Am. J. Clinical Nutrition,
November 1, 2002;
76
(5):
1162S - 1171S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. Schatzberg
Brain Imaging in Affective Disorders: More Questions About Causes Versus Effects
Am J Psychiatry,
November 1, 2002;
159(11):
1807 - 1808.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Liotti, H. S. Mayberg, S. McGinnis, S. L. Brannan, and P. Jerabek
Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression
Am J Psychiatry,
November 1, 2002;
159(11):
1830 - 1840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. G. Cameron and S. Minoshima
Regional Brain Activation Due to Pharmacologically Induced Adrenergic Interoceptive Stimulation in Humans
Psychosom Med,
November 1, 2002;
64(6):
851 - 861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. SMITH, A. PLOGHAUS, P. J. COWEN, J. M. McCLEERY, G. M. GOODWIN, S. SMITH, I. TRACEY, and P. M. MATTHEWS
Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression: Functional magnetic resonance imaging study
The British Journal of Psychiatry,
November 1, 2002;
181(5):
411 - 415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Z. Goldstein and N. D. Volkow
Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
Am J Psychiatry,
October 1, 2002;
159(10):
1642 - 1652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. C. Evans, R. B. Banzett, L. Adams, L. McKay, R. S. J. Frackowiak, and D. R. Corfield
BOLD fMRI Identifies Limbic, Paralimbic, and Cerebellar Activation During Air Hunger
J Neurophysiol,
September 1, 2002;
88(3):
1500 - 1511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Lockwood, G. S. Alexopoulos, and W. G. van Gorp
Executive Dysfunction in Geriatric Depression
Am J Psychiatry,
July 1, 2002;
159(7):
1119 - 1126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Elliott, J. S. Rubinsztein, B. J. Sahakian, and R. J. Dolan
The Neural Basis of Mood-Congruent Processing Biases in Depression
Arch Gen Psychiatry,
July 1, 2002;
59(7):
597 - 604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. S. Mayberg, J. A. Silva, S. K. Brannan, J. L. Tekell, R. K. Mahurin, S. McGinnis, and P. A. Jerabek
The Functional Neuroanatomy of the Placebo Effect
Am J Psychiatry,
May 1, 2002;
159(5):
728 - 737.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Mentis, A. R. McIntosh, K. Perrine, V. Dhawan, B. Berlin, A. Feigin, C. Edwards, P. Mattis, and D. Eidelberg
Relationships Among the Metabolic Patterns That Correlate With Mnemonic, Visuospatial, and Mood Symptoms in Parkinson's Disease
Am J Psychiatry,
May 1, 2002;
159(5):
746 - 754.
[Abstract]
[Full Text]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1999
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
