Am J Psychiatry 156:646-649, April 1999
© 1999 American Psychiatric Association
Double-Blind Treatment of Major Depression With Dehydroepiandrosterone
Owen M. Wolkowitz, M.D.,
Victor I. Reus, M.D.,
Audrey Keebler, B.A.,
Nicola Nelson, B.A.,
Mirit Friedland, B.A.,
Louann Brizendine, M.D., and
Eugene Roberts, Ph.D.
OBJECTIVE: This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans. METHOD: Twenty-two patients with major depression, either medication-free or on stabilized antidepressant regimens, received either DHEA (maximum dose=90 mg/day) or placebo for 6 weeks in a double-blind manner and were rated at baseline and at the end of the 6 weeks with the Hamilton Depression Rating Scale. Patients previously stabilized with antidepressants had the study medication added to that regimen; others received DHEA or placebo alone. RESULTS: DHEA was associated with a significantly greater decrease in Hamilton depression scale ratings than was placebo. Five of the 11 patients treated with DHEA, compared with none of the 11 given placebo, showed a 50% decrease or greater in depressive symptoms. CONCLUSIONS: These results suggest that DHEA treatment may have significant antidepressant effects in some patients with major depression. Further, larger-scale trials are warranted.
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