Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Lin, E. H.B. Articles by Walker, E. A. Search for Related Content PubMed Citation Articles by Lin, E. H.B. Articles by Walker, E. A. Primary Care Depression Antidepressants

Can Enhanced Acute-Phase Treatment of Depression Improve Long-Term Outcomes? A Report of Randomized Trials in Primary Care

OBJECTIVE: The authors' goal was to determine whether improved outcomes from enhanced acute-phase (3-month) treatment for depression in primary care persisted. METHOD: They conducted a 19-month follow-up assessment of 156 patients with major depression in the Collaborative Care intervention trials, which had found greater improvements in treatment adherence and depressive symptoms at 4 and 7 months for patients given enhanced acute-phase treatment than for patients given routine treatment in a primary care setting. Sixty-three of the 116 patients who completed the follow-up assessment had received enhanced treatment, and 53 had received routine treatment in primary care. The Inventory for Depressive Symptomatology and the Hopkins Symptom Checklist were used to measure depressive symptoms. Automated pharmacy data and self-reports were used to assess adherence to and adequacy of pharmacotherapy. RESULTS: At 19 months, the patients who had received enhanced acute-phase treatment did not differ from those who had received routine primary care treatment in clinical outcomes or quality of pharmacotherapy. CONCLUSIONS: Even though enhanced acute-phase treatment of depression in primary care resulted in better treatment adherence and better clinical outcomes at 4 and 7 months, these improvements failed to persist over the following year. Continued enhancement of depression treatment may be needed to ensure better long-term results.

This article has been cited by other articles:

				K. S. Jacob Major depression: revisiting the concept and diagnosis Advan. Psychiatr. Treat., July 1, 2009; 15(4): 279 - 285. [Abstract] [Full Text] [PDF]

				G. E. Simon, W. J. Katon, E. H. B. Lin, C. Rutter, W. G. Manning, M. Von Korff, P. Ciechanowski, E. J. Ludman, and B. A. Young Cost-effectiveness of Systematic Depression Treatment Among People With Diabetes Mellitus Arch Gen Psychiatry, January 1, 2007; 64(1): 65 - 72. [Abstract] [Full Text] [PDF]

				S. Gilbody, P. Bower, J. Fletcher, D. Richards, and A. J. Sutton Collaborative Care for Depression: A Cumulative Meta-analysis and Review of Longer-term Outcomes Arch Intern Med, November 27, 2006; 166(21): 2314 - 2321. [Abstract] [Full Text] [PDF]

				G. Simon Collaborative care for depression BMJ, February 4, 2006; 332(7536): 249 - 250. [Full Text] [PDF]

				E. M. Van Weel-Baumgarten Is depression a chronic illness? A response from the perspective of general practice Chronic Illness, June 1, 2005; 1(2): 113 - 115. [PDF]

				J. Gonzalez, J. W. Williams Jr., P. H. Noel, and S. Lee Adherence to Mental Health Treatment in a Primary Care Clinic J Am Board Fam Med, March 1, 2005; 18(2): 87 - 96. [Abstract] [Full Text] [PDF]

				P. P. Roy-Byrne, M. G. Craske, M. B. Stein, G. Sullivan, A. Bystritsky, W. Katon, D. Golinelli, and C. D. Sherbourne A Randomized Effectiveness Trial of Cognitive-Behavioral Therapy and Medication for Primary Care Panic Disorder Arch Gen Psychiatry, March 1, 2005; 62(3): 290 - 298. [Abstract] [Full Text] [PDF]

				K. Rost, J. M. Pyne, L. M. Dickinson, and A. T. LoSasso Cost-Effectiveness of Enhancing Primary Care Depression Management on an Ongoing Basis Ann. Fam. Med, January 1, 2005; 3(1): 7 - 14. [Abstract] [Full Text] [PDF]

				A. J Dietrich, T. E Oxman, J. W Williams Jr, H. C Schulberg, M. L Bruce, P. W Lee, S. Barry, P. J Raue, J. J Lefever, M. Heo, et al. Re-engineering systems for the treatment of depression in primary care: cluster randomised controlled trial BMJ, September 11, 2004; 329(7466): 602. [Abstract] [Full Text] [PDF]

				M. J. Bair, R. L. Robinson, G. J. Eckert, P. E. Stang, T. W. Croghan, and K. Kroenke Impact of Pain on Depression Treatment Response in Primary Care Psychosom Med, January 1, 2004; 66(1): 17 - 22. [Abstract] [Full Text] [PDF]

				E. Badamgarav, S. R. Weingarten, J. M. Henning, K. Knight, V. Hasselblad, A. Gano Jr., and J. J. Ofman Effectiveness of Disease Management Programs in Depression: A Systematic Review Am J Psychiatry, December 1, 2003; 160(12): 2080 - 2090. [Abstract] [Full Text] [PDF]

				S. Gilbody, P. Whitty, J. Grimshaw, and R. Thomas Educational and Organizational Interventions to Improve the Management of Depression in Primary Care: A Systematic Review JAMA, June 18, 2003; 289(23): 3145 - 3151. [Abstract] [Full Text] [PDF]

				S M Gilbody, P M Whitty, J M Grimshaw, and R E Thomas Improving the detection and management of depression in primary care Qual. Saf. Health Care, April 1, 2003; 12(2): 149 - 155. [Abstract] [Full Text] [PDF]

				S. R Weingarten, J. M Henning, E. Badamgarav, K. Knight, V. Hasselblad, A. Gano Jr, and J. J Ofman Interventions used in disease management programmes for patients with chronic illness---which ones work? Meta-analysis of published reports BMJ, October 26, 2002; 325(7370): 925 - 925. [Abstract] [Full Text] [PDF]

				K. Rost, P. Nutting, J. L Smith, C. E Elliott, and M. Dickinson Managing depression as a chronic disease: a randomised trial of ongoing treatment in primary care BMJ, October 26, 2002; 325(7370): 934 - 934. [Abstract] [Full Text] [PDF]

				J. Unutzer, L. Rubenstein, W. J. Katon, L. Tang, N. Duan, I. T. Lagomasino, and K. B. Wells Two-Year Effects of Quality Improvement Programs on Medication Management for Depression Arch Gen Psychiatry, October 1, 2001; 58(10): 935 - 942. [Abstract] [Full Text] [PDF]

				C. D. Sherbourne, K. B. Wells, N. Duan, J. Miranda, J. Unutzer, L. Jaycox, M. Schoenbaum, L. S. Meredith, and L. V. Rubenstein Long-term Effectiveness of Disseminating Quality Improvement for Depression in Primary Care Arch Gen Psychiatry, July 1, 2001; 58(7): 696 - 703. [Abstract] [Full Text] [PDF]

				G. Andrews Should depression be managed as a chronic disease? BMJ, February 17, 2001; 322(7283): 419 - 421. [Full Text]

				I. M. Anderson, D. J. Nutt, and J. F. W. Deakin Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines J Psychopharmacol, January 1, 2000; 14(1): 3 - 20. [Abstract] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 1999 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us