Am J Psychiatry 156:317-320, February 1999
©Copyright 1999 American Psychiatric Association
B Lymphocyte Antigen D8/17 and Repetitive Behaviors in Autism
Eric Hollander, M.D.,
Gina DelGiudice-Asch, M.D.,
Lorraine Simon, M.A.,
James Schmeidler, Ph.D.,
Charles Cartwright, M.D.,
Concetta M. DeCaria, Ph.D.,
Jee Kwon, B.A.,
Charlotte Cunningham-Rundles, M.D., Ph.D.,
Floresta Chapman, R.N., and
John B. Zabriskie, M.D.
OBJECTIVE: Monoclonal antibody D8/17 identifies a B lymphocyte antigen with expanded expression in rheumatic fever, Sydenham's chorea, and subgroups of obsessive-compulsive disorder and Tourette's syndrome with repetitive behaviors. The authors examined the rate of D8/17 expression in children with autism and its correlation with severity of repetitive behaviors. METHOD: Blood samples from 18 patients with autism and 14 comparable medically ill children were evaluated for percentage of D8/17-positive B cells by immunofluorescence and for streptococcal antibodies. Severity of repetitive behaviors was also determined. RESULTS: The frequency of individuals with  11% D8/17-positive cells was significantly higher in the autistic patients (78%) than the comparison subjects (21%), severity of repetitive behaviors significantly correlated with D8/17 expression, and D8/17-positive patients had significantly higher compulsion scores than D8/17-negative patients. CONCLUSIONS: D8/17 expression is high in patients with autism and may serve as a marker for compulsion severity within autism.
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